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01-01-2015 | Kidney Diseases (G Ciancio, Section Editor)

Chronic Kidney Disease and Premature Ageing of the Adaptive Immune Response

Authors: Michiel GH Betjes, Nicolle HR Litjens

Published in: Current Urology Reports | Issue 1/2015

Abstract

Los of renal function is associated with uremia-associated immune deficiency, which contributes significantly to the mortality and morbidity of end-stage renal disease (ESRD) patients. In this review, the effect of ESRD on the adaptive cellular immune system is discussed. Progressive loss of renal function causes a preferential loss of number and function of lymphoid cells. More in depth analysis of these changes reveals a loss of thymic function, attrition of telomeres, and expanded memory T cell population, which is compatible with the concept of premature immunological ageing. Latency for cytomegalovirus is associated with more profound changes and the expansion of a unique pro-inflammatory, cytotoxic subset of CD4-positive CD28null T cells. Epigenetically, modifications in hematopoietic stem cells may underlie uremia-associated immunological ageing, which is not reversed by kidney transplantation. Possible therapeutic options to reverse or halt uremia-associated immunological ageing are discussed.

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Title: Chronic Kidney Disease and Premature Ageing of the Adaptive Immune Response
Authors: Michiel GH Betjes
Nicolle HR Litjens
Publication date: 01-01-2015
Publisher: Springer US
Published in: Current Urology Reports / Issue 1/2015
Print ISSN: 1527-2737
Electronic ISSN: 1534-6285
DOI: https://doi.org/10.1007/s11934-014-0471-9

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Chronic Kidney Disease and Premature Ageing of the Adaptive Immune Response

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