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Current Hypertension Reports
Published in: Current Hypertension Reports 9/2014

01-09-2014 | Preeclampsia (VD Garovic, Section Editor)

Maternal Preeclampsia and Risk for Cardiovascular Disease in Offspring

Authors: Guadalupe Herrera-Garcia, Stephen Contag

Published in: Current Hypertension Reports | Issue 9/2014

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Abstract

Hypertensive disease of pregnancy (HDP) has been associated with elevated lifetime cardiovascular risk, including stroke, myocardial disease, coronary artery disease, and peripheral arterial disease. These two entities share common risk factors such as obesity, insulin resistance, diabetes, and hypertension. This article will evaluate the current literature on the maternal and fetal cardiovascular risks posed by HDP. The landmark study by Barker et al. demonstrated increased cardiovascular risk in growth-restricted infants, which may also be associated with HDP. Research has demonstrated the effects that HDP may have on the vascular and nephron development in offspring, particularly with respect to endothelial and inflammatory markers. In order to control for confounding variables and better understand the relationship between HDP and lifetime cardiovascular risk, future research will require following blood pressure and metabolic profiles of the parturients and their offspring.
Literature
1.
CDC health disparities and inequalities report. United States, 2013, in MMWR Centers for Disease Control and Prevention: Atlanta, GA. 2013. p. 144–8.
2.
Go AS et al. Heart disease and stroke statistics–2014 update: a report from the American Heart Association. Circulation. 2014;129(3):e28–292.PubMedCrossRef
3.
Murphy SL, Xu J, Kochanek KD. Deaths: final data for 2010. National Vital Statistics Reports; 2014. p. 61.
4.
5.
Hauth JC et al. Pregnancy outcomes in healthy nulliparas who developed hypertension. Calcium for Preeclampsia Prevention Study Group. Obstet Gynecol. 2000;95(1):24–8.PubMedCrossRef
6.
Garovic VD, Hayman SR. Hypertension in pregnancy: an emerging risk factor for cardiovascular disease. Nat Clin Pract Nephrol. 2007;3(11):613–22.PubMedCrossRef
7.
Villar J et al. Preeclampsia, gestational hypertension and intrauterine growth restriction, related or independent conditions? Am J Obstet Gynecol. 2006;194(4):921–31.PubMedCrossRef
8.
Kvehaugen AS, Andersen LF, Staff AC. Anthropometry and cardiovascular risk factors in women and offspring after pregnancies complicated by preeclampsia or diabetes mellitus. Acta Obstet Gynecol Scand. 2010;89(11):1478–85.PubMedCrossRef
9.
Lykke JA et al. Hypertensive pregnancy disorders and subsequent cardiovascular morbidity and type 2 diabetes mellitus in the mother. Hypertension. 2009;53(6):944–51.PubMedCrossRef
10.
Ferreira I, Peeters LL, Stehouwer CD. Preeclampsia and increased blood pressure in the offspring: meta-analysis and critical review of the evidence. J Hypertens. 2009;27(10):1955–9.PubMedCrossRef
11.•
Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists’ Task Force on Hypertension in Pregnancy. Obstet Gynecol. 2013;122(5):1122–31. Revised ACOG hypertension in pregnancy definitions and management guidelines.
12.
Stuart JJ et al. Maternal recall of hypertensive disorders in pregnancy: a systematic review. J Womens Health (Larchmt). 2013;22(1):37–47.CrossRef
13.
Block-Abraham DM et al. First-trimester risk factors for preeclampsia development in women initiating aspirin by 16 weeks of gestation. Obstet Gynecol. 2014;123(3):611–7.PubMedCrossRef
14.
Bushnell C, et al. Guidelines for the prevention of stroke in women: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45:1545–88.
15.
16.
Cohen AL et al. The association of circulating angiogenic factors and HbA1c with the risk of preeclampsia in women with preexisting diabetes. Hypertens Pregnancy. 2014;33(1):81–92.PubMedCentralPubMedCrossRef
17.
18.
Magnussen EB et al. Hypertensive disorders in pregnancy and subsequently measured cardiovascular risk factors. Obstet Gynecol. 2009;114(5):961–70.PubMedCrossRef
19.
Marin R et al. Long-term prognosis of hypertension in pregnancy. Hypertens Pregnancy. 2000;19(2):199–209.PubMedCrossRef
20.
Wilson BJ et al. Hypertensive diseases of pregnancy and risk of hypertension and stroke in later life: results from cohort study. BMJ. 2003;326(7394):845.PubMedCentralPubMedCrossRef
21.
Sibai BM et al. Risk factors associated with preeclampsia in healthy nulliparous women. The Calcium for Preeclampsia Prevention (CPEP) Study Group. Am J Obstet Gynecol. 1997;177(5):1003–10.PubMedCrossRef
22.
Dunne F et al. Pregnancy in women with type 2 diabetes: 12 years outcome data 1990-2002. Diabet Med. 2003;20(9):734–8.PubMedCrossRef
23.
Hubel CA et al. Fasting serum triglycerides, free fatty acids, and malondialdehyde are increased in preeclampsia, are positively correlated, and decrease within 48 hours post partum. Am J Obstet Gynecol. 1996;174(3):975–82.PubMedCrossRef
24.
Al MD et al. The essential fatty acid status of mother and child in pregnancy-induced hypertension: a prospective longitudinal study. Am J Obstet Gynecol. 1995;172(5):1605–14.PubMedCrossRef
25.
Girouard J et al. Previous hypertensive disease of pregnancy is associated with alterations of markers of insulin resistance. Hypertension. 2007;49(5):1056–62.PubMedCrossRef
26.
Callaway LK et al. Diabetes mellitus in the 21 years after a pregnancy that was complicated by hypertension: findings from a prospective cohort study. Am J Obstet Gynecol. 2007;197(5):492.e1–7.CrossRef
27.
Carr DB et al. Preeclampsia and risk of developing subsequent diabetes. Hypertens Pregnancy. 2009;28(4):435–47.PubMedCrossRef
28.
Libby G et al. Pre-eclampsia and the later development of type 2 diabetes in mothers and their children: an intergenerational study from the Walker cohort. Diabetologia. 2007;50(3):523–30.PubMedCrossRef
29.•
Valdiviezo C, Garovic VD, Ouyang P. Preeclampsia and hypertensive disease in pregnancy: their contributions to cardiovascular risk. Clin Cardiol. 2012;35(3):160–5. Review article evaluated the maternal cardiovascular risks in patients who had hypertensive disorder in pregnancy.PubMedCrossRef
30.
Bellamy L et al. Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ. 2007;335(7627):974.PubMedCentralPubMedCrossRef
31.
McDonald SD et al. Cardiovascular sequelae of preeclampsia/eclampsia: a systematic review and meta-analyses. Am Heart J. 2008;156(5):918–30.PubMedCrossRef
32.
Agatisa PK et al. Impairment of endothelial function in women with a history of preeclampsia: an indicator of cardiovascular risk. Am J Physiol Heart Circ Physiol. 2004;286(4):H1389–93.PubMedCrossRef
33.
Lampinen KH et al. Impaired vascular dilatation in women with a history of pre-eclampsia. J Hypertens. 2006;24(4):751–6.PubMedCrossRef
34.
Ramsay JE et al. Microvascular dysfunction: a link between pre-eclampsia and maternal coronary heart disease. BJOG. 2003;110(11):1029–31.PubMedCrossRef
35.
Jayet PY et al. Pulmonary and systemic vascular dysfunction in young offspring of mothers with preeclampsia. Circulation. 2010;122(5):488–94.PubMedCrossRef
36.•
Sandvik MK et al. Preeclampsia in healthy women and endothelial dysfunction 10 years later. Am J Obstet Gynecol. 2013;209(6):569.e1–569.e10. Prospective study that evaluated flow-mediated brachial artery dilation and intima-media thickness of the carotid artery along with circulating markers of endothelial function. Found that endothelial function was altered in patients with preeclampsia compared to control cohort.CrossRef
37.•
Staff AC, Dechend R, Redman CW. Review: Preeclampsia, acute atherosis of the spiral arteries and future cardiovascular disease: two new hypotheses. Placenta. 2013;34(Suppl):S73–8. Review article that evaluated increased risk for atherosclerosis and later chronic arterial disease in patients with preeclampsia.PubMedCrossRef
38.
ACOG Practice Bulletin No. 134: fetal growth restriction. Obstet Gynecol. 2013;121(5):1122–33.
39.
Barker DJ, Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet. 1986;1(8489):1077–81.PubMedCrossRef
40.
Conde-Agudelo A et al. Novel biomarkers for predicting intrauterine growth restriction: a systematic review and meta-analysis. BJOG. 2013;120(6):681–94.PubMedCrossRef
41.
Davis EF et al. Cardiovascular risk factors in children and young adults born to preeclamptic pregnancies: a systematic review. Pediatrics. 2012;129(6):e1552–61.PubMedCrossRef
42.
Gaillard R et al. Placental vascular dysfunction, fetal and childhood growth, and cardiovascular development: the generation R study. Circulation. 2013;128(20):2202–10.PubMedCrossRef
43.
Gebb J, Dar P. Colour Doppler ultrasound of spiral artery blood flow in the prediction of pre-eclampsia and intrauterine growth restriction. Best Pract Res Clin Obstet Gynaecol. 2011;25(3):355–66.PubMedCrossRef
44.
Mu M et al. Birth weight and subsequent blood pressure: a meta-analysis. Arch Cardiovasc Dis. 2012;105(2):99–113.PubMedCrossRef
45.
Ojeda NB, Grigore D, Alexander BT. Developmental programming of hypertension: insight from animal models of nutritional manipulation. Hypertension. 2008;52(1):44–50.PubMedCentralPubMedCrossRef
46.
Spence D et al. Intra-uterine growth restriction and increased risk of hypertension in adult life: a follow-up study of 50-year-olds. Public Health. 2012;126(7):561–5.PubMedCrossRef
47.
Poston L, Hanson M. Developmental origins of health and disease. In: Creasy RR, Greene MF, Iams JD, Lockwood CJ, Moore TR, editors. Creasy and Resnik's maternal-fetal medicine : principles and practice. Philadelphia: Elsevier/Saunders; 2014. p. 139–45.
48.
Barker DJP. Fetal origins of adult disease. In: Polin WWFRA, Abman S, editors. Fetal and neonatal physiology. Philadelphia: W.B. Saunders; 2004. p. 160–5.CrossRef
49.
50.
51.
Szostak-Wegierek D, Szamotulska K. Fetal development and risk of cardiovascular diseases and diabetes type 2 in adult life. Med Wieku Rozwoj. 2011;15(3):203–15.PubMed
52.
53.
Anderson CM et al. Placental insufficiency leads to developmental hypertension and mesenteric artery dysfunction in two generations of Sprague-Dawley rat offspring. Biol Reprod. 2006;74(3):538–44.PubMedCrossRef
54.
Ness RB, Catov J. Invited commentary: timing and types of cardiovascular risk factors in relation to offspring birth weight. Am J Epidemiol. 2007;166(12):1365–7.PubMedCrossRef
55.
Nenov VD et al. Multi-hit nature of chronic renal disease. Curr Opin Nephrol Hypertens. 2000;9(2):85–97.PubMedCrossRef
56.
Contag SA et al. Developmental effect of antenatal exposure to betamethasone on renal angiotensin II activity in the young adult sheep. Am J Physiol Renal Physiol. 2010;298(4):F847–56.PubMedCentralPubMedCrossRef
57.
Goddard KA et al. Candidate-gene association study of mothers with pre-eclampsia, and their infants, analyzing 775 SNPs in 190 genes. Hum Hered. 2007;63(1):1–16.PubMedCrossRef
58.••
Millis RM. Epigenetics and hypertension. Curr Hypertens Rep. 2011;13(1):21–8. Review article that evaluates the evidence for epigenetic contributions to hypertension and complex environment and gene interactions that may explain the wide diversity of health and disease.PubMedCrossRef
59.••
Anderson CM, et al. DNA methylation as a biomarker for preeclampsia. Biol Res Nurs. 2013. doi:10.​1177/​1099800413508645​. Prospective study, one of the first to identify maternal epigenetic targets in fetal-derived tissue representing biomarkers for early detection and heritable risk of preeclampsia.
60.
Koleganova N, Piecha G, Ritz E. Prenatal causes of kidney disease. Blood Purif. 2009;27(1):48–52.PubMedCrossRef
61.•
Boyd HA et al. Associations of personal and family preeclampsia history with the risk of early-, intermediate- and late-onset preeclampsia. Am J Epidemiol. 2013;178(11):1611–9. Large Denmark study that showed strong familial associations for early- and intermediate-onset of preeclampsia in female relatives with strongest association in early-onset preeclampsia.PubMedCrossRef
62.
Arngrimsson R et al. Genetic and familial predisposition to eclampsia and pre-eclampsia in a defined population. Br J Obstet Gynaecol. 1990;97(9):762–9.PubMedCrossRef
63.
Myklestad K et al. Hypertensive disorders in pregnancy and paternal cardiovascular risk: a population-based study. Ann Epidemiol. 2011;21(6):407–12.PubMedCrossRef
64.
Lazdam M et al. Unique blood pressure characteristics in mother and offspring after early onset preeclampsia. Hypertension. 2012;60(5):1338–45.PubMedCrossRef
65.
Resnik R, Creasy R. Intrauterine growth restriction. In: Creasy R, Greene MF, Iams JD, Lockwood CJ, Moore TR, editors. Creasy & Resnik’s maternal-fetal medicine: principles and practice. Philadelphia: Elsiever Saunders; 2014. p. 743–55.
66.
Ahmad AS, Samuelsen SO. Hypertensive disorders in pregnancy and fetal death at different gestational lengths: a population study of 2 121 371 pregnancies. BJOG. 2012;119(12):1521–8.PubMedCrossRef
67.
Zetterstrom K et al. The association of maternal chronic hypertension with perinatal death in male and female offspring: a record linkage study of 866,188 women. BJOG. 2008;115(11):1436–42.PubMedCrossRef
68.•
Mamun AA et al. Does hypertensive disorder of pregnancy predict offspring blood pressure at 21 years? Evidence from a birth cohort study. J Hum Hypertens. 2012;26(5):288–94. Large cohort study that found that maternal hypertensive disorder of pregnancy predicts adult offspring blood pressure.PubMedCrossRef
69.
70.
71.
Oglaend B et al. Blood pressure in early adolescence in the offspring of preeclamptic and normotensive pregnancies. J Hypertens. 2009;27(10):2051–4.PubMedCrossRef
72.
Smith GD et al. Birth dimensions of offspring, premature birth, and the mortality of mothers. Lancet. 2000;356(9247):2066–7.PubMedCrossRef
73.
Catov JM et al. Association between infant birth weight and maternal cardiovascular risk factors in the health, aging, and body composition study. Ann Epidemiol. 2007;17(1):36–43.PubMedCrossRef
74.
Romundstad PR et al. Associations of prepregnancy cardiovascular risk factors with the offspring's birth weight. Am J Epidemiol. 2007;166(12):1359–64.PubMedCrossRef
75.
Langford HG, Watson RL. Prepregnant blood pressure, hypertension during pregnancy, and later blood pressure of mothers and offspring. Hypertension. 1980;2(4 Pt 2):130–3.PubMedCrossRef
76.
Zetterstrom K et al. Chronic hypertension as a risk factor for offspring to be born small for gestational age. Acta Obstet Gynecol Scand. 2006;85(9):1046–50.PubMedCrossRef
77.
Bujold E et al. Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis. Obstet Gynecol. 2010;116(2 Pt 1):402–14.PubMedCrossRef
78.
Geyl C, et al. Links between preeclampsia and intrauterine growth restriction. Gynecol Obstet Fertil. 2014;42(4):229–33.
79.
Weiler J, Tong S, Palmer KR. Is fetal growth restriction associated with a more severe maternal phenotype in the setting of early onset pre-eclampsia? A retrospective study. PLoS One. 2011;6(10):e26937.PubMedCentralPubMedCrossRef
80.•
Burton GJ, Charnock-Jones DS, Jauniaux E. Regulation of vascular growth and function in the human placenta. Reproduction. 2009;138(6):895–902. Placental deficient conversion of the maternal spiral arteries is associated with the majority of pregnancy complications including preeclampsia. This effect increases the risk of spontaneous vasoconstriction of the arteries, and predisposes the placenta to ischemia reperfusion-type injury.PubMedCrossRef
81.
Markham KB, FE. Pregnancy related hypertension. In: Creasy R, Greene MF, Iams JD, Lockwood CJ, Moore TR, editors. Creasy and Resnik's maternal-fetal medicine: principles and practice. Elsiever Saunders: Philadelphia; 2014. p. 756–81.
82.
Brosens IA, Robertson WB, Dixon HG. The role of the spiral arteries in the pathogenesis of preeclampsia. Obstet Gynecol Annu. 1972;1:177–91.PubMed
83.
84.
Kajantie E et al. Pre-eclampsia is associated with increased risk of stroke in the adult offspring: the Helsinki birth cohort study. Stroke. 2009;40(4):1176–80.PubMedCrossRef
85.
Miettola S et al. Offspring's blood pressure and metabolic phenotype after exposure to gestational hypertension in utero. Eur J Epidemiol. 2013;28(1):87–98.PubMedCrossRef
86.
Fugelseth D et al. Myocardial function in offspring 5-8 years after pregnancy complicated by preeclampsia. Early Hum Dev. 2011;87(8):531–5.PubMedCrossRef
87.
Wu CS et al. Diseases in children born to mothers with preeclampsia: a population-based sibling cohort study. Am J Obstet Gynecol. 2011;204(2):157.e1–5.CrossRef
88.
Lawlor DA et al. Cardiovascular biomarkers and vascular function during childhood in the offspring of mothers with hypertensive disorders of pregnancy: findings from the Avon Longitudinal Study of Parents and Children. Eur Heart J. 2012;33(3):335–45.PubMedCentralPubMedCrossRef
89.
Kvehaugen AS et al. Endothelial function and circulating biomarkers are disturbed in women and children after preeclampsia. Hypertension. 2011;58(1):63–9.PubMedCrossRef
90.
Whitehouse AJ et al. Do hypertensive diseases of pregnancy disrupt neurocognitive development in offspring? Paediatr Perinat Epidemiol. 2012;26(2):101–8.PubMedCrossRef
91.
Tuovinen S et al. Hypertensive disorders in pregnancy and risk of severe mental disorders in the offspring in adulthood: the Helsinki Birth Cohort Study. J Psychiatr Res. 2012;46(3):303–10.PubMedCrossRef
92.
Robinson M et al. Hypertensive diseases of pregnancy and the development of behavioral problems in childhood and adolescence: the Western Australian Pregnancy Cohort Study. J Pediatr. 2009;154(2):218–24.PubMedCrossRef
93.
Palti H, Rothschild E. Blood pressure and growth at 6 years of age among offsprings of mothers with hypertension of pregnancy. Early Hum Dev. 1989;19(4):263–9.PubMedCrossRef
94.
Vatten LJ et al. Intrauterine exposure to preeclampsia and adolescent blood pressure, body size, and age at menarche in female offspring. Obstet Gynecol. 2003;101(3):529–33.PubMedCrossRef
95.
Seidman DS et al. Pre-eclampsia and offspring's blood pressure, cognitive ability and physical development at 17-years-of-age. Br J Obstet Gynaecol. 1991;98(10):1009–14.PubMedCrossRef
96.
Tenhola S et al. Blood pressure, serum lipids, fasting insulin, and adrenal hormones in 12-year-old children born with maternal preeclampsia. J Clin Endocrinol Metab. 2003;88(3):1217–22.PubMedCrossRef
97.
Ophir E et al. Newborns of pre-eclamptic women: a biochemical difference present in utero. Acta Obstet Gynecol Scand. 2006;85(10):1172–8.PubMedCrossRef
98.
Palmsten K, Buka SL, Michels KB. Maternal pregnancy-related hypertension and risk for hypertension in offspring later in life. Obstet Gynecol. 2010;116(4):858–64.PubMedCentralPubMedCrossRef
99.••
Geelhoed JJ et al. Preeclampsia and gestational hypertension are associated with childhood blood pressure independently of family adiposity measures: the Avon Longitudinal Study of Parents and Children. Circulation. 2010;122(12):1192–9. One of the largest prospective cohort studies to evaluate the association between hypertensive disorders of pregnancy blood pressure of offspring.PubMedCrossRef
Metadata
Title
Maternal Preeclampsia and Risk for Cardiovascular Disease in Offspring
Authors
Guadalupe Herrera-Garcia
Stephen Contag
Publication date
01-09-2014
Publisher
Springer US
Published in
Current Hypertension Reports / Issue 9/2014
Print ISSN: 1522-6417
Electronic ISSN: 1534-3111
DOI
https://doi.org/10.1007/s11906-014-0475-3

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