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Published in: Current Oncology Reports 1/2011

01-02-2011

Prostate Cancer Screening

Authors: Elise D. Cook, Ana C. Nelson

Published in: Current Oncology Reports | Issue 1/2011

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Abstract

Prostate cancer is the most common cancer and the second leading cause of cancer-related deaths in American men. Although the use of the prostate-specific antigen (PSA) test for prostate cancer screening since the 1990s has led to increased early diagnoses, the most recent studies are in conflict about the risks and benefits of routine prostate cancer screening. Recently, evidence has emerged to support the use of the PSA test to lower mortality, but there is still concern that over-diagnosis may lead to over-treatment of cancers that would not significantly affect patients’ health for several years. This article describes the results of important recent prostate cancer screening trials, the National Comprehensive Cancer Network and American Cancer Society screening guidelines, and discusses the implications for clinical practice.
Literature
1.
go back to reference •• Hugosson J, Carlsson S, Aus G, et al.: Mortality results from the Goteborg randomized population-based prostate-cancer screening trial. Lancet Oncol 2010, 11:725–732. The Goteborg study’s first report on cumulative prostate cancer incidence and mortality demonstrated a significant reduction in prostate cancer mortality over a 14-year period, and the benefit of prostate cancer screening compared favorably to that of other cancer screenings. CrossRefPubMed •• Hugosson J, Carlsson S, Aus G, et al.: Mortality results from the Goteborg randomized population-based prostate-cancer screening trial. Lancet Oncol 2010, 11:725–732. The Goteborg study’s first report on cumulative prostate cancer incidence and mortality demonstrated a significant reduction in prostate cancer mortality over a 14-year period, and the benefit of prostate cancer screening compared favorably to that of other cancer screenings. CrossRefPubMed
2.
go back to reference •• Schroder FH, Hugosson J, Roobol MJ, et al.: Screening and prostate-cancer mortality in a randomized European study. N Eng J Med 2009, 360:1320–1328. Data from the ERSPC trial showed that PSA-based screening decreased the prostate cancer-related mortality rate by 20%. CrossRef •• Schroder FH, Hugosson J, Roobol MJ, et al.: Screening and prostate-cancer mortality in a randomized European study. N Eng J Med 2009, 360:1320–1328. Data from the ERSPC trial showed that PSA-based screening decreased the prostate cancer-related mortality rate by 20%. CrossRef
3.
5.
go back to reference Catalona WJ, Smith DS, Ratliff TL, et al.: Measurement of prostate-specific antigen in serum as a screening test for prostate cancer. N Eng J Med 1991, 324:1156–1161.CrossRef Catalona WJ, Smith DS, Ratliff TL, et al.: Measurement of prostate-specific antigen in serum as a screening test for prostate cancer. N Eng J Med 1991, 324:1156–1161.CrossRef
6.
go back to reference Wolf A, Wender RC, Etzioni RB, et al.: American Cancer Society Guideline for the Early Detection of Prostate Cancer: Update 2010. CA Cancer J Clin 2010, 60:70–98.CrossRefPubMed Wolf A, Wender RC, Etzioni RB, et al.: American Cancer Society Guideline for the Early Detection of Prostate Cancer: Update 2010. CA Cancer J Clin 2010, 60:70–98.CrossRefPubMed
8.
go back to reference Mills GB, Reiger PT: Genetic predisposition to breast cancer. In Breast Cancer. Edited by Hunt KK, Robb GL, Strom EA, Ueno NT. New York: Springer-Verlag; 2001:55–82. Mills GB, Reiger PT: Genetic predisposition to breast cancer. In Breast Cancer. Edited by Hunt KK, Robb GL, Strom EA, Ueno NT. New York: Springer-Verlag; 2001:55–82.
9.
go back to reference Thompson IM, Ankerst DP, Chi C, et al.: Assessing prostate cancer risk: results from the Prostate Cancer Prevention Trial. J Natl Cancer Inst 2006, 98:529–534.CrossRefPubMed Thompson IM, Ankerst DP, Chi C, et al.: Assessing prostate cancer risk: results from the Prostate Cancer Prevention Trial. J Natl Cancer Inst 2006, 98:529–534.CrossRefPubMed
10.
go back to reference •• Andriole, GL, Crawford ED, Grubb RL, et al.: Mortality results from a randomized prostate-cancer screening trial. N Eng J Med 2009, 360:1310–1319. The PLCO cancer screening trial in the United States did not demonstrate a statistically significant reduction in prostate cancer-related mortality in men randomized to receive PSA and DRE screening. CrossRef •• Andriole, GL, Crawford ED, Grubb RL, et al.: Mortality results from a randomized prostate-cancer screening trial. N Eng J Med 2009, 360:1310–1319. The PLCO cancer screening trial in the United States did not demonstrate a statistically significant reduction in prostate cancer-related mortality in men randomized to receive PSA and DRE screening. CrossRef
11.
go back to reference Esserman L, Shieh Y, Thompson I: Rethinking screening for breast cancer and prostate cancer. JAMA 2009, 302:1685–1692.CrossRefPubMed Esserman L, Shieh Y, Thompson I: Rethinking screening for breast cancer and prostate cancer. JAMA 2009, 302:1685–1692.CrossRefPubMed
12.
go back to reference Draisma G, Etzioni R, Tsodikov A, et al.: Lead time and over-diagnosis in prostate-specific antigen screening: importance of methods of context. J Natl Cancer Inst 2009, 101:374–383.CrossRefPubMed Draisma G, Etzioni R, Tsodikov A, et al.: Lead time and over-diagnosis in prostate-specific antigen screening: importance of methods of context. J Natl Cancer Inst 2009, 101:374–383.CrossRefPubMed
13.
go back to reference Hakama M, Coleman MP, Alexe DM, Auvinen A: Cancer screening: evidence and practice in Europe 2008. Eur J Cancer 2008, 44:1404–1413.CrossRefPubMed Hakama M, Coleman MP, Alexe DM, Auvinen A: Cancer screening: evidence and practice in Europe 2008. Eur J Cancer 2008, 44:1404–1413.CrossRefPubMed
14.
go back to reference Essink-Bot ML, de Koning HJ, Nijs HG, et al.: Short term effects of population-based screening for prostate cancer on health-related quality of life. J Natl Cancer Inst 1998, 90:925–931.CrossRefPubMed Essink-Bot ML, de Koning HJ, Nijs HG, et al.: Short term effects of population-based screening for prostate cancer on health-related quality of life. J Natl Cancer Inst 1998, 90:925–931.CrossRefPubMed
15.
go back to reference Fowler FJ Jr, Barry MJ, Walker-Corkery B, et al.: The impact of suspicious prostate biopsy on patients’ psychological, socio-behavioral, and medical care outcomes. J Gen Intern Med 2006, 21:715–721.CrossRefPubMed Fowler FJ Jr, Barry MJ, Walker-Corkery B, et al.: The impact of suspicious prostate biopsy on patients’ psychological, socio-behavioral, and medical care outcomes. J Gen Intern Med 2006, 21:715–721.CrossRefPubMed
16.
go back to reference Roberts RO, Bergstralh EJ, Besse JA, et al.: Trends and risk factors for biopsy complications in the pre-PSA and PSA eras, 1980 to 1997. Urology 2002, 59:79–84.CrossRefPubMed Roberts RO, Bergstralh EJ, Besse JA, et al.: Trends and risk factors for biopsy complications in the pre-PSA and PSA eras, 1980 to 1997. Urology 2002, 59:79–84.CrossRefPubMed
17.
go back to reference Djavan B, Zlotta A, Remzi M, et al.: Optimal predictors of cancer on repeat prostate biopsy: a prospective study of 1,051 men. J Urol 2000, 163:1144–1148; discussion 1148–1149.CrossRefPubMed Djavan B, Zlotta A, Remzi M, et al.: Optimal predictors of cancer on repeat prostate biopsy: a prospective study of 1,051 men. J Urol 2000, 163:1144–1148; discussion 1148–1149.CrossRefPubMed
18.
go back to reference Hu JC, Gu Xiangmei GU, Lipsitz SR, et al.: Comparative effectiveness of minimally invasive vs open radical prostatectomy. JAMA 2009, 302:1557–1564.CrossRefPubMed Hu JC, Gu Xiangmei GU, Lipsitz SR, et al.: Comparative effectiveness of minimally invasive vs open radical prostatectomy. JAMA 2009, 302:1557–1564.CrossRefPubMed
19.
go back to reference Elliot SP, Meng MV, Elkin EP, et al.: Incidence of urethral stricture after primary treatment for prostate cancer: data from CaPSURE. J Urol 2007, 178:529–534; discussion 534.CrossRef Elliot SP, Meng MV, Elkin EP, et al.: Incidence of urethral stricture after primary treatment for prostate cancer: data from CaPSURE. J Urol 2007, 178:529–534; discussion 534.CrossRef
21.
go back to reference National Comprehensive Cancer Network: NCCN Clinical Practice Guidelines in Oncology: Prostate Cancer Early Detection v.2.2010. Available at http://www.nccn.org. Accessed August 5, 2010. National Comprehensive Cancer Network: NCCN Clinical Practice Guidelines in Oncology: Prostate Cancer Early Detection v.2.2010. Available at http://​www.​nccn.​org. Accessed August 5, 2010.
22.
go back to reference Eyre SJ, Ankerst DP, Wei JT, et al.: Validation in a multiple urology practice cohort of Prostate Cancer Prevention Trial calculator for predicting cancer detection. J Urol 2009, 182:2653–2658.CrossRefPubMed Eyre SJ, Ankerst DP, Wei JT, et al.: Validation in a multiple urology practice cohort of Prostate Cancer Prevention Trial calculator for predicting cancer detection. J Urol 2009, 182:2653–2658.CrossRefPubMed
23.
go back to reference Parekh DJ, Ankerst DP, Higgins BA, et al.: External validation of the Cancer Prevention Trial risk calculator in screened population. Urology 2006, 68:1152–1155.CrossRefPubMed Parekh DJ, Ankerst DP, Higgins BA, et al.: External validation of the Cancer Prevention Trial risk calculator in screened population. Urology 2006, 68:1152–1155.CrossRefPubMed
24.
go back to reference Ankerst DP, Groskopt J, Day JR, et al.: Predicting prostate cancer risk through incorporation of cancer gene 3. J Urol 2008, 180:1303–1308; discussion 1308. CrossRefPubMed Ankerst DP, Groskopt J, Day JR, et al.: Predicting prostate cancer risk through incorporation of cancer gene 3. J Urol 2008, 180:1303–1308; discussion 1308. CrossRefPubMed
25.
go back to reference Carter HB, Pearson JD, Metter EJ, et al.: Longitudinal evaluation of prostate-specific antigen levels in men with and without disease. JAMA 1992, 267:2215–2220.CrossRefPubMed Carter HB, Pearson JD, Metter EJ, et al.: Longitudinal evaluation of prostate-specific antigen levels in men with and without disease. JAMA 1992, 267:2215–2220.CrossRefPubMed
26.
go back to reference Carter HB, Ferrucci L, Kettermann A, et al.: Detection of life-threatening cancer with prostate-specific antigen velocity during a window of curability. J Natl Cancer Inst 2006, 98:1521–1527.CrossRefPubMed Carter HB, Ferrucci L, Kettermann A, et al.: Detection of life-threatening cancer with prostate-specific antigen velocity during a window of curability. J Natl Cancer Inst 2006, 98:1521–1527.CrossRefPubMed
Metadata
Title
Prostate Cancer Screening
Authors
Elise D. Cook
Ana C. Nelson
Publication date
01-02-2011
Publisher
Current Science Inc.
Published in
Current Oncology Reports / Issue 1/2011
Print ISSN: 1523-3790
Electronic ISSN: 1534-6269
DOI
https://doi.org/10.1007/s11912-010-0136-x

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