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Current HIV/AIDS Reports
Published in: Current HIV/AIDS Reports 1/2014

01-03-2014 | HIV Pathogenesis and Treatment (AL Landay, Section Editor)

Inflammatory Co-morbidities in HIV+ Individuals: Learning Lessons from Healthy Ageing

Authors: Anna C. Hearps, Genevieve E. Martin, Reena Rajasuriar, Suzanne M. Crowe

Published in: Current HIV/AIDS Reports | Issue 1/2014

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Abstract

Increased life expectancy due to improved efficacy of cART has uncovered an increased risk of age-related morbidities in HIV+ individuals and catalyzed significant research into mechanisms driving these diseases. HIV infection increases the risk of non-communicable diseases common in the aged, including cardiovascular disease, neurocognitive decline, non-AIDS malignancies, osteoporosis, and frailty. These observations suggest that HIV accelerates immunological ageing, and there are many immunological similarities with the aged, including shortened telomeres, accumulation of senescent T cells and altered monocyte phenotype/function. However, the most critical similarity between HIV+ individuals and the elderly, which most likely underpins the heightened risk of non-communicable diseases, is chronic inflammation and associated immune activation. Here, we review the similarities between HIV+ individuals and the aged regarding the pathogenesis of inflammatory diseases, the current evidence for mechanisms driving these processes and discuss current and potential therapeutic strategies for addressing inflammatory co-morbidity in HIV+ infection.
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Metadata
Title
Inflammatory Co-morbidities in HIV+ Individuals: Learning Lessons from Healthy Ageing
Authors
Anna C. Hearps
Genevieve E. Martin
Reena Rajasuriar
Suzanne M. Crowe
Publication date
01-03-2014
Publisher
Springer US
Published in
Current HIV/AIDS Reports / Issue 1/2014
Print ISSN: 1548-3568
Electronic ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-013-0190-8

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