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Open Access 01-11-2010

Alcohol and HIV Disease Progression: Weighing the Evidence

Authors: Judith A. Hahn, Jeffrey H. Samet

Published in: Current HIV/AIDS Reports | Issue 4/2010

Abstract

Heavy alcohol use is commonplace among HIV-infected individuals; however, the extent that alcohol use adversely impacts HIV disease progression has not been fully elucidated. Fairly strong evidence suggests that heavy alcohol consumption results in behavioral and biological processes that likely increase HIV disease progression, and experimental evidence of the biological effect of heavy alcohol on simian immunodeficiency virus in macaques is quite suggestive. However, several observational studies of the effect of heavy alcohol consumption on HIV progression conducted in the 1990s found no association of heavy alcohol consumption with time to AIDS diagnosis, while some more recent studies showed associations of heavy alcohol consumption with declines of CD4 cell counts and nonsuppression of HIV viral load. We discuss several plausible biological and behavioral mechanisms by which alcohol may cause HIV disease progression, evidence from prospective observational human studies, and suggest future research to further illuminate this important issue.

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Title: Alcohol and HIV Disease Progression: Weighing the Evidence
Authors: Judith A. Hahn
Jeffrey H. Samet
Publication date: 01-11-2010
Publisher: Current Science Inc.
Published in: Current HIV/AIDS Reports / Issue 4/2010
Print ISSN: 1548-3568
Electronic ISSN: 1548-3576
DOI: https://doi.org/10.1007/s11904-010-0060-6

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