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Published in: Clinical Orthopaedics and Related Research® 4/2008

01-04-2008 | Original Article

Self-assembled Monolayer Films of Phosphonates for Bonding RGD to Titanium

Authors: Andras Heijink, MD, Jeffrey Schwartz, PhD, Mark E. Zobitz, MS, K. Nicole Crowder, MS, Gregory E. Lutz, MD, Jean D. Sibonga, PhD

Published in: Clinical Orthopaedics and Related Research® | Issue 4/2008

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Abstract

Modification of the implant surface with the Arg-Gly-Asp tripeptide (RGD) putatively facilitates osteoblast attachment for improved implant fixation in the laboratory. We compared the histomorphometric and mechanical performance of titanium implants coated with RGD using a novel interface of self-assembled monolayers of phosphonates (RGD/SAMP) and implants coated with RGD using the more conventional thiolate-gold interface (RGD/thiolate-gold). We hypothesized RGD/SAMP-coated implants would show greater bone ongrowth and implant fixation than RGD/thiolate-gold-coated ones. We implanted an RGD/SAMP-coated implant in one femur and an RGD/thiolate-gold-coated in the contralateral femur of 60 rats. At 2, 4, and 8 weeks after implantation, 10 rats were sacrificed for histologic evaluation and another 10 for biomechanical testing. Bone-implant ongrowth and implant force-to-failure of the two implants were similar at all times. Although RGD/SAMP-coated implants did not show superior bone ongrowth and implant fixation, RGD/SAMP-coated implants have at least equally good histomorphometric and mechanical in vivo performance as RGD/thiolate-gold-coated ones. Additional in vivo characterization of self-assembled monolayer films of phosphonates as interface to bond RGD to titanium is needed to explore its full potential and seems justified based on the results of this study.
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Metadata
Title
Self-assembled Monolayer Films of Phosphonates for Bonding RGD to Titanium
Authors
Andras Heijink, MD
Jeffrey Schwartz, PhD
Mark E. Zobitz, MS
K. Nicole Crowder, MS
Gregory E. Lutz, MD
Jean D. Sibonga, PhD
Publication date
01-04-2008
Publisher
Springer-Verlag
Published in
Clinical Orthopaedics and Related Research® / Issue 4/2008
Print ISSN: 0009-921X
Electronic ISSN: 1528-1132
DOI
https://doi.org/10.1007/s11999-008-0117-7

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