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Current Treatment Options in Gastroenterology

Published in:

01-03-2018 | Inflammatory Bowel Disease (G Lichtenstein, Section Editor)

The Natural History of IBD: Lessons Learned

Authors: Petra Weimers, MD, PhD, Pia Munkholm, MD, DMSci

Published in: Current Treatment Options in Gastroenterology | Issue 1/2018

Abstract

Purpose of Review

Inflammatory bowel diseases (IBD), which include Crohn’s disease (CD) and ulcerative colitis (UC), are chronic, relapsing diseases with unknown etiologies. The purpose of this review is to present the natural disease course evidenced in the latest epidemiology data.

Recent Findings

The prevalence of IBD is rapidly increasing, affecting five million patients worldwide with the highest incidence observed in Northern Europe and Northern America. It has been shown that both CD and UC patients are at an increased risk for developing cancer of the gastrointestinal tract compared to the general population. Though the disease course of IBD is unpredictable, the rate of surgical treatment has declined potentially as a consequence of the introduction of immunomodulators and new biologic treatment options.

Summary

Treatments with biological agents and/or immunosuppressive drugs as well as disease monitoring with eHealth devices seem to have a positive impact on the disease course. However, long-term follow-up studies are still lacking and therefore no reliable conclusions can be drawn as of yet. Medical compliance is paramount in the treatment of IBD, and continuous research focusing on approaches that increase compliance is also necessary.

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Title: The Natural History of IBD: Lessons Learned
Authors: Petra Weimers, MD, PhD
Pia Munkholm, MD, DMSci
Publication date: 01-03-2018
Publisher: Springer US
Published in: Current Treatment Options in Gastroenterology / Issue 1/2018
Print ISSN: 1092-8472
Electronic ISSN: 1534-309X
DOI: https://doi.org/10.1007/s11938-018-0173-3

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Purpose of Review

Recent Findings

Summary

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Updates on Women’s Health Issues in Patients with Inflammatory Bowel Disease

Management of Anemia in Patients with Inflammatory Bowel Disease (IBD)

Update on Bowel Preparation for Colonoscopy

POEM in the Treatment of Esophageal Disorders

Management of Serrated Polyps of the Colon

Biosimilars in the Treatment of Inflammatory Bowel Disease: Supporting Evidence in 2017

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