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Current HIV/AIDS Reports
Published in: Current HIV/AIDS Reports 1/2010

Open Access 01-02-2010

Where the Wild Things Are: Pathogenesis of SIV Infection in African Nonhuman Primate Hosts

Authors: Ivona Pandrea, Cristian Apetrei

Published in: Current HIV/AIDS Reports | Issue 1/2010

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Abstract

African nonhuman primates that are natural hosts of simian immunodeficiency virus (SIV) are generally spared from disease progression. Pathogenic and nonpathogenic SIV infections share some major features: high viral replication, massive acute depletion of mucosal CD4+ T cells, and partial control of the virus by both adaptive and innate immune responses. A key distinction of natural SIV infections is rapid and active control of immune activation and apoptosis of T cells that contributes to the integrity of mucosal barrier and lack of microbial translocation. This allows partial recovery of CD4+ T cells and preservation of the function of other immune cell subsets. A better understanding of the mechanisms underlying the lack of disease in natural hosts for SIV infection will likely provide important clues as to the therapy of HIV-1 infection.
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Metadata
Title
Where the Wild Things Are: Pathogenesis of SIV Infection in African Nonhuman Primate Hosts
Authors
Ivona Pandrea
Cristian Apetrei
Publication date
01-02-2010
Publisher
Current Science Inc.
Published in
Current HIV/AIDS Reports / Issue 1/2010
Print ISSN: 1548-3568
Electronic ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-009-0034-8

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