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Current Psychiatry Reports
Published in: Current Psychiatry Reports 8/2015

01-08-2015 | Bipolar Disorders (W Coryell, Section Editor)

Management of Adverse Effects of Mood Stabilizers

Authors: Andrea Murru, Dina Popovic, Isabella Pacchiarotti, Diego Hidalgo, Jordi León-Caballero, Eduard Vieta

Published in: Current Psychiatry Reports | Issue 8/2015

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Abstract

Mood stabilizers such as lithium and anticonvulsants are still standard-of-care for the acute and long-term treatment of bipolar disorder (BD). This systematic review aimed to assess the prevalence of their adverse effects (AEs) and to provide recommendations on their clinical management. We performed a systematic research for studies reporting the prevalence of AEs with lithium, valproate, lamotrigine, and carbamazepine/oxcarbazepine. Management recommendations were then developed. Mood stabilizers have different tolerability profiles and are eventually associated to cognitive, dermatological, endocrine, gastrointestinal, immunological, metabolic, nephrogenic, neurologic, sexual, and teratogenic AEs. Most of those can be transient or dose-related and can be managed by optimizing drug doses to the lowest effective dose. Some rare AEs can be serious and potentially lethal, and require abrupt discontinuation of medication. Integrated medical attention is warranted for complex somatic AEs. Functional remediation and psychoeducation may help to promote awareness on BD and better medication management.
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Metadata
Title
Management of Adverse Effects of Mood Stabilizers
Authors
Andrea Murru
Dina Popovic
Isabella Pacchiarotti
Diego Hidalgo
Jordi León-Caballero
Eduard Vieta
Publication date
01-08-2015
Publisher
Springer US
Published in
Current Psychiatry Reports / Issue 8/2015
Print ISSN: 1523-3812
Electronic ISSN: 1535-1645
DOI
https://doi.org/10.1007/s11920-015-0603-z

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