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Current Hepatology Reports
Published in: Current Hepatology Reports 4/2017

01-12-2017 | Fatty Liver Disease (S Harrison and J George, Section Editors)

Managing HCC in NAFLD

Authors: Darren Hiu-Sun Foog, Deborah Kwok, Becky Ching-Yeung Yu, Vincent Wai-Sun Wong

Published in: Current Hepatology Reports | Issue 4/2017

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Abstract

Purpose of Review

We aim to review the epidemiology, risk factors, diagnosis, and treatment of hepatocellular carcinoma (HCC) in patients with non-alcoholic fatty liver disease (NAFLD).

Recent Findings

NAFLD-HCC is increasingly common in Western countries and has become the third leading cause of HCC in the USA. While cirrhosis is the most important risk factor for NAFLD-HCC, one third of such patients are non-cirrhotic. Few cases of NAFLD-HCC are identified by screening, resulting in delayed presentation. Liver resection, transplantation, and local ablative therapy are curative treatments for HCC. Although medical and surgical complications are more common after surgery for NAFLD-HCC because of obesity, the long-term outcome is similar to that for other causes of HCC.

Summary

NAFLD-HCC is expected to become a major cause of morbidity and mortality. Better understanding of the risk factors of NAFLD-HCC and development of prediction tools will help select patients for screening and improve outcomes.
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Metadata
Title
Managing HCC in NAFLD
Authors
Darren Hiu-Sun Foog
Deborah Kwok
Becky Ching-Yeung Yu
Vincent Wai-Sun Wong
Publication date
01-12-2017
Publisher
Springer US
Published in
Current Hepatology Reports / Issue 4/2017
Electronic ISSN: 2195-9595
DOI
https://doi.org/10.1007/s11901-017-0376-4

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