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01-02-2022 | Migraine | Childhood and Adolescent Headache (SE Evers, Section Editor)

The Enigma of New Daily Persistent Headache: What Solutions for Pediatric Age?

Authors: Laura Papetti, Giorgia Sforza, Ilaria Frattale, Samuela Tarantino, Fabiana Ursitti, Michela Ada Noris Ferilli, Federico Vigevano, Massimiliano Valeriani

Published in: Current Pain and Headache Reports | Issue 2/2022

Abstract

Purpose of review

To analyze systematically the evidence currently available from the literature regarding the diagnosis, clinical characteristics, treatment and outcome of new daily persistent headache (NDPH).

Recent findings

NDPH is a primary headache characterized by an abrupt onset with continuous daily pain that can persist for many months. Although self-limiting forms have been described, NDPH is frequently associated with high disability even in children and adolescents. For this reason, it is very important to recognize it from a diagnostic point of view and to treat it.

Summary

We found little specific data on NDPH in developmental age. Most of the therapy studies have been conducted on adults with conflicting data. Currently, pediatric NDPH therapy is based on experiences in adult patients and in individuals with other forms of primary chronic headache, hence the need for more pediatric studies to fill this information gap.

• Yamani N, Olesen J. New daily persistent headache: a systematic review on an enigmatic disorder. Headache Pain 2019;20:80. https://doi.org/10.1186/s10194-019-1022-z. This updated and comprehensive review on the characteristics of NDPH in the general population.

•• Papetti L, Sforza G, Tarantino S, Moavero R, Ruscitto C, Ursitti F, Ferilli MAN, Vigevano F, Valeriani M. Features and management of new daily persistent headache in developmental-age patients. Diagnostics (Basel) 2021;11:385. https://doi.org/10.3390/diagnostics11030385. This study illustrates important and useful suggestions on the diagnostic and therapeutic management of NDPH in developmental age.

Gladstein J, Rothner AD. Chronic daily headache in children and adolescents. Semin Pediatr Neurol. 2010;17:88–92.CrossRef

• Robbins MS, Grosberg BM, Napchan U, Crystal SC, Lipton RB. Clinical and prognostic subforms of new daily persistent headache. Neurology 2010;74:1358–64. This study emphasizes the different possible long-term evolutions of NDPH.

Vanast WJ. New daily persistent headaches: Definition of a benign syndrome. Headache. 1986;26:317.

Meineri P, Torre E, Rota E, Grasso E. New daily persistent headache: clinical and serological characteristics in a retrospective study. Neurol Sci. 2004;25:S281–2. https://doi.org/10.1007/s10072-004-0310-8.CrossRefPubMed

•• Grengs LR, Mack KJ. New daily persistent headache is most likely to begin at the start of school. J Child Neurol 2016;31:864–868. https://doi.org/10.1177/0883073815624761. This study offers an important contribution in clarifying how school stress can have a significant impact on the progression of headaches in children.

Puledda F, Goadsby PJ, Prabhakar P. Treatment of disabling headache with greater occipital nerve injections in a large population of childhood and adolescent patients: a service evaluation. J Headache Pain. 2018;19:5. https://doi.org/10.1186/s10194-018-0835-5.CrossRefPubMedPubMedCentral

Gelfand AA, Reider AC, Goadsby PJ. Outcomes of greater occipital nerve injections in pediatric patients with chronic primary headache disorders. Pediatr Neurol. 2014;50:135–9.CrossRef

10.

Scalas C, Calistri L. Chronic daily headache in a paediatric headache centre. J Headache Pain. 2005;6:274–6. https://doi.org/10.1007/s10194-005-0209-7.CrossRefPubMedPubMedCentral

11.

Mack KJ. New daily persistent headache in children and adults. Curr Pain Headache Rep. 2009;13:47–51. https://doi.org/10.1007/s11916-009-0010-4.CrossRefPubMed

12.

Gladstein J, Holden EW. Chronic daily headache in children and adolescents: a 2-year prospective study. Headache. 1996;36:349–51. https://doi.org/10.1046/j.1526-4610.1996.3606349.x.CrossRefPubMed

13.

Silberstein SD, Lipton RB, Sliwinski M. Classification of daily and near-daily headaches: field trial of revised IHS criteria. Neurology. 1996;47:871–5. https://doi.org/10.1212/wnl.47.4.871.CrossRefPubMed

14.

Headache Classification Committee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd edition. Cephalalgia. 2018;38:1–211. https://doi.org/10.1177/0333102417738202.

15.

Evans RW, Seifert TD. The challenge of new daily persistent headache. Headache. 2011;51:145–54. https://doi.org/10.1111/j.1526-4610.2010.01812.x.CrossRefPubMed

16.

Lobo R, Wang M, Lobo S, Bahra A. Time to retire “New daily persistent headache”: Mode of onset of chronic migraine and tension-type headache. Cephalalgia. 2021;27:3331024211044440. https://doi.org/10.1177/03331024211044440.CrossRef

17.

Baron EP, Rothner AD. New daily persistent headache in children and adolescents. Curr Neurol Neurosci Rep. 2010;10:127–32. https://doi.org/10.1007/s11910-010-0097-3.CrossRefPubMed

18.

Santoni JR, Santoni-Williams CJ. Headache and painful lymphadenopathy in extracranial or systemic infection: etiology of new daily persistent headaches. Intern Med. 1993;32:530–2. https://doi.org/10.2169/internalmedicine.32.530.CrossRefPubMed

19.

Rozen T, Swidan SZ. Elevation of CSF tumor necrosis factor alpha levels in new daily persistent headache and treatment refractory chronic migraine. Headache. 2007;47:1050–5. https://doi.org/10.1111/j.1526-4610.2006.00722.x.CrossRefPubMed

20.

Prakash S, Saini S, Rana KR, Mahato P. Refining clinical features and therapeutic options of new daily persistent headache: a retrospective study of 63 patients in India. J Headache Pain. 2012;13:477–85. https://doi.org/10.1007/s10194-012-0461-6.CrossRefPubMedPubMedCentral

21.

Fujita M, Fujiwara J, Maki T, Shibasaki K, Shigeta M, Nii J. Pediatric chronic daily headache associated with school phobia. Pediatr Int. 2009;51:621–5. https://doi.org/10.1111/j.1442-200X.2009.02804.x.CrossRefPubMed

22.

Papetti L, Salfa I, Battan B, Moavero R, Termine C, Bartoli B, Di Nunzio F, Tarantino S, Alaimo Di Loro P, Vigevano F, Valeriani M. Features of primary chronic headache in children and adolescents and validity of ICHD 3 Criteria. Front Neurol. 2019;10:92. https://doi.org/10.3389/fneur.2019.00092.

23.

Szperka CL, Gelfand AA, Hershey AD. Patterns of use of peripheral nerve blocks and trigger point injections for pediatric headache: results of a survey of the american headache society pediatric and adolescent section. Headache. 2016;56:1597–607. https://doi.org/10.1111/head.12939.CrossRefPubMedPubMedCentral

24.

Joshi SG, Mathew PG, Markley HG. New daily persistent headache and potential new therapeutic agents. Curr Neurol Neurosci Rep. 2014;14:425. https://doi.org/10.1007/s11910-013-0425-5.CrossRefPubMed

25.

Connelly M, Sekhon S. Current perspectives on the development and treatment of chronic daily headache in children and adolescents. Pain Manag. 2019;9:175–89. https://doi.org/10.2217/pmt-2018-0057.CrossRefPubMed

26.

Spears RC. Efficacy of botulinum toxin type A in new daily persistent headache. J Headache Pain. 2008;9:405–6. https://doi.org/10.1007/s10194-008-0078-y.CrossRefPubMedPubMedCentral

27.

Prakash S, Shah ND. Post-infectious new daily persistent headache may respond to intravenous methylprednisolone. J Headache Pain. 2010;11:59–66. https://doi.org/10.1007/s10194-009-0171-x.CrossRefPubMed

28.

Marmura MJ, Passero FC Jr, Young WB. Mexiletine for refractory chronic daily headache: a report of nine cases. Headache. 2008;48:1506–10. https://doi.org/10.1111/j.1526-4610.2008.01234.x.CrossRefPubMed

29.

Nagy AJ, Gandhi S, Bhola R, Goadsby PJ. Intravenous dihydroergotamine for inpatient management of refractory primary headaches. Neurology. 2011;77(1827–1832):36. https://doi.org/10.1212/WNL.0b013e3182377dbb.CrossRef

30.

Pomeroy JL, Marmura MJ, Nahas SJ, Viscusi ER. Ketamine infusions for treatment refractory headache. Headache. 2017;57:276–82. https://doi.org/10.1111/head.13013.CrossRefPubMed

31.

Rozen TD, Beams JL. New daily persistent headache with a thunderclap headache onset and complete response to Nimodipine (a new distinct subtype of NDPH). J Headache Pain. 2013;14:100. https://doi.org/10.1111/head.13013.CrossRefPubMedPubMedCentral

32.

Akbar A. Response of refractory new daily persistent headache to intravenous lidocaine treatment in a pediatric patient. J Pain Relief. 2017;6:4. https://doi.org/10.4172/2167-0846.1000297.CrossRef

33.

Alexander J. Resolution of new daily persistent headache after osteopathic manipulative treatment. J Am Osteopath Assoc. 2016;116:182–5. https://doi.org/10.7556/jaoa.2016.035.CrossRefPubMed

34.

Rozen TD. New daily-persistent headache. Curr Pain Headache Rep. 2003;7:218. https://doi.org/10.1007/s11916-003-0076-3.CrossRefPubMed

35.

Wintrich S, Rothner D. New daily persistent headaches–follow up and outcome in children and adolescents. Headache. 2010;50:23.

36.

Rozen TD. Triggering events and new daily persistent headache: age and gender differences and insights on pathogenesis-a clinic-based study. Headache. 2016;56:164–73. https://doi.org/10.1111/head.12707.CrossRefPubMed

37.

Takase Y, Nakano M, Tatsumi C, Matsuyama T. Clinical features, effectiveness of drug-based treatment, and prognosis of new daily persistent headache (NDPH): 30 cases in Japan. Cephalalgia. 2004;24:955–9. https://doi.org/10.1111/j.1468-2982.2004.00771.x.CrossRefPubMed

38.

Li D, Rozen TD. The clinical characteristics of new daily persistent headache. Cephalalgia. 2002;22:66–9. https://doi.org/10.1046/j.1468-2982.2002.00326.x.CrossRefPubMed

39.

Evans R. New daily persistent headache. Headache. 2012;52:40–4. https://doi.org/10.1111/j.1526-4610.2012.02135.x.CrossRefPubMed

Title: The Enigma of New Daily Persistent Headache: What Solutions for Pediatric Age?
Authors: Laura Papetti
Giorgia Sforza
Ilaria Frattale
Samuela Tarantino
Fabiana Ursitti
Michela Ada Noris Ferilli
Federico Vigevano
Massimiliano Valeriani
Publication date: 01-02-2022
Publisher: Springer US
Keywords: Migraine
Headache
Published in: Current Pain and Headache Reports / Issue 2/2022
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI: https://doi.org/10.1007/s11916-022-01011-3

At a glance: The STEP trials

Springer Medicine

The Enigma of New Daily Persistent Headache: What Solutions for Pediatric Age?

Abstract

Purpose of review

Recent findings

Summary

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose of review

Recent findings

Summary

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