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Current Osteoporosis Reports
Published in: Current Osteoporosis Reports 4/2018

01-08-2018 | Orthopedic Management of Fractures (S Bukata and L Gerstenfeld, Section Editors)

Origin of Reparative Stem Cells in Fracture Healing

Authors: Beth C. Bragdon, Chelsea S. Bahney

Published in: Current Osteoporosis Reports | Issue 4/2018

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Abstract

Purpose of Review

The identity and functional roles of stem cell population(s) that contribute to fracture repair remains unclear. This review provides a brief history of mesenchymal stem cell (MSCs) and provides an updated view of the many stem/progenitor cell populations contributing to fracture repair.

Recent Findings

Functional studies show MSCs are not the multipotential stem cell population that form cartilage and bone during fracture repair. Rather, multiple studies have confirmed the periosteum is the primary source of stem/progenitor cells for fracture repair. Newer work is also identifying other stem/progenitor cells that may also contribute to healing.

Summary

Although the heterogenous periosteal cells migrate to the fracture site and contribute directly to callus formation, other cell populations are involved. Pericytes and bone marrow stromal cells are now thought of as key secretory centers that mostly coordinate the repair process. Other populations of stem/progenitor cells from the muscle and transdifferentiated chondroctyes may also contribute to repair, and their functional role is an area of active research.
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Metadata
Title
Origin of Reparative Stem Cells in Fracture Healing
Authors
Beth C. Bragdon
Chelsea S. Bahney
Publication date
01-08-2018
Publisher
Springer US
Published in
Current Osteoporosis Reports / Issue 4/2018
Print ISSN: 1544-1873
Electronic ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-018-0458-4

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