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Current Rheumatology Reports
Published in: Current Rheumatology Reports 6/2010

01-12-2010

Is It All Central Sensitization? Role of Peripheral Tissue Nociception in Chronic Musculoskeletal Pain

Author: Roland Staud

Published in: Current Rheumatology Reports | Issue 6/2010

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Abstract

Fibromyalgia syndrome (FM) is a highly prevalent musculoskeletal disorder that is often accompanied by somatic hyperalgesia (enhanced pain from noxious stimuli). Neural mechanisms of somatic hyperalgesia have been analyzed via quantitative sensory testing of FM patients. Results of these studies suggest that FM pain is associated with widespread primary and secondary cutaneous hyperalgesia, which are dynamically maintained by tonic impulse input from deep tissues and likely by brain-to-spinal cord facilitation. Enhanced somatic pains are accompanied by mechanical hyperalgesia and allodynia in FM patients as compared with healthy controls. FM pain is likely to be at least partially maintained by peripheral impulse input from deep tissues. This conclusion is supported by results of several studies showing that injection of local anesthetics into painful muscles normalizes somatic hyperalgesia in FM patients.
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Metadata
Title
Is It All Central Sensitization? Role of Peripheral Tissue Nociception in Chronic Musculoskeletal Pain
Author
Roland Staud
Publication date
01-12-2010
Publisher
Current Science Inc.
Published in
Current Rheumatology Reports / Issue 6/2010
Print ISSN: 1523-3774
Electronic ISSN: 1534-6307
DOI
https://doi.org/10.1007/s11926-010-0134-x

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