Skip to main content
Top
Published in: Current HIV/AIDS Reports 4/2018

01-08-2018 | The Global Epidemic (SH Vermund, Section Editor)

HIV/HCV Co-infection: Burden of Disease and Care Strategies in Appalachia

Authors: Jonathan P. Moorman, Matthew R. Krolikowski, Stephanie M. Mathis, Robert P. Pack

Published in: Current HIV/AIDS Reports | Issue 4/2018

Login to get access

Abstract

Purpose of Review

The purpose of this review is to address infection with HIV and hepatitis C in the Appalachian region of the USA and the driving forces underlying this epidemic. We seek to discuss epidemiology of disease and the possible interventions to reduce incidence and burden of disease in this resource-limited area.

Recent Findings

The rise of the opioid crisis has fueled a rise in new hepatitis C infection, and a rise in new HIV infection is expected to follow. Injection drug use has directly contributed to the epidemic and continues to remain a risk factor. Men who have sex with men remains a significant risk factor for HIV acquisition as well.

Summary

Progress has been made in the battle against HIV and, to a lesser extent, hepatitis C, but much more can be done. Limited data on co-infection with HIV/HCV are currently available for this at-risk region, but it is clear that Appalachia is highly vulnerable to co-infection outbreaks. A multipronged approach that includes advances in assessment of co-infection and education for both patients and clinicians can help to recognize, manage, and ideally prevent these illnesses.
Literature
2.
go back to reference Yao N, Alcala HE, Anderson R, Balkrishnan R. Cancer disparities in rural Appalachia: incidence, early detection, and survivorship. J Rural Health. 2017;33(4):375–81.CrossRefPubMed Yao N, Alcala HE, Anderson R, Balkrishnan R. Cancer disparities in rural Appalachia: incidence, early detection, and survivorship. J Rural Health. 2017;33(4):375–81.CrossRefPubMed
3.
go back to reference National Academies of Sciences E, and Medicine. In: Richard JB, Morgan AF, Jonathan KP, editors. Pain management and the opioid epidemic: Balancing societal and individual benefits and risks of prescription drug use. Washington, D.C.: National Academies Press; 2017. National Academies of Sciences E, and Medicine. In: Richard JB, Morgan AF, Jonathan KP, editors. Pain management and the opioid epidemic: Balancing societal and individual benefits and risks of prescription drug use. Washington, D.C.: National Academies Press; 2017.
4.
go back to reference Manchikanti L, Helm S 2nd, Fellows B, Janata JW, Pampati V, Grider JS, et al. Opioid epidemic in the United States. Pain Physician. 2012;15(3 Suppl):ES9–38.PubMed Manchikanti L, Helm S 2nd, Fellows B, Janata JW, Pampati V, Grider JS, et al. Opioid epidemic in the United States. Pain Physician. 2012;15(3 Suppl):ES9–38.PubMed
5.
go back to reference The opioid epidemic: from evidence to impact. Executive summary: America’s opioid epidemic: from evidence to impact. Alexander G, Frattaroli S, Gielen A, editor. Baltimore: Johns Hopkins Bloomberg School of Public Health; 2017. The opioid epidemic: from evidence to impact. Executive summary: America’s opioid epidemic: from evidence to impact. Alexander G, Frattaroli S, Gielen A, editor. Baltimore: Johns Hopkins Bloomberg School of Public Health; 2017.
6.
go back to reference Kolodny A, Courtwright DT, Hwang CS, Kreiner P, Eadie JL, Clark TW, et al. The prescription opioid and heroin crisis: a public health approach to an epidemic of addiction. Annu Rev Public Health. 2015;36:559–74.CrossRefPubMed Kolodny A, Courtwright DT, Hwang CS, Kreiner P, Eadie JL, Clark TW, et al. The prescription opioid and heroin crisis: a public health approach to an epidemic of addiction. Annu Rev Public Health. 2015;36:559–74.CrossRefPubMed
7.
go back to reference Rudd RA, Seth P, David F, Scholl L. Increases in drug and opioid-involved overdose deaths—United States, 2010-2015. MMWR Morb Mortal Wkly Rep. 2016;65(5051):1445–52.CrossRefPubMed Rudd RA, Seth P, David F, Scholl L. Increases in drug and opioid-involved overdose deaths—United States, 2010-2015. MMWR Morb Mortal Wkly Rep. 2016;65(5051):1445–52.CrossRefPubMed
8.
go back to reference Ahrnsbrak R, Bose J, Hedden S, Lipari R, Park-Lee R. Key substance use and mental health indicators in the United States: results from the 2016 National Survey on Drug Use and Health (HHS Publication No. SMA 17-5044, NSDUH Series H-52). In: Center for Behavioral Health Statistics and Quality Substance Abuse and Mental Health Services Administration (SAaMHSA), editor. Rockville, MD, 2017. Ahrnsbrak R, Bose J, Hedden S, Lipari R, Park-Lee R. Key substance use and mental health indicators in the United States: results from the 2016 National Survey on Drug Use and Health (HHS Publication No. SMA 17-5044, NSDUH Series H-52). In: Center for Behavioral Health Statistics and Quality Substance Abuse and Mental Health Services Administration (SAaMHSA), editor. Rockville, MD, 2017.
9.
go back to reference Jones CM. The paradox of decreasing nonmedical opioid analgesic use and increasing abuse or dependence—an assessment of demographic and substance use trends, United States, 2003-2014. Addict Behav. 2017;65:229–35.CrossRefPubMed Jones CM. The paradox of decreasing nonmedical opioid analgesic use and increasing abuse or dependence—an assessment of demographic and substance use trends, United States, 2003-2014. Addict Behav. 2017;65:229–35.CrossRefPubMed
10.
go back to reference McCabe SE, West BT, Veliz P, McCabe VV, Stoddard SA, Boyd CJ. Trends in medical and nonmedical use of prescription opioids among US adolescents: 1976–2015. Pediatrics. 2017;139(4):e20162387.CrossRefPubMedPubMedCentral McCabe SE, West BT, Veliz P, McCabe VV, Stoddard SA, Boyd CJ. Trends in medical and nonmedical use of prescription opioids among US adolescents: 1976–2015. Pediatrics. 2017;139(4):e20162387.CrossRefPubMedPubMedCentral
11.
go back to reference Dart RC, Severtson SG, Bucher-Bartelson B. Trends in opioid analgesic abuse and mortality in the United States. N Engl J Med. 2015;372(16):1573–4.PubMed Dart RC, Severtson SG, Bucher-Bartelson B. Trends in opioid analgesic abuse and mortality in the United States. N Engl J Med. 2015;372(16):1573–4.PubMed
12.
go back to reference Han B, Compton WM, Jones CM, Cai R. Nonmedical prescription opioid use and use disorders among adults aged 18 through 64 years in the United States, 2003-2013. JAMA. 2015;314(14):1468–78.CrossRefPubMed Han B, Compton WM, Jones CM, Cai R. Nonmedical prescription opioid use and use disorders among adults aged 18 through 64 years in the United States, 2003-2013. JAMA. 2015;314(14):1468–78.CrossRefPubMed
13.
go back to reference Lipari RN, Van Horn SL, Hughes A, Williams M. State and substate estimates of nonmedical use of prescription pain relievers. In: Center for Behavioral Health Statistics and Quality Substance Abuse and Mental Health Services Administration (SAaMHSA), editor. Rockville, MD, 2017 Lipari RN, Van Horn SL, Hughes A, Williams M. State and substate estimates of nonmedical use of prescription pain relievers. In: Center for Behavioral Health Statistics and Quality Substance Abuse and Mental Health Services Administration (SAaMHSA), editor. Rockville, MD, 2017
14.
go back to reference Martins SS, Sarvet A, Santaella-Tenorio J, Saha T, Grant BF, Hasin DS. Changes in US lifetime heroin use and heroin use disorder: prevalence from the 2001-2002 to 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions. JAMA Psychiatry. 2017;74(5):445–55.CrossRefPubMedPubMedCentral Martins SS, Sarvet A, Santaella-Tenorio J, Saha T, Grant BF, Hasin DS. Changes in US lifetime heroin use and heroin use disorder: prevalence from the 2001-2002 to 2012-2013 National Epidemiologic Survey on Alcohol and Related Conditions. JAMA Psychiatry. 2017;74(5):445–55.CrossRefPubMedPubMedCentral
15.
go back to reference Keyes KM, Cerda M, Brady JE, Havens JR, Galea S. Understanding the rural-urban differences in nonmedical prescription opioid use and abuse in the United States. Am J Public Health. 2014;104(2):e52–9.CrossRefPubMedPubMedCentral Keyes KM, Cerda M, Brady JE, Havens JR, Galea S. Understanding the rural-urban differences in nonmedical prescription opioid use and abuse in the United States. Am J Public Health. 2014;104(2):e52–9.CrossRefPubMedPubMedCentral
16.
go back to reference Zhang Z IA, Meit M, English N, Dunn M, Bowers K. An analysis of mental health and substance abuse disparities & access to treatment services in the Appalachian Region. In: Reports from the Appalachian Regional Commission. National Opinion Research Center (NORC) at the University of Chicago, and East Tennessee State University, editors. 2008. Zhang Z IA, Meit M, English N, Dunn M, Bowers K. An analysis of mental health and substance abuse disparities & access to treatment services in the Appalachian Region. In: Reports from the Appalachian Regional Commission. National Opinion Research Center (NORC) at the University of Chicago, and East Tennessee State University, editors. 2008.
17.
go back to reference Centers for Disease C, Prevention. CDC grand rounds: prescription drug overdoses—a U.S. epidemic. MMWR Morb Mortal Wkly Rep. 2012;61(1):10–3. Centers for Disease C, Prevention. CDC grand rounds: prescription drug overdoses—a U.S. epidemic. MMWR Morb Mortal Wkly Rep. 2012;61(1):10–3.
18.
go back to reference Moody L, Satterwhite E, Bickel WK. Substance use in rural central Appalachia: current status and treatment considerations. Rural Ment Health. 2017;41(2):123–35.CrossRefPubMedPubMedCentral Moody L, Satterwhite E, Bickel WK. Substance use in rural central Appalachia: current status and treatment considerations. Rural Ment Health. 2017;41(2):123–35.CrossRefPubMedPubMedCentral
19.
go back to reference Suryaprasad AG, White JZ, Xu F, Eichler BA, Hamilton J, Patel A, et al. Emerging epidemic of hepatitis C virus infections among young nonurban persons who inject drugs in the United States, 2006-2012. Clin Infect Dis. 2014;59(10):1411–9.CrossRefPubMed Suryaprasad AG, White JZ, Xu F, Eichler BA, Hamilton J, Patel A, et al. Emerging epidemic of hepatitis C virus infections among young nonurban persons who inject drugs in the United States, 2006-2012. Clin Infect Dis. 2014;59(10):1411–9.CrossRefPubMed
20.
go back to reference Love MM, Cohn TJ, Pierce TW, Hastings SL. Trends in injection use among prescription opioid-misusing individuals in the rural United States. Rural Ment Health. 2016;40(3–4):180–92.CrossRef Love MM, Cohn TJ, Pierce TW, Hastings SL. Trends in injection use among prescription opioid-misusing individuals in the rural United States. Rural Ment Health. 2016;40(3–4):180–92.CrossRef
21.
go back to reference Young AM, Havens JR, Leukefeld CG. A comparison of rural and urban nonmedical prescription opioid users’ lifetime and recent drug use. Am J Drug Alcohol Abuse. 2012;38(3):220–7.CrossRefPubMed Young AM, Havens JR, Leukefeld CG. A comparison of rural and urban nonmedical prescription opioid users’ lifetime and recent drug use. Am J Drug Alcohol Abuse. 2012;38(3):220–7.CrossRefPubMed
22.
go back to reference Young AM, Havens JR, Leukefeld CG. Route of administration for illicit prescription opioids: a comparison of rural and urban drug users. Harm Reduct J. 2010;7:24.CrossRefPubMedPubMedCentral Young AM, Havens JR, Leukefeld CG. Route of administration for illicit prescription opioids: a comparison of rural and urban drug users. Harm Reduct J. 2010;7:24.CrossRefPubMedPubMedCentral
23.
go back to reference Havens JR, Oser CB, Leukefeld CG, Webster JM, Martin SS, O’Connell DJ, et al. Differences in prevalence of prescription opiate misuse among rural and urban probationers. Am J Drug Alcohol Abuse. 2007;33(2):309–17.CrossRefPubMed Havens JR, Oser CB, Leukefeld CG, Webster JM, Martin SS, O’Connell DJ, et al. Differences in prevalence of prescription opiate misuse among rural and urban probationers. Am J Drug Alcohol Abuse. 2007;33(2):309–17.CrossRefPubMed
25.
go back to reference Faul M, Dailey MW, Sugerman DE, Sasser SM, Levy B, Paulozzi LJ. Disparity in naloxone administration by emergency medical service providers and the burden of drug overdose in US rural communities. Am J Public Health. 2015;105(Suppl 3):e26–32.CrossRefPubMedPubMedCentral Faul M, Dailey MW, Sugerman DE, Sasser SM, Levy B, Paulozzi LJ. Disparity in naloxone administration by emergency medical service providers and the burden of drug overdose in US rural communities. Am J Public Health. 2015;105(Suppl 3):e26–32.CrossRefPubMedPubMedCentral
26.
go back to reference Meit M HM, Tanenbaum E, Hoffmann T. Appalachian diseases of despair. In: Report for the Appalachian Regional Commission. The Walsh Center for Rural Health Analysis National Opinion Research Center (NORC) at the University of Chicago, editor. 2017. Meit M HM, Tanenbaum E, Hoffmann T. Appalachian diseases of despair. In: Report for the Appalachian Regional Commission. The Walsh Center for Rural Health Analysis National Opinion Research Center (NORC) at the University of Chicago, editor. 2017.
27.
go back to reference Cicero TJ, Surratt H, Inciardi JA, Munoz A. Relationship between therapeutic use and abuse of opioid analgesics in rural, suburban, and urban locations in the United States. Pharmacoepidemiol Drug Saf. 2007;16(8):827–40.CrossRefPubMed Cicero TJ, Surratt H, Inciardi JA, Munoz A. Relationship between therapeutic use and abuse of opioid analgesics in rural, suburban, and urban locations in the United States. Pharmacoepidemiol Drug Saf. 2007;16(8):827–40.CrossRefPubMed
28.
go back to reference Havens JR, Young AM, Havens CE. Nonmedical prescription drug use in a nationally representative sample of adolescents: evidence of greater use among rural adolescents. Arch Pediatr Adolesc Med. 2011;165(3):250–5.CrossRefPubMed Havens JR, Young AM, Havens CE. Nonmedical prescription drug use in a nationally representative sample of adolescents: evidence of greater use among rural adolescents. Arch Pediatr Adolesc Med. 2011;165(3):250–5.CrossRefPubMed
29.
go back to reference A comparison of rural and urban substance abuse treatment admissions. In: Center for Behavioral Health Statistics and Quality SAaMHSA, editor. Rockville, MD, 2012. A comparison of rural and urban substance abuse treatment admissions. In: Center for Behavioral Health Statistics and Quality SAaMHSA, editor. Rockville, MD, 2012.
30.
go back to reference Disproportionately high rates of substance abuse in Appalachia [press release]. Appalachian Regional Commission (ARC) Study, 2008. Disproportionately high rates of substance abuse in Appalachia [press release]. Appalachian Regional Commission (ARC) Study, 2008.
31.
go back to reference Centers for Disease C, Prevention. Vital signs: overdoses of prescription opioid pain relievers—United States, 1999–2008. MMWR Morb Mortal Wkly Rep. 2011;60(43):1487–92. Centers for Disease C, Prevention. Vital signs: overdoses of prescription opioid pain relievers—United States, 1999–2008. MMWR Morb Mortal Wkly Rep. 2011;60(43):1487–92.
33.
go back to reference Paulozzi LJ, Mack KA, Hockenberry JM. Variation among states in prescribing of opioid pain relievers and benzodiazepines—United States, 2012. J Saf Res. 2014;51:125–9.CrossRef Paulozzi LJ, Mack KA, Hockenberry JM. Variation among states in prescribing of opioid pain relievers and benzodiazepines—United States, 2012. J Saf Res. 2014;51:125–9.CrossRef
34.
go back to reference Health disparities in Appalachia. In: Report for the Appalachian Regional Commission (ARC)., PDA, Inc., The Cecil G. Sheps Center for Health Services Research, Appalachian Regional Commission, editors. 2017. Health disparities in Appalachia. In: Report for the Appalachian Regional Commission (ARC)., PDA, Inc., The Cecil G. Sheps Center for Health Services Research, Appalachian Regional Commission, editors. 2017.
35.
go back to reference Van Handel MM, Rose CE, Hallisey EJ, Kolling JL, Zibbell JE, Lewis B, et al. County-level vulnerability assessment for rapid dissemination of HIV or HCV infections among persons who inject drugs, United States. J Acquir Immune Defic Syndr. 2016;73(3):323–31.CrossRefPubMedPubMedCentral Van Handel MM, Rose CE, Hallisey EJ, Kolling JL, Zibbell JE, Lewis B, et al. County-level vulnerability assessment for rapid dissemination of HIV or HCV infections among persons who inject drugs, United States. J Acquir Immune Defic Syndr. 2016;73(3):323–31.CrossRefPubMedPubMedCentral
36.
go back to reference Bluthenthal RN, Wenger L, Chu D, Bourgois P, Kral AH. Drug use generations and patterns of injection drug use: birth cohort differences among people who inject drugs in Los Angeles and San Francisco, California. Drug Alcohol Depend. 2017;175:210–8.CrossRefPubMedPubMedCentral Bluthenthal RN, Wenger L, Chu D, Bourgois P, Kral AH. Drug use generations and patterns of injection drug use: birth cohort differences among people who inject drugs in Los Angeles and San Francisco, California. Drug Alcohol Depend. 2017;175:210–8.CrossRefPubMedPubMedCentral
37.
go back to reference Jones CM, Christensen A, Gladden RM. Increases in prescription opioid injection abuse among treatment admissions in the United States, 2004-2013. Drug Alcohol Depend. 2017;176:89–95.CrossRefPubMed Jones CM, Christensen A, Gladden RM. Increases in prescription opioid injection abuse among treatment admissions in the United States, 2004-2013. Drug Alcohol Depend. 2017;176:89–95.CrossRefPubMed
38.
go back to reference Valdiserri R, Khalsa J, Dan C, Holmberg S, Zibbell J, Holtzman D, et al. Confronting the emerging epidemic of HCV infection among young injection drug users. Am J Public Health. 2014;104(5):816–21.CrossRefPubMedPubMedCentral Valdiserri R, Khalsa J, Dan C, Holmberg S, Zibbell J, Holtzman D, et al. Confronting the emerging epidemic of HCV infection among young injection drug users. Am J Public Health. 2014;104(5):816–21.CrossRefPubMedPubMedCentral
39.
go back to reference Jordan AE, Jarlais DD, Hagan H. Prescription opioid misuse and its relation to injection drug use and hepatitis C virus infection: protocol for a systematic review and meta-analysis. Syst Rev. 2014;3:95.CrossRefPubMedPubMedCentral Jordan AE, Jarlais DD, Hagan H. Prescription opioid misuse and its relation to injection drug use and hepatitis C virus infection: protocol for a systematic review and meta-analysis. Syst Rev. 2014;3:95.CrossRefPubMedPubMedCentral
40.
go back to reference Compton WM, Jones CM, Baldwin GT. Relationship between nonmedical prescription-opioid use and heroin use. N Engl J Med. 2016;374(2):154–63.CrossRefPubMed Compton WM, Jones CM, Baldwin GT. Relationship between nonmedical prescription-opioid use and heroin use. N Engl J Med. 2016;374(2):154–63.CrossRefPubMed
41.
go back to reference Prescription opioids and heroin. In: Report from the National Institute on Drug Abuse (NIDA), editor. Updated 2018. Prescription opioids and heroin. In: Report from the National Institute on Drug Abuse (NIDA), editor. Updated 2018.
42.
go back to reference Muhuri P GJ, Davies M. Associations of nonmedical pain reliever use and initiation of heroin use in the United States. In: Center for Behavioral Health Statistics and Quality Substance Abuse and Mental Health Services Administration (SAaMHSA), editor. Rockville, MD, 2013. Muhuri P GJ, Davies M. Associations of nonmedical pain reliever use and initiation of heroin use in the United States. In: Center for Behavioral Health Statistics and Quality Substance Abuse and Mental Health Services Administration (SAaMHSA), editor. Rockville, MD, 2013.
43.
go back to reference Jones CM, Logan J, Gladden RM, Bohm MK. Vital signs: demographic and substance use trends among heroin users—United States, 2002-2013. MMWR Morb Mortal Wkly Rep. 2015;64(26):719–25.PubMedPubMedCentral Jones CM, Logan J, Gladden RM, Bohm MK. Vital signs: demographic and substance use trends among heroin users—United States, 2002-2013. MMWR Morb Mortal Wkly Rep. 2015;64(26):719–25.PubMedPubMedCentral
44.
go back to reference Jones CM. Heroin use and heroin use risk behaviors among nonmedical users of prescription opioid pain relievers—United States, 2002-2004 and 2008-2010. Drug Alcohol Depend. 2013;132(1–2):95–100.CrossRefPubMed Jones CM. Heroin use and heroin use risk behaviors among nonmedical users of prescription opioid pain relievers—United States, 2002-2004 and 2008-2010. Drug Alcohol Depend. 2013;132(1–2):95–100.CrossRefPubMed
45.
go back to reference Boodram B, Mackesy-Amiti ME, Latkin C. The role of social networks and geography on risky injection behaviors of young persons who inject drugs. Drug Alcohol Depend. 2015;154:229–35.CrossRefPubMedPubMedCentral Boodram B, Mackesy-Amiti ME, Latkin C. The role of social networks and geography on risky injection behaviors of young persons who inject drugs. Drug Alcohol Depend. 2015;154:229–35.CrossRefPubMedPubMedCentral
46.
go back to reference Havens JR, Walker R, Leukefeld CG. Prevalence of opioid analgesic injection among rural nonmedical opioid analgesic users. Drug Alcohol Depend. 2007;87(1):98–102.CrossRefPubMed Havens JR, Walker R, Leukefeld CG. Prevalence of opioid analgesic injection among rural nonmedical opioid analgesic users. Drug Alcohol Depend. 2007;87(1):98–102.CrossRefPubMed
47.
48.
go back to reference Werb D, Buxton J, Shoveller J, Richardson C, Rowell G, Wood E. Interventions to prevent the initiation of injection drug use: a systematic review. Drug Alcohol Depend. 2013;133(2):669–76.CrossRefPubMed Werb D, Buxton J, Shoveller J, Richardson C, Rowell G, Wood E. Interventions to prevent the initiation of injection drug use: a systematic review. Drug Alcohol Depend. 2013;133(2):669–76.CrossRefPubMed
49.
go back to reference Grebely J, Oser M, Taylor LE, Dore GJ. Breaking down the barriers to hepatitis C virus (HCV) treatment among individuals with HCV/HIV coinfection: action required at the system, provider, and patient levels. J Infect Dis. 2013;207(Suppl 1):S19–25.CrossRefPubMedPubMedCentral Grebely J, Oser M, Taylor LE, Dore GJ. Breaking down the barriers to hepatitis C virus (HCV) treatment among individuals with HCV/HIV coinfection: action required at the system, provider, and patient levels. J Infect Dis. 2013;207(Suppl 1):S19–25.CrossRefPubMedPubMedCentral
50.
go back to reference Havens JR, Lofwall MR, Frost SD, Oser CB, Leukefeld CG, Crosby RA. Individual and network factors associated with prevalent hepatitis C infection among rural Appalachian injection drug users. Am J Public Health. 2013;103(1):e44–52.CrossRefPubMedPubMedCentral Havens JR, Lofwall MR, Frost SD, Oser CB, Leukefeld CG, Crosby RA. Individual and network factors associated with prevalent hepatitis C infection among rural Appalachian injection drug users. Am J Public Health. 2013;103(1):e44–52.CrossRefPubMedPubMedCentral
51.
52.
go back to reference Young AM, Havens JR. Transition from first illicit drug use to first injection drug use among rural Appalachian drug users: a cross-sectional comparison and retrospective survival analysis. Addiction. 2012;107(3):587–96.CrossRefPubMed Young AM, Havens JR. Transition from first illicit drug use to first injection drug use among rural Appalachian drug users: a cross-sectional comparison and retrospective survival analysis. Addiction. 2012;107(3):587–96.CrossRefPubMed
53.
go back to reference Staton-Tindall M, Webster JM, Oser CB, Havens JR, Leukefeld CG. Drug use, hepatitis C, and service availability: perspectives of incarcerated rural women. Soc Work Public Health. 2015;30(4):385–96.CrossRefPubMedPubMedCentral Staton-Tindall M, Webster JM, Oser CB, Havens JR, Leukefeld CG. Drug use, hepatitis C, and service availability: perspectives of incarcerated rural women. Soc Work Public Health. 2015;30(4):385–96.CrossRefPubMedPubMedCentral
54.
go back to reference Zibbell JE, Iqbal K, Patel RC, Suryaprasad A, Sanders KJ, Moore-Moravian L, et al. Increases in hepatitis C virus infection related to injection drug use among persons aged </=30 years—Kentucky, Tennessee, Virginia, and West Virginia, 2006-2012. MMWR Morb Mortal Wkly Rep. 2015;64(17):453–8.PubMedPubMedCentral Zibbell JE, Iqbal K, Patel RC, Suryaprasad A, Sanders KJ, Moore-Moravian L, et al. Increases in hepatitis C virus infection related to injection drug use among persons aged </=30 years—Kentucky, Tennessee, Virginia, and West Virginia, 2006-2012. MMWR Morb Mortal Wkly Rep. 2015;64(17):453–8.PubMedPubMedCentral
55.
go back to reference Denniston MM, Jiles RB, Drobeniuc J, Klevens RM, Ward JW, McQuillan GM, et al. Chronic hepatitis C virus infection in the United States, National Health and Nutrition Examination Survey 2003 to 2010. Ann Intern Med. 2014;160(5):293–300.CrossRefPubMedPubMedCentral Denniston MM, Jiles RB, Drobeniuc J, Klevens RM, Ward JW, McQuillan GM, et al. Chronic hepatitis C virus infection in the United States, National Health and Nutrition Examination Survey 2003 to 2010. Ann Intern Med. 2014;160(5):293–300.CrossRefPubMedPubMedCentral
56.
go back to reference Patrick SW, Bauer AM, Warren MD, Jones TF, Wester C. Hepatitis C virus infection among women giving birth—Tennessee and United States, 2009-2014. MMWR Morb Mortal Wkly Rep. 2017;66(18):470–3.CrossRefPubMedPubMedCentral Patrick SW, Bauer AM, Warren MD, Jones TF, Wester C. Hepatitis C virus infection among women giving birth—Tennessee and United States, 2009-2014. MMWR Morb Mortal Wkly Rep. 2017;66(18):470–3.CrossRefPubMedPubMedCentral
57.
go back to reference Fleischauer AT, Ruhl L, Rhea S, Barnes E. Hospitalizations for endocarditis and associated health care costs among persons with diagnosed drug dependence—North Carolina, 2010-2015. MMWR Morb Mortal Wkly Rep. 2017;66(22):569–73.CrossRefPubMedPubMedCentral Fleischauer AT, Ruhl L, Rhea S, Barnes E. Hospitalizations for endocarditis and associated health care costs among persons with diagnosed drug dependence—North Carolina, 2010-2015. MMWR Morb Mortal Wkly Rep. 2017;66(22):569–73.CrossRefPubMedPubMedCentral
59.
go back to reference Hall HI, Li J, McKenna MT. HIV in predominantly rural areas of the United States. J Rural Health. 2005;21(3):245–53.CrossRefPubMed Hall HI, Li J, McKenna MT. HIV in predominantly rural areas of the United States. J Rural Health. 2005;21(3):245–53.CrossRefPubMed
60.
go back to reference Conrad C, Bradley HM, Broz D, Buddha S, Chapman EL, Galang RR, et al. Community outbreak of HIV infection linked to injection drug use of oxymorphone—Indiana, 2015. MMWR Morb Mortal Wkly Rep. 2015;64(16):443–4.PubMedPubMedCentral Conrad C, Bradley HM, Broz D, Buddha S, Chapman EL, Galang RR, et al. Community outbreak of HIV infection linked to injection drug use of oxymorphone—Indiana, 2015. MMWR Morb Mortal Wkly Rep. 2015;64(16):443–4.PubMedPubMedCentral
61.
go back to reference Peters PJ, Pontones P, Hoover KW, Patel MR, Galang RR, Shields J, et al. HIV infection linked to injection use of oxymorphone in Indiana, 2014-2015. N Engl J Med. 2016;375(3):229–39.CrossRefPubMed Peters PJ, Pontones P, Hoover KW, Patel MR, Galang RR, Shields J, et al. HIV infection linked to injection use of oxymorphone in Indiana, 2014-2015. N Engl J Med. 2016;375(3):229–39.CrossRefPubMed
62.
go back to reference Morano JP, Zelenev A, Lombard A, Marcus R, Gibson BA, Altice FL. Strategies for hepatitis C testing and linkage to care for vulnerable populations: point-of-care and standard HCV testing in a mobile medical clinic. J Community Health. 2014;39(5):922–34.CrossRefPubMed Morano JP, Zelenev A, Lombard A, Marcus R, Gibson BA, Altice FL. Strategies for hepatitis C testing and linkage to care for vulnerable populations: point-of-care and standard HCV testing in a mobile medical clinic. J Community Health. 2014;39(5):922–34.CrossRefPubMed
63.
go back to reference Young AM, Jonas AB, Havens JR. Social networks and HCV viraemia in anti-HCV-positive rural drug users. Epidemiol Infect. 2013;141(2):402–11.CrossRefPubMed Young AM, Jonas AB, Havens JR. Social networks and HCV viraemia in anti-HCV-positive rural drug users. Epidemiol Infect. 2013;141(2):402–11.CrossRefPubMed
64.
go back to reference Aspinall EJ, Nambiar D, Goldberg DJ, Hickman M, Weir A, Van Velzen E, et al. Are needle and syringe programmes associated with a reduction in HIV transmission among people who inject drugs: a systematic review and meta-analysis. Int J Epidemiol. 2014;43(1):235–48.CrossRefPubMed Aspinall EJ, Nambiar D, Goldberg DJ, Hickman M, Weir A, Van Velzen E, et al. Are needle and syringe programmes associated with a reduction in HIV transmission among people who inject drugs: a systematic review and meta-analysis. Int J Epidemiol. 2014;43(1):235–48.CrossRefPubMed
65.
go back to reference McCormack S, Dunn DT, Desai M, Dolling DI, Gafos M, Gilson R, et al. Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial. Lancet. 2016;387(10013):53–60.CrossRefPubMedPubMedCentral McCormack S, Dunn DT, Desai M, Dolling DI, Gafos M, Gilson R, et al. Pre-exposure prophylaxis to prevent the acquisition of HIV-1 infection (PROUD): effectiveness results from the pilot phase of a pragmatic open-label randomised trial. Lancet. 2016;387(10013):53–60.CrossRefPubMedPubMedCentral
66.
go back to reference Molina JM, Capitant C, Spire B, Pialoux G, Cotte L, Charreau I, et al. On-demand preexposure prophylaxis in men at high risk for HIV-1 infection. N Engl J Med. 2015;373(23):2237–46.CrossRefPubMed Molina JM, Capitant C, Spire B, Pialoux G, Cotte L, Charreau I, et al. On-demand preexposure prophylaxis in men at high risk for HIV-1 infection. N Engl J Med. 2015;373(23):2237–46.CrossRefPubMed
67.
go back to reference Marrazzo JM, del Rio C, Holtgrave DR, Cohen MS, Kalichman SC, Mayer KH, et al. HIV prevention in clinical care settings: 2014 recommendations of the International Antiviral Society-USA Panel. JAMA. 2014;312(4):390–409.CrossRefPubMed Marrazzo JM, del Rio C, Holtgrave DR, Cohen MS, Kalichman SC, Mayer KH, et al. HIV prevention in clinical care settings: 2014 recommendations of the International Antiviral Society-USA Panel. JAMA. 2014;312(4):390–409.CrossRefPubMed
68.
go back to reference Gountas I, Sypsa V, Anagnostou O, Martin N, Vickerman P, Kafetzopoulos E, et al. Treatment and primary prevention in people who inject drugs for chronic hepatitis C infection: is elimination possible in a high-prevalence setting? Addiction. 2017;112(7):1290–9.CrossRefPubMedPubMedCentral Gountas I, Sypsa V, Anagnostou O, Martin N, Vickerman P, Kafetzopoulos E, et al. Treatment and primary prevention in people who inject drugs for chronic hepatitis C infection: is elimination possible in a high-prevalence setting? Addiction. 2017;112(7):1290–9.CrossRefPubMedPubMedCentral
69.
go back to reference Zelenev A, Li J, Mazhnaya A, Basu S, Altice FL. Hepatitis C virus treatment as prevention in an extended network of people who inject drugs in the USA: a modelling study. Lancet Infect Dis. 2017;18(2):215–24.CrossRefPubMed Zelenev A, Li J, Mazhnaya A, Basu S, Altice FL. Hepatitis C virus treatment as prevention in an extended network of people who inject drugs in the USA: a modelling study. Lancet Infect Dis. 2017;18(2):215–24.CrossRefPubMed
70.
go back to reference Rodger AJ, Cambiano V, Bruun T, Vernazza P, Collins S, van Lunzen J, et al. Sexual activity without condoms and risk of HIV transmission in serodifferent couples when the HIV-positive partner is using suppressive antiretroviral therapy. JAMA. 2016;316(2):171–81.CrossRefPubMed Rodger AJ, Cambiano V, Bruun T, Vernazza P, Collins S, van Lunzen J, et al. Sexual activity without condoms and risk of HIV transmission in serodifferent couples when the HIV-positive partner is using suppressive antiretroviral therapy. JAMA. 2016;316(2):171–81.CrossRefPubMed
71.
go back to reference Friedmann PD, Lemon SC, Stein MD, Etheridge RM, D'Aunno TA. Linkage to medical services in the drug abuse treatment outcome study. Med Care. 2001;39(3):284–95.CrossRefPubMed Friedmann PD, Lemon SC, Stein MD, Etheridge RM, D'Aunno TA. Linkage to medical services in the drug abuse treatment outcome study. Med Care. 2001;39(3):284–95.CrossRefPubMed
72.
go back to reference Bruneau J, Zang G, Abrahamowicz M, Jutras-Aswad D, Daniel M, Roy E. Sustained drug use changes after hepatitis C screening and counseling among recently infected persons who inject drugs: a longitudinal study. Clin Infect Dis. 2014;58(6):755–61.CrossRefPubMed Bruneau J, Zang G, Abrahamowicz M, Jutras-Aswad D, Daniel M, Roy E. Sustained drug use changes after hepatitis C screening and counseling among recently infected persons who inject drugs: a longitudinal study. Clin Infect Dis. 2014;58(6):755–61.CrossRefPubMed
Metadata
Title
HIV/HCV Co-infection: Burden of Disease and Care Strategies in Appalachia
Authors
Jonathan P. Moorman
Matthew R. Krolikowski
Stephanie M. Mathis
Robert P. Pack
Publication date
01-08-2018
Publisher
Springer US
Published in
Current HIV/AIDS Reports / Issue 4/2018
Print ISSN: 1548-3568
Electronic ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-018-0404-1

Other articles of this Issue 4/2018

Current HIV/AIDS Reports 4/2018 Go to the issue

The Global Epidemic (SH Vermund, Section Editor)

Federal Response to the Opioid Crisis

HIV and Technology (J Simoni and K Horvath, Section Editors)

eHealth and Prevention of Mother-to-Child Transmission of HIV

HIV and Technology (J Simoni and K Horvath, Section Editors)

eHealth to Enhance Treatment Adherence Among Youth Living with HIV

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.