Skip to main content
Top
Published in: Current HIV/AIDS Reports 1/2015

01-03-2015 | Invited Commentary

Adherence to HIV Care After Pregnancy Among Women in Sub-Saharan Africa: Falling Off the Cliff of the Treatment Cascade

Authors: Christina Psaros, Jocelyn E. Remmert, David R. Bangsberg, Steven A. Safren, Jennifer A. Smit

Published in: Current HIV/AIDS Reports | Issue 1/2015

Login to get access

Abstract

Increased access to testing and treatment means HIV can be managed as a chronic illness, though successful management requires continued engagement with the health care system. Most of the global HIV burden is in sub-Saharan Africa where rates of new infections are consistently higher in women versus men. Pregnancy is often the point at which an HIV diagnosis is made. While preventing mother to child transmission (PMTCT) interventions significantly reduce the rate of vertical transmission of HIV, women must administer ARVs to their infants, adhere to breastfeeding recommendations, and test their infants for HIV after childbirth. Some women will be expected to remain on the ARVs initiated during pregnancy, while others are expected to engage in routine testing so treatment can be reinitiated when appropriate. The postpartum period presents many barriers to sustained treatment adherence and engagement in care. While some studies have examined adherence to postpartum PMTCT guidelines, few have focused on continued engagement in care by the mother, and very few examine adherence beyond the 6-week postpartum visit. Here, we attempt to identify gaps in the research literature and make recommendations on how to address barriers to ongoing postpartum HIV care.
Literature
1.
go back to reference Gardner EM, McLees MP, Steiner JF, Del Rio C, Burman WJ. The spectrum of engagement in HIV care and its relevance to test-and-treat strategies for prevention of HIV infection. Clin Infect Dis. 2011;52:793–800.CrossRefPubMedCentralPubMed Gardner EM, McLees MP, Steiner JF, Del Rio C, Burman WJ. The spectrum of engagement in HIV care and its relevance to test-and-treat strategies for prevention of HIV infection. Clin Infect Dis. 2011;52:793–800.CrossRefPubMedCentralPubMed
3.
go back to reference Gouws E, Stanecki KA, Lyerla R, Ghys PD. The epidemiology of HIV infection among young people aged 15–24 years in southern Africa. AIDS. 2008;22 Suppl 4:S5–16.CrossRefPubMed Gouws E, Stanecki KA, Lyerla R, Ghys PD. The epidemiology of HIV infection among young people aged 15–24 years in southern Africa. AIDS. 2008;22 Suppl 4:S5–16.CrossRefPubMed
4.•
go back to reference Shisana O, Rehle T, Simbayi L, Zuma K, Jooste S, Zungu N, et al. South African National HIV Prevalence, Incidence, and Behaviour Survey, 2012 [Internet]. 2014 [cited 2014 Apr 23]. Available from: http://www.hsrc.ac.za/uploads/pageContent/4565/SABSSM%20IV%20LEO%20final.pdf. Current HIV prevalence rates in South Africa broken down by individual province, age, sex, circumcision status and other information around HIV status including awareness of status and testing and condom use; survey conducted and published by the South African Human Science and Research Council. Shisana O, Rehle T, Simbayi L, Zuma K, Jooste S, Zungu N, et al. South African National HIV Prevalence, Incidence, and Behaviour Survey, 2012 [Internet]. 2014 [cited 2014 Apr 23]. Available from: http://​www.​hsrc.​ac.​za/​uploads/​pageContent/​4565/​SABSSM%20​IV%20​LEO%20​final.​pdf. Current HIV prevalence rates in South Africa broken down by individual province, age, sex, circumcision status and other information around HIV status including awareness of status and testing and condom use; survey conducted and published by the South African Human Science and Research Council.
5.
go back to reference Technau K-G, Kalk E, Coovadia A, Black V, Pickerill S, Mellins CA, et al. Timing of maternal HIV testing and uptake of prevention of mother-to-child transmission interventions among women and their infected infants in Johannesburg, South Africa. J Acquir Immune Defic Syndr. 2014;65:e170–8.CrossRefPubMed Technau K-G, Kalk E, Coovadia A, Black V, Pickerill S, Mellins CA, et al. Timing of maternal HIV testing and uptake of prevention of mother-to-child transmission interventions among women and their infected infants in Johannesburg, South Africa. J Acquir Immune Defic Syndr. 2014;65:e170–8.CrossRefPubMed
8.
go back to reference Goga A, Dinh T, Jackson D, for the SAPMTCTE study group. Evaluation of the Effectiveness of the National Prevention of Mother-to-Child Transmission (PMTCT) Programme Measured at 6 Weeks Postpartum in South Africa, 2010. South African Medical Research Councitl, National Department of Health of Health of South Africa and PEPFAR/US Centers for Disease Control and Prevention; 2012. Goga A, Dinh T, Jackson D, for the SAPMTCTE study group. Evaluation of the Effectiveness of the National Prevention of Mother-to-Child Transmission (PMTCT) Programme Measured at 6 Weeks Postpartum in South Africa, 2010. South African Medical Research Councitl, National Department of Health of Health of South Africa and PEPFAR/US Centers for Disease Control and Prevention; 2012.
12.
go back to reference Oladokun RE, Brown B, Osinusi K. Loss to follow-up rate, reasons and associated risk factors among mother-infant pairs in a Prevention of Mother-to-Child Transmission Programme (PMTCT) in Nigeria: a case control study. Nigerian J Paediatr. 2006;33:79–84. Oladokun RE, Brown B, Osinusi K. Loss to follow-up rate, reasons and associated risk factors among mother-infant pairs in a Prevention of Mother-to-Child Transmission Programme (PMTCT) in Nigeria: a case control study. Nigerian J Paediatr. 2006;33:79–84.
13.
go back to reference Psaros C. Contextual risk among pregnant, second generation young women in South Africa. Paris, France; 2013. Psaros C. Contextual risk among pregnant, second generation young women in South Africa. Paris, France; 2013.
14.
go back to reference Kalichman SC, Simbayi LC, Jooste S, Toefy Y, Cain D, Cherry C, et al. Development of a brief scale to measure AIDS-related stigma in South Africa. AIDS Behav. 2005;9:135–43.CrossRefPubMed Kalichman SC, Simbayi LC, Jooste S, Toefy Y, Cain D, Cherry C, et al. Development of a brief scale to measure AIDS-related stigma in South Africa. AIDS Behav. 2005;9:135–43.CrossRefPubMed
15.
16.
go back to reference Wolfe WR, Weiser SD, Leiter K, Steward WT, Percy-de Korte F, Phaladze N, et al. The impact of universal access to antiretroviral therapy on HIV stigma in Botswana. Am J Public Health. 2008;98:1865–71.CrossRefPubMedCentralPubMed Wolfe WR, Weiser SD, Leiter K, Steward WT, Percy-de Korte F, Phaladze N, et al. The impact of universal access to antiretroviral therapy on HIV stigma in Botswana. Am J Public Health. 2008;98:1865–71.CrossRefPubMedCentralPubMed
17.
go back to reference Chinkonde JR, Sundby J, Martinson F. The prevention of mother-to-child HIV transmission programme in Lilongwe, Malawi: why do so many women drop out. Reprod Health Matter. 2009;17:143–51.CrossRef Chinkonde JR, Sundby J, Martinson F. The prevention of mother-to-child HIV transmission programme in Lilongwe, Malawi: why do so many women drop out. Reprod Health Matter. 2009;17:143–51.CrossRef
18.••
go back to reference Nachega JB, Uthman OA, Anderson J, Peltzer K, Wampold S, Cotton MF, et al. Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysis. AIDS. 2012;26:2039–52. Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysis.CrossRefPubMed Nachega JB, Uthman OA, Anderson J, Peltzer K, Wampold S, Cotton MF, et al. Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysis. AIDS. 2012;26:2039–52. Adherence to antiretroviral therapy during and after pregnancy in low-income, middle-income, and high-income countries: a systematic review and meta-analysis.CrossRefPubMed
19.
go back to reference Abrams EJ, Myer L, Rosenfield A, El-Sadr WM. Prevention of mother-to-child transmission services as a gateway to family-based human immunodeficiency virus care and treatment in resource-limited settings: rationale and international experiences. Am J Obstet Gynecol. 2007;197:S101–6.CrossRefPubMed Abrams EJ, Myer L, Rosenfield A, El-Sadr WM. Prevention of mother-to-child transmission services as a gateway to family-based human immunodeficiency virus care and treatment in resource-limited settings: rationale and international experiences. Am J Obstet Gynecol. 2007;197:S101–6.CrossRefPubMed
20.
go back to reference Bwirire LD, Fitzgerald M, Zachariah R, Chikafa V, Massaquoi M, Moens M, et al. Reasons for loss to follow-up among mothers registered in a prevention-of-mother-to-child transmission program in rural Malawi. Trans R Soc Trop Med Hyg. 2008;102:1195–200.CrossRefPubMed Bwirire LD, Fitzgerald M, Zachariah R, Chikafa V, Massaquoi M, Moens M, et al. Reasons for loss to follow-up among mothers registered in a prevention-of-mother-to-child transmission program in rural Malawi. Trans R Soc Trop Med Hyg. 2008;102:1195–200.CrossRefPubMed
21.
go back to reference Lubega M, Musenze IA, Joshua G, Dhafa G, Badaza R, Bakwesegha CJ, et al. Sex inequality, high transport costs, and exposed clinic location: reasons for loss to follow-up of clients under prevention of mother-to-child HIV transmission in eastern Uganda—a qualitative study. Patient Prefer Adherence. 2013;7:447–54.CrossRefPubMedCentralPubMed Lubega M, Musenze IA, Joshua G, Dhafa G, Badaza R, Bakwesegha CJ, et al. Sex inequality, high transport costs, and exposed clinic location: reasons for loss to follow-up of clients under prevention of mother-to-child HIV transmission in eastern Uganda—a qualitative study. Patient Prefer Adherence. 2013;7:447–54.CrossRefPubMedCentralPubMed
22.
go back to reference Manzi M, Zachariah R, Teck R, Buhendwa L, Kazima J, Bakali E, et al. High acceptability of voluntary counselling and HIV-testing but unacceptable loss to follow up in a prevention of mother-to-child HIV transmission programme in rural Malawi: scaling-up requires a different way of acting. Trop Med Int Health. 2005;10:1242–50.CrossRefPubMed Manzi M, Zachariah R, Teck R, Buhendwa L, Kazima J, Bakali E, et al. High acceptability of voluntary counselling and HIV-testing but unacceptable loss to follow up in a prevention of mother-to-child HIV transmission programme in rural Malawi: scaling-up requires a different way of acting. Trop Med Int Health. 2005;10:1242–50.CrossRefPubMed
23.
go back to reference Marcos Y, Phelps BR, Bachman G. Community strategies that improve care and retention along the prevention of mother-to-child transmission of HIV cascade: a review. J Int AIDS Soc. 2012;15 Suppl 2:17394.PubMedCentralPubMed Marcos Y, Phelps BR, Bachman G. Community strategies that improve care and retention along the prevention of mother-to-child transmission of HIV cascade: a review. J Int AIDS Soc. 2012;15 Suppl 2:17394.PubMedCentralPubMed
24.
go back to reference Moth IA, Ayayo ABCO, Kaseje DO. Assessment of utilisation of PMTCT services at Nyanza Provincial Hospital, Kenya. SAHARA J. 2005;2:244–50.CrossRefPubMed Moth IA, Ayayo ABCO, Kaseje DO. Assessment of utilisation of PMTCT services at Nyanza Provincial Hospital, Kenya. SAHARA J. 2005;2:244–50.CrossRefPubMed
25.
go back to reference Sherman GG, Jones SA, Coovadia AH, Urban MF, Bolton KD. PMTCT from research to reality—results from a routine service. S Afr Med J. 2004;94:289–92.PubMed Sherman GG, Jones SA, Coovadia AH, Urban MF, Bolton KD. PMTCT from research to reality—results from a routine service. S Afr Med J. 2004;94:289–92.PubMed
26.•
go back to reference Sibanda EL, Weller IVD, Hakim JG, Cowan FM. The magnitude of loss to follow-up of HIV-exposed infants along the prevention of mother-to-child HIV transmission continuum of care: a systematic review and meta-analysis. AIDS. 2013;27:2787–97. The magnitude of loss to follow-up of HIV-exposed infants along the prevention of mother-to-child HIV transmission continuum of care: a systematic review and meta-analysis.CrossRefPubMedCentralPubMed Sibanda EL, Weller IVD, Hakim JG, Cowan FM. The magnitude of loss to follow-up of HIV-exposed infants along the prevention of mother-to-child HIV transmission continuum of care: a systematic review and meta-analysis. AIDS. 2013;27:2787–97. The magnitude of loss to follow-up of HIV-exposed infants along the prevention of mother-to-child HIV transmission continuum of care: a systematic review and meta-analysis.CrossRefPubMedCentralPubMed
27.
go back to reference Stringer EM, Sinkala M, Stringer JS, Mzyece E, Makuka I, Goldenberg RL, et al. Prevention of mother-to-child transmission of HIV in Africa: successes and challenges in scaling-up a nevirapine-based program in Lusaka, Zambia. AIDS. 2003;17:1377–82.CrossRefPubMedCentralPubMed Stringer EM, Sinkala M, Stringer JS, Mzyece E, Makuka I, Goldenberg RL, et al. Prevention of mother-to-child transmission of HIV in Africa: successes and challenges in scaling-up a nevirapine-based program in Lusaka, Zambia. AIDS. 2003;17:1377–82.CrossRefPubMedCentralPubMed
28.
go back to reference Theuring S, Mbezi P, Luvanda H, Jordan-Harder B, Kunz A, Harms G. Male involvement in PMTCT services in Mbeya Region, Tanzania. AIDS Behav. 2009;13 Suppl 1:92–102.CrossRefPubMed Theuring S, Mbezi P, Luvanda H, Jordan-Harder B, Kunz A, Harms G. Male involvement in PMTCT services in Mbeya Region, Tanzania. AIDS Behav. 2009;13 Suppl 1:92–102.CrossRefPubMed
29.
go back to reference Van Lettow M, Bedell R, Landes M, Gawa L, Gatto S, Mayuni I, et al. Uptake and outcomes of a prevention-of mother-to-child transmission (PMTCT) program in Zomba district, Malawi. BMC Public Health. 2011;11:426.CrossRefPubMedCentralPubMed Van Lettow M, Bedell R, Landes M, Gawa L, Gatto S, Mayuni I, et al. Uptake and outcomes of a prevention-of mother-to-child transmission (PMTCT) program in Zomba district, Malawi. BMC Public Health. 2011;11:426.CrossRefPubMedCentralPubMed
30.
go back to reference Fowler MG, Lampe MA, Jamieson DJ, Kourtis AP, Rogers MF. Reducing the risk of mother-to-child human immunodeficiency virus transmission: past successes, current progress and challenges, and future directions. Am J Obstet Gynecol. 2007;197:S3–9.CrossRefPubMed Fowler MG, Lampe MA, Jamieson DJ, Kourtis AP, Rogers MF. Reducing the risk of mother-to-child human immunodeficiency virus transmission: past successes, current progress and challenges, and future directions. Am J Obstet Gynecol. 2007;197:S3–9.CrossRefPubMed
31.
32.
go back to reference Mindry D, Maman S, Chirowodza A, Muravha T, van Rooyen H, Coates T. Looking to the future: South African men and women negotiating HIV risk and relationship intimacy. Cult Health Sex. 2011;13:589–602.CrossRefPubMedCentralPubMed Mindry D, Maman S, Chirowodza A, Muravha T, van Rooyen H, Coates T. Looking to the future: South African men and women negotiating HIV risk and relationship intimacy. Cult Health Sex. 2011;13:589–602.CrossRefPubMedCentralPubMed
33.
go back to reference Levy JM. Women’s expectations of treatment and care after an antenatal HIV diagnosis in Lilongwe, Malawi. Reprod Health Matters. 2009;17:152–61.CrossRefPubMed Levy JM. Women’s expectations of treatment and care after an antenatal HIV diagnosis in Lilongwe, Malawi. Reprod Health Matters. 2009;17:152–61.CrossRefPubMed
34.
go back to reference Chetty T, Knight S, Giddy J, Crankshaw TL, Butler LM, Newell M-L. A retrospective study of Human Immunodeficiency Virus transmission, mortality and loss to follow-up among infants in the first 18 months of life in a prevention of mother-to-child transmission programme in an urban hospital in KwaZulu-Natal, South Africa. BMC Pediatr. 2012;12:146.CrossRefPubMedCentralPubMed Chetty T, Knight S, Giddy J, Crankshaw TL, Butler LM, Newell M-L. A retrospective study of Human Immunodeficiency Virus transmission, mortality and loss to follow-up among infants in the first 18 months of life in a prevention of mother-to-child transmission programme in an urban hospital in KwaZulu-Natal, South Africa. BMC Pediatr. 2012;12:146.CrossRefPubMedCentralPubMed
35.
go back to reference Jones SA, Sherman GG, Varga CA. Exploring socio-economic conditions and poor follow-up rates of HIV-exposed infants in Johannesburg. South Africa AIDS Care. 2005;17:466–70.CrossRef Jones SA, Sherman GG, Varga CA. Exploring socio-economic conditions and poor follow-up rates of HIV-exposed infants in Johannesburg. South Africa AIDS Care. 2005;17:466–70.CrossRef
36.
go back to reference Kurewa EN, Kandawasvika GQ, Mhlanga F, Munjoma M, Mapingure MP, Chandiwana P, et al. Realities and challenges of a 5 year follow Up of mother and child pairs on a PMTCT program in Zimbabwe. Open AIDS J. 2011;5:51–8.CrossRefPubMedCentralPubMed Kurewa EN, Kandawasvika GQ, Mhlanga F, Munjoma M, Mapingure MP, Chandiwana P, et al. Realities and challenges of a 5 year follow Up of mother and child pairs on a PMTCT program in Zimbabwe. Open AIDS J. 2011;5:51–8.CrossRefPubMedCentralPubMed
37.
go back to reference Kasenga F, Hurtig A-K, Emmelin M. HIV-positive women’s experiences of a PMTCT programme in rural Malawi. Midwifery. 2010;26:27–37.CrossRefPubMed Kasenga F, Hurtig A-K, Emmelin M. HIV-positive women’s experiences of a PMTCT programme in rural Malawi. Midwifery. 2010;26:27–37.CrossRefPubMed
38.
go back to reference O’Gorman DA, Nyirenda LJ, Theobald SJ. Prevention of mother-to-child transmission of HIV infection: views and perceptions about swallowing nevirapine in rural Lilongwe, Malawi. BMC Public Health. 2010;10:354.CrossRefPubMedCentralPubMed O’Gorman DA, Nyirenda LJ, Theobald SJ. Prevention of mother-to-child transmission of HIV infection: views and perceptions about swallowing nevirapine in rural Lilongwe, Malawi. BMC Public Health. 2010;10:354.CrossRefPubMedCentralPubMed
39.
go back to reference Clouse K, Pettifor A, Shearer K, Maskew M, Bassett J, Larson B, et al. Loss to follow-up before and after delivery among women testing HIV positive during pregnancy in Johannesburg, South Africa. Trop Med Int Health. 2013;18:451–60.CrossRefPubMedCentralPubMed Clouse K, Pettifor A, Shearer K, Maskew M, Bassett J, Larson B, et al. Loss to follow-up before and after delivery among women testing HIV positive during pregnancy in Johannesburg, South Africa. Trop Med Int Health. 2013;18:451–60.CrossRefPubMedCentralPubMed
40.
go back to reference Lambert JS, Avramovic G, Jackson V, Sammon N, Lally S, Campbell FJ. Investigation into the reasons for maternal default from HIV care postpartum: a 3-year retrospective review. AIDS Patient Care STDS. 2014;28:1–3.CrossRefPubMed Lambert JS, Avramovic G, Jackson V, Sammon N, Lally S, Campbell FJ. Investigation into the reasons for maternal default from HIV care postpartum: a 3-year retrospective review. AIDS Patient Care STDS. 2014;28:1–3.CrossRefPubMed
41.
go back to reference Nassali M, Nakanjako D, Kyabayinze D, Beyeza J, Okoth A, Mutyaba T. Access to HIV/AIDS care for mothers and children in sub-Saharan Africa: adherence to the postnatal PMTCT program. AIDS Care. 2009;21:1124–31.CrossRefPubMed Nassali M, Nakanjako D, Kyabayinze D, Beyeza J, Okoth A, Mutyaba T. Access to HIV/AIDS care for mothers and children in sub-Saharan Africa: adherence to the postnatal PMTCT program. AIDS Care. 2009;21:1124–31.CrossRefPubMed
42.
go back to reference Clouse K, Schwartz S, Van Rie A, Bassett J, Yende N, Pettifor A. “What they wanted was to give birth; nothing else”: Barriers to retention in Option B+ HIV care among postpartum women in South Africa. J. Acquir. Immune Defic. Syndr. 2014. Clouse K, Schwartz S, Van Rie A, Bassett J, Yende N, Pettifor A. “What they wanted was to give birth; nothing else”: Barriers to retention in Option B+ HIV care among postpartum women in South Africa. J. Acquir. Immune Defic. Syndr. 2014.
43.
go back to reference Siegel L, El-Sadr W. New Perspectives in HIV Treatment Interruption: The SMART Study. The PRN Notebook. 2006;11. Siegel L, El-Sadr W. New Perspectives in HIV Treatment Interruption: The SMART Study. The PRN Notebook. 2006;11.
44.
go back to reference Oyugi JH, Byakika-Tusiime J, Ragland K, Laeyendecker O, Mugyenyi P, Quinn TC, et al. Treatment interruptions predict resistance in HIV-positive individuals purchasing fixed-dose combination antiretroviral therapy in Kampala. Uganda AIDS. 2007;21:965–71. Oyugi JH, Byakika-Tusiime J, Ragland K, Laeyendecker O, Mugyenyi P, Quinn TC, et al. Treatment interruptions predict resistance in HIV-positive individuals purchasing fixed-dose combination antiretroviral therapy in Kampala. Uganda AIDS. 2007;21:965–71.
45.•
go back to reference Colvin CJ, Konopka S, Chalker JC, Jonas E, Albertini J, Amzel A, et al. A Systematic Review of Health System Barriers and Enablers for Antiretroviral Therapy (ART) for HIV-Infected Pregnant and Postpartum Women. PLoS One [Internet]. 2014 [cited 2014 Oct 21];9. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4193745/. Large review demonstrating that there is still low prioritization of maternal ART and continued dropout along the PMTCT cascade. Key barriers identified include poor communication and coordination within the health system and gaps in provider training. Colvin CJ, Konopka S, Chalker JC, Jonas E, Albertini J, Amzel A, et al. A Systematic Review of Health System Barriers and Enablers for Antiretroviral Therapy (ART) for HIV-Infected Pregnant and Postpartum Women. PLoS One [Internet]. 2014 [cited 2014 Oct 21];9. Available from: http://​www.​ncbi.​nlm.​nih.​gov/​pmc/​articles/​PMC4193745/​. Large review demonstrating that there is still low prioritization of maternal ART and continued dropout along the PMTCT cascade. Key barriers identified include poor communication and coordination within the health system and gaps in provider training.
Metadata
Title
Adherence to HIV Care After Pregnancy Among Women in Sub-Saharan Africa: Falling Off the Cliff of the Treatment Cascade
Authors
Christina Psaros
Jocelyn E. Remmert
David R. Bangsberg
Steven A. Safren
Jennifer A. Smit
Publication date
01-03-2015
Publisher
Springer US
Published in
Current HIV/AIDS Reports / Issue 1/2015
Print ISSN: 1548-3568
Electronic ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-014-0252-6

Other articles of this Issue 1/2015

Current HIV/AIDS Reports 1/2015 Go to the issue

The Science of Prevention (JD Stekler, Section Editor)

Revitalizing Condom-Centered HIV Prevention Strategies

HIV Pathogenesis and Treatment (AL Landay, Section Editor)

Type I Interferon: Understanding Its Role in HIV Pathogenesis and Therapy

HIV Pathogenesis and Treatment (AL Landay, Section Editor)

Bioinformatics and HIV Latency

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.