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Current Urology Reports
Published in: Current Urology Reports 1/2015

01-01-2015 | Regenerative Medicine (A Atala, Section Editor)

Production of Urothelium from Pluripotent Stem Cells for Regenerative Applications

Authors: Stephanie L. Osborn, Eric A. Kurzrock

Published in: Current Urology Reports | Issue 1/2015

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Abstract

As bladder reconstruction strategies evolve, a feasible and safe source of transplantable urothelium becomes a major consideration for patients with advanced bladder disease, particularly cancer. Pluripotent stem cells, such as embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), are attractive candidates from which to derive urothelium as they renew and proliferate indefinitely in vitro and fulfill the non-autologous and/or non-urologic criteria, respectively, that is required for many patients. This review presents the latest advancements in differentiating urothelium from pluripotent stem cells in vitro in the context of current bladder tissue engineering strategies.
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Metadata
Title
Production of Urothelium from Pluripotent Stem Cells for Regenerative Applications
Authors
Stephanie L. Osborn
Eric A. Kurzrock
Publication date
01-01-2015
Publisher
Springer US
Published in
Current Urology Reports / Issue 1/2015
Print ISSN: 1527-2737
Electronic ISSN: 1534-6285
DOI
https://doi.org/10.1007/s11934-014-0466-6

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