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Current Hepatology Reports

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01-12-2020 | Probiotics | Fatty Liver Disease (D Halegoua-DeMarzio, Section Editor)

The Role of Gut Microbiome-Targeted Therapy in Nonalcoholic Fatty Liver Disease

Authors: Chencheng Xie, Dina Halegoua-DeMarzio

Published in: Current Hepatology Reports | Issue 4/2020

Abstract

Purpose of Review

To review the role and progress of microbiome-targeting therapies in nonalcoholic fatty liver disease (NAFLD). This review summarizes recent clinical trials of probiotics, prebiotics, synbiotics, and fecal microbiota transplantation (FMT) and analyzes the potential clinical impact of reverse dysbiosis in NAFLD.

Recent Findings

Though results might be mixed, the recent randomized clinical trials and systemic reviews indicate probiotics, prebiotics, and synbiotics are promising therapies that improve transaminitis and hepatic steatosis. The scarcity of FMT clinical trials limits the power to conclude the direct impact of FMT on NAFLD.

Summary

Given the rapidly growing prevalence of NAFLD and the lack of effective pharmacological intervention, there is an urgent need for the development of novel therapeutic strategies. Despite the advancements in and promising results of gut microbiome (GM) restoring remedies, further studies are needed to assess their beneficial efficacy, safety, and sustainability to develop novel pharmacologic approaches to NAFLD.

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Title: The Role of Gut Microbiome-Targeted Therapy in Nonalcoholic Fatty Liver Disease
Authors: Chencheng Xie
Dina Halegoua-DeMarzio
Publication date: 01-12-2020
Publisher: Springer US
Keywords: Probiotics
Fatty Liver
Respiratory Microbiota
Published in: Current Hepatology Reports / Issue 4/2020
Electronic ISSN: 2195-9595
DOI: https://doi.org/10.1007/s11901-020-00547-5

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

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Image Credits

STEP AAG HeroTeaserCollection image/© Tarek / Generated with AI / Stock.adobe.com, ACC 2024 Pediatric and Congenital Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Pulmonary Vascular Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 Valvular Heart Disease: Year in Review/© 2024 American College of Cardiology, ACC 2024 HF and Cardiomyopathies: Year in Review/© 2024 American College of Cardiology, Woman out walking/© Seventyfour / stock.adobe.com (symbolic image with model), Woman checking smartwatch /© saltdium / stock.adobe.com (symbolic image with model), Cardiac catheterization/© Damian / stock.adobe.com

At a glance: The STEP trials

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Abstract

Purpose of Review

Recent Findings

Summary

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Other articles of this Issue 4/2020

Role of Nucleic Acid Polymers and Entry Inhibitors in Functional Cure Strategies for HBV

Spontaneous Bacterial Peritonitis and Secondary Bacterial Peritonitis—a Comprehensive Review

Diagnosis and Management of Occult Hepatitis B Infection

Current Transplant Criteria for Hepatocellular Carcinoma—Overuse or Underuse

High-Risk Groups for Non-alcoholic Fatty Liver and Non-alcoholic Steatohepatitis Development and Progression

Genomic Landscape of HCC

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