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01-02-2022 | Neuropathic Pain | Regenerative Pain Medicine/Interventional Pain Medicine (EC Bradley, Section Editors)

Dorsal Column Stimulation and Cannabinoids in the Treatment of Chronic Nociceptive and Neuropathic Pain: a Review of the Clinical and Pre-clinical Data

Authors: Charles A. Odonkor, Tariq AlFarra, Peju Adekoya, Vwaire Orhurhu, Tomás Rodríguez, Emily Sottosanti, Alan D. Kaye

Published in: Current Pain and Headache Reports | Issue 2/2022

Abstract

Purpose of Review

The main objective of this review is to appraise the literature on the role of spinal cord stimulation (SCS), cannabinoid therapy, as well as SCS and cannabinoid combination therapy for the management of chronic neuropathic and nociceptive pain. Current research suggests that SCS reduces pain and increases functional status in carefully selected patients with minimal side effects.

Recent Findings

As cannabinoid-based medications become a topic of increasing interest in pain management, data remains limited regarding the clinical efficacy of cannabinoids for pain relief. Furthermore, from a mechanistic perspective, although various pain treatment modalities utilize overlapping pain-signaling pathways, clarifying whether cannabinoids work synergistically with SCS via shared mechanisms remains to be determined. In considering secondary outcomes, the current literature suggests cannabinoids improve quality of life, specifically sleep quality, and that SCS decreases opioid consumption, increases functional capacity, and decreases long-term healthcare costs.

Summary

These findings, along with the high safety profiles of SCS and cannabinoids overall, incentivize further exploration of cannabinoids as an adjunctive therapy to SCS in the treatment of neuropathic and nociceptive pain.

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Title: Dorsal Column Stimulation and Cannabinoids in the Treatment of Chronic Nociceptive and Neuropathic Pain: a Review of the Clinical and Pre-clinical Data
Authors: Charles A. Odonkor
Tariq AlFarra
Peju Adekoya
Vwaire Orhurhu
Tomás Rodríguez
Emily Sottosanti
Alan D. Kaye
Publication date: 01-02-2022
Publisher: Springer US
Keywords: Neuropathic Pain
Opioids
Opioids
Cannabinoid
Leg Pain
Spinal Cord Stimulation
Leg Pain
Published in: Current Pain and Headache Reports / Issue 2/2022
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI: https://doi.org/10.1007/s11916-022-01008-y

At a glance: The STEP trials

Springer Medicine

Dorsal Column Stimulation and Cannabinoids in the Treatment of Chronic Nociceptive and Neuropathic Pain: a Review of the Clinical and Pre-clinical Data

Abstract

Purpose of Review

Recent Findings

Summary

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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