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Current Pain and Headache Reports
Published in: Current Pain and Headache Reports 5/2019

01-05-2019 | Migraine | Other Pain (A Kaye and N Vadivelu, Section Editors)

CGRP Antagonists for the Treatment of Chronic Migraines: a Comprehensive Review

Authors: Ivan Urits, Mark R. Jones, Kyle Gress, Karina Charipova, Jacob Fiocchi, Alan D. Kaye, Omar Viswanath

Published in: Current Pain and Headache Reports | Issue 5/2019

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Abstract

Purpose of Review

The purpose of the following review is to summarize the most recent understanding of migraine pathophysiology, as well as of basic and clinical science pharmacologic literature regarding the development of calcitonin gene receptor peptide (CGRP) antagonists as a novel therapeutic modality for the treatment of migraine headaches. A review is provided of erenumab, the first of its class FDA approved CGRP antagonist.

Recent Findings

Despite its high prevalence, the occurrence and treatment of migraine headaches is poorly understood. Erenumab and CGRP antagonists as a whole significantly reduce the average number of migraine days experienced in migraine sufferers.

Summary

CGRP antagonists appear to significantly improve treatment outcomes in patients who suffer from episodic and chronic migraines. Erenumab is the first CGRP antagonist to be FDA approved for public use; however, further development of biologics in this class is underway.
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Metadata
Title
CGRP Antagonists for the Treatment of Chronic Migraines: a Comprehensive Review
Authors
Ivan Urits
Mark R. Jones
Kyle Gress
Karina Charipova
Jacob Fiocchi
Alan D. Kaye
Omar Viswanath
Publication date
01-05-2019
Publisher
Springer US
Published in
Current Pain and Headache Reports / Issue 5/2019
Print ISSN: 1531-3433
Electronic ISSN: 1534-3081
DOI
https://doi.org/10.1007/s11916-019-0768-y

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