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Current Rheumatology Reports
Published in: Current Rheumatology Reports 3/2012

01-06-2012 | INFLAMMATORY MUSCLE DISEASE (I LUNDBERG, SECTION EDITOR)

Endoplasmic Reticulum Stress in Skeletal Muscle Homeostasis and Disease

Authors: Sree Rayavarapu, William Coley, Kanneboyina Nagaraju

Published in: Current Rheumatology Reports | Issue 3/2012

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Abstract

Our appreciation of the role of endoplasmic reticulum (ER) stress pathways in both skeletal muscle homeostasis and the progression of muscle diseases is gaining momentum. This review provides insight into ER stress mechanisms during physiologic and pathological disturbances in skeletal muscle. The role of ER stress in the response to dietary alterations and acute stressors, including its role in autoimmune and genetic muscle disorders, has been described. Recent studies identifying ER stress markers in diseased skeletal muscle are noted. The emerging evidence for ER–mitochondrial interplay in skeletal muscle and its importance during chronic ER stress in activation of both inflammatory and cell death pathways (autophagy, necrosis, and apoptosis) have been discussed. Thus, understanding the ER stress–related molecular pathways underlying physiologic and pathological phenotypes in healthy and diseased skeletal muscle should lead to novel therapeutic targets for muscle disease.
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Metadata
Title
Endoplasmic Reticulum Stress in Skeletal Muscle Homeostasis and Disease
Authors
Sree Rayavarapu
William Coley
Kanneboyina Nagaraju
Publication date
01-06-2012
Publisher
Current Science Inc.
Published in
Current Rheumatology Reports / Issue 3/2012
Print ISSN: 1523-3774
Electronic ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-012-0247-5

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