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Current Treatment Options in Neurology

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01-11-2018 | Epilepsy (E Waterhouse, Section Editor)

Sleep, Circadian Rhythms, and Epilepsy

Authors: Joseph T. Daley, MD, PhD, Jennifer L. DeWolfe, DO

Published in: Current Treatment Options in Neurology | Issue 11/2018

Abstract

Purpose of review

There is a known interrelationship between sleep and epilepsy. This review highlights the recent findings regarding interactions between sleep and circadian rhythms and the manifestations of epilepsy and surgical treatments for refractory epilepsy.

Recent findings

CLOCK gene expression may be reduced within the epileptogenic focus in patients with refractory epilepsy. Interictal epileptiform discharges during NREM and especially REM sleep may lateralize to the epileptogenic hemisphere. Intracranial video EEG monitoring and EEG from implanted responsive neurostimulator devices confirm scalp video EEG findings of a nocturnal peak for interictal epileptiform discharges. Successful epilepsy surgery may improve sleep macrostructure and quality.

Summary

Sleep outcomes in people with epilepsy undergoing epilepsy surgery and neurostimulator implantation may provide innovative understandings into the associations between sleep and epilepsy. These associations may then provide novel therapeutic options targeting sleep and circadian pathways to improve seizure control and improve the quality of life for patients with this debilitating disorder.

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Title: Sleep, Circadian Rhythms, and Epilepsy
Authors: Joseph T. Daley, MD, PhD
Jennifer L. DeWolfe, DO
Publication date: 01-11-2018
Publisher: Springer US
Published in: Current Treatment Options in Neurology / Issue 11/2018
Print ISSN: 1092-8480
Electronic ISSN: 1534-3138
DOI: https://doi.org/10.1007/s11940-018-0534-1

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Sleep, Circadian Rhythms, and Epilepsy

Abstract

Purpose of review

Recent findings

Summary

Keynote webinar | Spotlight on sleep in brain health

Springer Medicine

Abstract

Purpose of review

Recent findings

Summary

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