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01-10-2018 | Regenerative Biology and Medicine in Osteoporosis (T Webster, Section Editor)

Carbon Nanomaterials for Treating Osteoporotic Vertebral Fractures

Authors: Jancineide Oliveira de Carvalho, Francilio de Carvalho Oliveira, Sérgio Antonio Pereira Freitas, Liana Martha Soares, Rita de Cássia Barros Lima, Licia de Sousa Gonçalves, Thomas Jay Webster, Fernanda Roberta Marciano, Anderson Oliveira Lobo

Published in: Current Osteoporosis Reports | Issue 5/2018

Abstract

Purpose of Review

To identify the use of carbon nanomaterials in bone regeneration and present new data on the regenerative capacity of bone tissue in osteopenic rats treated with graphene nanoribbons (GNRs).

Recent Findings

The results show that the physical and chemical properties of the nanomaterials are suitable for the fabrication of scaffolds intended for bone regeneration. The in vitro tests suggested a non-toxicity of the GNRs as well as improved biocompatibility and bone mineralization activity.

Summary

Here, for the first time, we evaluated the potential of GNRs in remodeling and repairing bone defects in osteoporotic animal models in vivo. Interestingly, bone mineralization and the initiation of the remodeling cycle by osteoclasts/osteoblasts were observed after the implantation of GNRs, thus implying healthy bone remodeling when using GNRs. This study, therefore, has opened our perspectives and certainly calls for more attention to the use of carbon nanomaterials for a wide range of osteoporosis applications.

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Title: Carbon Nanomaterials for Treating Osteoporotic Vertebral Fractures
Authors: Jancineide Oliveira de Carvalho
Francilio de Carvalho Oliveira
Sérgio Antonio Pereira Freitas
Liana Martha Soares
Rita de Cássia Barros Lima
Licia de Sousa Gonçalves
Thomas Jay Webster
Fernanda Roberta Marciano
Anderson Oliveira Lobo
Publication date: 01-10-2018
Publisher: Springer US
Published in: Current Osteoporosis Reports / Issue 5/2018
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-018-0476-2

At a glance: The STEP trials

Springer Medicine

Carbon Nanomaterials for Treating Osteoporotic Vertebral Fractures

Abstract

Purpose of Review

Recent Findings

Summary

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose of Review

Recent Findings

Summary

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