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Keynote webinar | Spotlight on sleep in brain health

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Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
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Current Neurology and Neuroscience Reports
Published in: Current Neurology and Neuroscience Reports 7/2016

01-07-2016 | Sleep (M Thorpy and M Billiard Section Editors)

Melatonin for Sleep Disorders in Patients with Neurodegenerative Diseases

Authors: Lynn Marie Trotti, Elias G. Karroum

Published in: Current Neurology and Neuroscience Reports | Issue 7/2016

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Abstract

In patients with neurodegenerative diseases, sleep disorders are common; they impair the quality of life for patients and caregivers and are associated with poorer clinical outcomes. Melatonin has circadian, hypnotic, and free radical-scavenging effects, and preclinical data suggest benefits of melatonin on neurodegeneration. However, randomized, controlled trials of melatonin in patients with neurodegenerative diseases have not shown strong effects. Trials in Alzheimer’s patients demonstrate a lack of benefit on sleep quantity. Subjective measures of sleep quality are mixed, with possible symptomatic improvements seen only on some measures or at some time points. Benefits on cognition have not been observed across several studies. In Parkinson’s patients, there may be minimal benefit on objective sleep measures, but a suggestion of subjective benefit in few, small studies. Effective treatments for the sleep disorders associated with neurodegenerative diseases are urgently needed, but current data are insufficient to establish melatonin as such a treatment.
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Metadata
Title
Melatonin for Sleep Disorders in Patients with Neurodegenerative Diseases
Authors
Lynn Marie Trotti
Elias G. Karroum
Publication date
01-07-2016
Publisher
Springer US
Published in
Current Neurology and Neuroscience Reports / Issue 7/2016
Print ISSN: 1528-4042
Electronic ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-016-0664-3

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