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Current HIV/AIDS Reports
Published in: Current HIV/AIDS Reports 4/2016

01-08-2016 | Complications of Antiretroviral Therapy (G McComsey, Section Editor)

Lipid Abnormalities and Inflammation in HIV Inflection

Authors: Nicholas T. Funderburg, Nehal N. Mehta

Published in: Current HIV/AIDS Reports | Issue 4/2016

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Abstract

Infection with the human immunodeficiency virus (HIV), and subsequent treatment with antiretroviral therapy (ART), is often associated with perturbations in lipid profiles. Furthermore, persistent inflammation, in spite of suppression of viral replication by ART, likely contributes to modifications in lipid composition and function, exacerbating risk for development of cardiovascular disease (CVD). Increased levels of several pro-inflammatory lipid species, including oxidized low-density lipoprotein (LDL) and high-density lipoprotein (HDL), have been measured in HIV-infected persons and are associated with markers of immune activation. The mechanisms linked to this bidirectional relationship in which inflammation increases lipid levels and promotes their modification, and these modified lipid species perpetuate inflammatory processes, require further investigation. Treatment with statins and other lifestyle modifications, including improvement in dietary intake and exercise, are critical to reducing CVD risk. Well-designed clinical trials that take into account the complex relationships among lipids and inflammation within persons infected with HIV need to be considered.
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Metadata
Title
Lipid Abnormalities and Inflammation in HIV Inflection
Authors
Nicholas T. Funderburg
Nehal N. Mehta
Publication date
01-08-2016
Publisher
Springer US
Published in
Current HIV/AIDS Reports / Issue 4/2016
Print ISSN: 1548-3568
Electronic ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-016-0321-0

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