Effects of ketoralac tromethamine and indomethacin on primary and secondary bone healing

Abstract

Ketoralac tromethamine is a new non-steroidal anti-inflammatory drug that is being used extensively as an analgesic in orthopaedic surgery, particularly for outpatient procedures. However, as with all non-steroidal anti-inflammatory drugs there have been theoretical concerns about the effect of the drug with regard to bone metabolism and healing. In the present study bone healing of femoral osteotomies was evaluated in rats given ketoralac tromethamine in comparison with two other groups of rats given indomethacin and saline (control group), respectively. Under unstable healing conditions, 3 days of medication with indomethacin significantly reduced the femoral bending moment, bending rigidity and energy expenditure compared with the control group. Such impairment of mechanical characteristics was not found during the first 3 days after osteotomy in rats given ketoralac tromethamine. There were no significant differences in mechanical properties between the three groups when healing occurred under stable conditions.