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Current Infectious Disease Reports
Published in: Current Infectious Disease Reports 11/2014

01-11-2014 | Skin, Soft Tissue, Bone and Joint Infectious Diseases (N Safdar, Section Editor)

Mycobacterial Skin and Soft Tissue Infection

Authors: Shu-Hua Wang, Preeti Pancholi

Published in: Current Infectious Disease Reports | Issue 11/2014

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Abstract

Mycobacterial skin and soft tissue infection (SSTI) includes nontuberculous mycobacterial (NTM) infections, tuberculosis (TB), and leprosy. Diagnosis of mycobacterial SSTI can be challenging due to diverse clinical presentation, low yield from cultured specimens, and nonspecific histopathology on tissue biopsy. In addition, immunosuppressed patients may present with atypical or disseminated disease. Despite aggressive medical treatment and often with surgical intervention, results may be suboptimal with poor outcomes. Regimens typically require multiple antibiotics for extended periods of time and are often complicated by medication side effects and drug-drug interactions. Biopsy with culture is the gold standard for diagnosis, but newer molecular diagnostics and proteomics such as matrix-assisted laser desorption ionization-time of flight mass spectrometry have improved diagnosis with increased identification of clinically significant mycobacteria species in clinically relevant time frames. We will review updates in diagnostic tests along with clinical presentation and treatment of mycobacterial SSTI for NTM, TB, and leprosy.
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Metadata
Title
Mycobacterial Skin and Soft Tissue Infection
Authors
Shu-Hua Wang
Preeti Pancholi
Publication date
01-11-2014
Publisher
Springer US
Published in
Current Infectious Disease Reports / Issue 11/2014
Print ISSN: 1523-3847
Electronic ISSN: 1534-3146
DOI
https://doi.org/10.1007/s11908-014-0438-5

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