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Current Psychiatry Reports
Published in: Current Psychiatry Reports 7/2015

01-07-2015 | Genetic Disorders (W Berrettini, Section Editor)

Pharmacogenetics of Major Depressive Disorder: Top Genes and Pathways Toward Clinical Applications

Authors: Chiara Fabbri, Alessandro Serretti

Published in: Current Psychiatry Reports | Issue 7/2015

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Abstract

The pharmacogenetics of antidepressants has been not only a challenging but also frustrating research field since its birth in the 1990s. Indeed, great expectations followed the first evidence of familiar aggregation of antidepressant response. Despite the progress from candidate gene studies to genome-wide association studies (GWAS), results fell out the expectations and they were often inconsistent. Anyway, the cumulative evidence supports the involvement of some genes and molecular pathways in antidepressant efficacy. The best single genes are SLC6A4, HTR2A, BDNF, GNB3, FKBP5, ABCB1, and cytochrome P450 genes (CYP2D6 and CYP2C19). Molecular pathways involved in inflammation and neuroplasticity show the greatest support. The first studies evaluating benefits of genotype-guided antidepressant treatments provided encouraging results and confirmed the relevance of SLC6A4, HTR2A, ABCB1, and cytochrome P450 genes. Further progress in genotyping and data analysis would allow to move forward and complete the understanding of antidepressant pharmacogenetics and its translation into clinical applications.
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Metadata
Title
Pharmacogenetics of Major Depressive Disorder: Top Genes and Pathways Toward Clinical Applications
Authors
Chiara Fabbri
Alessandro Serretti
Publication date
01-07-2015
Publisher
Springer US
Published in
Current Psychiatry Reports / Issue 7/2015
Print ISSN: 1523-3812
Electronic ISSN: 1535-1645
DOI
https://doi.org/10.1007/s11920-015-0594-9

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