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01-08-2015 | Bipolar Disorders (W Coryell, Section Editor)

Chronobiology of Bipolar Disorder: Therapeutic Implication

Authors: Sara Dallaspezia, Francesco Benedetti

Published in: Current Psychiatry Reports | Issue 8/2015

Abstract

Multiple lines of evidence suggest that psychopathological symptoms of bipolar disorder arise in part from a malfunction of the circadian system, linking the disease with an abnormal internal timing. Alterations in circadian rhythms and sleep are core elements in the disorders, characterizing both mania and depression and having recently been shown during euthymia. Several human genetic studies have implicated specific genes that make up the genesis of circadian rhythms in the manifestation of mood disorders with polymorphisms in molecular clock genes not only showing an association with the disorder but having also been linked to its phenotypic particularities. Many medications used to treat the disorder, such as antidepressant and mood stabilizers, affect the circadian clock. Finally, circadian rhythms and sleep researches have been the starting point of the developing of chronobiological therapies. These interventions are safe, rapid and effective and they should be considered first-line strategies for bipolar depression.

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Title: Chronobiology of Bipolar Disorder: Therapeutic Implication
Authors: Sara Dallaspezia
Francesco Benedetti
Publication date: 01-08-2015
Publisher: Springer US
Published in: Current Psychiatry Reports / Issue 8/2015
Print ISSN: 1523-3812
Electronic ISSN: 1535-1645
DOI: https://doi.org/10.1007/s11920-015-0606-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Chronobiology of Bipolar Disorder: Therapeutic Implication

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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