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Current Treatment Options in Gastroenterology

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01-06-2021 | Colonoscopy | Colon (JC Anderson, Section Editor)

Serrated Polyposis Syndrome: an Update and Review of the Literature

Authors: Carol Rouphael, MD, Carole Macaron, MD, Carol A. Burke, MD

Published in: Current Treatment Options in Gastroenterology | Issue 2/2021

Abstract

Purpose of review

We present an overview on enhancing the identification of patients with serrated polyps (SPs) and serrated polyposis syndrome (SPS), and provide an update on the prevalence and risk of advanced neoplasia in SPS. We finally share recommendations on the endoscopic management of SPS patients and surveillance of first-degree relatives.

Recent findings

Detection of patients with SPS can be enhanced by recognizing the clinical criteria; tracking cumulative lifetime size, number, and location of SPs; and designing automated processes to track those polyps. The clinical criteria for SPS were revised in 2019 and provide a framework to risk-stratify patients with SPs who are at a substantially high risk of colorectal cancer (CRC) and require aggressive, yet personalized colonoscopy surveillance.

Summary

SPS remains underdiagnosed. Automated systems to identify patients with SPS have been shown to increase SPS detection earlier than a clinician. New data suggest that after clearance, a surveillance interval of 1–3 years appears safe and associated with a low risk of interval CRC.

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Title: Serrated Polyposis Syndrome: an Update and Review of the Literature
Authors: Carol Rouphael, MD
Carole Macaron, MD
Carol A. Burke, MD
Publication date: 01-06-2021
Publisher: Springer US
Keywords: Colonoscopy
Colorectal Cancer
Colorectal Cancer
Published in: Current Treatment Options in Gastroenterology / Issue 2/2021
Print ISSN: 1092-8472
Electronic ISSN: 1534-309X
DOI: https://doi.org/10.1007/s11938-021-00336-z

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