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Current Osteoporosis Reports

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01-10-2018 | Cancer-induced Musculoskeletal Diseases (J Sterling and E Keller, Section Editors)

Interactions Between Disseminated Tumor Cells and Bone Marrow Stromal Cells Regulate Tumor Dormancy

Authors: D. Brooke Widner, Sun H. Park, Matthew R. Eber, Yusuke Shiozawa

Published in: Current Osteoporosis Reports | Issue 5/2018

Abstract

Purpose of Review

To succinctly summarize recent findings concerning dormancy regulating interactions between bone marrow stromal cells and disseminated tumor cells.

Recent Findings

Recent studies have highlighted roles of the bone marrow microenviroment, including osteoblasts, mesenchymal stem cells (MSCs), and endothelial cells, in inducing or maintaining cancer cell dormancy. Key pathways of interest include: osteoblast-induced transforming growth factor (TGF)-β2 signaling, transfer of MSC-derived exosomes containing dormancy inducing microRNA, cancer cell cannibalism of MSCs, and endothelial cell secretion of thrombospondin 1 (TSP1).

Summary

The bone marrow is a common site of metastatic disease recurrence following a period of cancer cell dormancy. Understanding why disseminated tumor cells enter into dormancy and later resume cell proliferation and growth is vital to developing effective therapeutics against these cells. The bone marrow stroma and the various pathways through which it participates in crosstalk with cancer cells are essential to furthering understanding of how dormancy is regulated.

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Title: Interactions Between Disseminated Tumor Cells and Bone Marrow Stromal Cells Regulate Tumor Dormancy
Authors: D. Brooke Widner
Sun H. Park
Matthew R. Eber
Yusuke Shiozawa
Publication date: 01-10-2018
Publisher: Springer US
Published in: Current Osteoporosis Reports / Issue 5/2018
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-018-0471-7

ACC 2024 Congress

Springer Medicine

Interactions Between Disseminated Tumor Cells and Bone Marrow Stromal Cells Regulate Tumor Dormancy

Abstract

Purpose of Review

Recent Findings

Summary

ACC 2024 Congress

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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