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Published in: Current Hematologic Malignancy Reports 4/2019

01-08-2019 | Acupuncture | Health Economics (N Khera, Section Editor)

Emerging Role of Integrative Medicine in Hematologic Malignancies: a Literature Review and Update on Current Trends in Complementary Medical Practices in Hematologic Cancers

Authors: Onyemaechi N. Okolo, Krisstina Gowin

Published in: Current Hematologic Malignancy Reports | Issue 4/2019

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Abstract

Purpose of Review

This review discusses the emerging role of integrative hematology. It reinforces the growing interest of CAM among patients, and the importance of provider knowledge and participation in discussions with patients about the subject. The main question asked in this review, “Is there evidence for the use of integrative medicine practices in the field of malignant hematology?” is answered by examining current research and providing relevant summaries.

Recent Findings

Data suggests that practices such as meditative movement, exercise, nutrition and supplements and touch therapy can be used for symptom alleviation, preventive measures, and novel treatment development.

Summary

Integrative hematology is a needed part of complete patient care, and it is the role of providers to be knowledgeable and open to ensure patients are engaging in practices that are evidence-informed and safe. More studies are needed in the field in order to make concrete and robust recommendations.
Appendix
Available only for authorised users
Literature
1.
go back to reference Rohan EA, Miller N, Bonner F, Fultz-Butts K, Pratt-Chapman ML, Alfano CM, et al. Comprehensive cancer control: promoting survivor health and wellness. Cancer Causes Control. 2018;29:1277–85.CrossRefPubMed Rohan EA, Miller N, Bonner F, Fultz-Butts K, Pratt-Chapman ML, Alfano CM, et al. Comprehensive cancer control: promoting survivor health and wellness. Cancer Causes Control. 2018;29:1277–85.CrossRefPubMed
2.
go back to reference Qureshi M, Zelinski E, Carlson LE. Cancer and complementary therapies: current trends in survivors’ interest and use. Integr Cancer Ther. 2018;17(3):844–53.CrossRefPubMedPubMedCentral Qureshi M, Zelinski E, Carlson LE. Cancer and complementary therapies: current trends in survivors’ interest and use. Integr Cancer Ther. 2018;17(3):844–53.CrossRefPubMedPubMedCentral
3.
go back to reference • Kline RM, Arora NK, Bradley CJ, Brauer ER, Graves DL, Lunsford NB, et al. Long-term survivorship care after cancer treatment - summary of a 2017 National Cancer Policy Forum workshop. J Natl Cancer Inst. 2018. A study sponsored by the National Cancer Policy Forum of the National Academies of Sciences focusing on long-term survivorship care after treatment, which concluded, among other things, that there are substantial obstacles related to the routine delivery of standardized physical and psychosocial care services to patients and their families.;110:1300 10.CrossRefPubMed • Kline RM, Arora NK, Bradley CJ, Brauer ER, Graves DL, Lunsford NB, et al. Long-term survivorship care after cancer treatment - summary of a 2017 National Cancer Policy Forum workshop. J Natl Cancer Inst. 2018. A study sponsored by the National Cancer Policy Forum of the National Academies of Sciences focusing on long-term survivorship care after treatment, which concluded, among other things, that there are substantial obstacles related to the routine delivery of standardized physical and psychosocial care services to patients and their families.;110:1300 10.CrossRefPubMed
4.
go back to reference •• Witt CM, Balneaves LG, Cardoso MJ, et al. A comprehensive definition for integrative oncology. J Natl Cancer Inst Monogr. 2017;2017(52):lgx012 https://doi.org/10.1093/jncimonographs/lgx012. This paper identified that, although there are generally understood definitions of integrative oncology, there was no agreed upon official definition. By using a mixed-methods approach and an interdisciplinary expert panel, a definition was written and adopted. •• Witt CM, Balneaves LG, Cardoso MJ, et al. A comprehensive definition for integrative oncology. J Natl Cancer Inst Monogr. 2017;2017(52):lgx012 https://​doi.​org/​10.​1093/​jncimonographs/​lgx012. This paper identified that, although there are generally understood definitions of integrative oncology, there was no agreed upon official definition. By using a mixed-methods approach and an interdisciplinary expert panel, a definition was written and adopted.
5.
go back to reference Deng G, Cassileth B. Integrative oncology: an overview. Am Soc Clin Oncol Educ Book. 2014;34:233–42.CrossRef Deng G, Cassileth B. Integrative oncology: an overview. Am Soc Clin Oncol Educ Book. 2014;34:233–42.CrossRef
6.
go back to reference Hack CC, Hüttner NBM, Hackl J, Fasching PA, Beckmann MW. Classification of integrative medicine: overview and significance in oncology. Gynakologe. 2017;50(1):9–14.CrossRef Hack CC, Hüttner NBM, Hackl J, Fasching PA, Beckmann MW. Classification of integrative medicine: overview and significance in oncology. Gynakologe. 2017;50(1):9–14.CrossRef
7.
go back to reference Greenlee H, Balneaves LG, Carlson LE, Cohen M, Deng G, Hershman D, et al. Clinical practice guidelines on the use of integrative therapies as supportive care in patients treated for breast cancer. J Natl Cancer Inst Monogr. 2014;2014(50):346–58.CrossRefPubMedPubMedCentral Greenlee H, Balneaves LG, Carlson LE, Cohen M, Deng G, Hershman D, et al. Clinical practice guidelines on the use of integrative therapies as supportive care in patients treated for breast cancer. J Natl Cancer Inst Monogr. 2014;2014(50):346–58.CrossRefPubMedPubMedCentral
8.
go back to reference Greenlee H, DuPont-Reyes MJ, Balneaves LG, et al. Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA Cancer J Clin. 2017;67(3):194–232.CrossRefPubMedPubMedCentral Greenlee H, DuPont-Reyes MJ, Balneaves LG, et al. Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA Cancer J Clin. 2017;67(3):194–232.CrossRefPubMedPubMedCentral
9.
go back to reference Abrams DI. An integrative approach to prostate cancer. J Altern Complement Med. 2018;24(9–10):872–80.CrossRefPubMed Abrams DI. An integrative approach to prostate cancer. J Altern Complement Med. 2018;24(9–10):872–80.CrossRefPubMed
10.
go back to reference Oechsle K, Aslan Z, Suesse Y, Jensen W, Bokemeyer C, de Wit M. Multimodal exercise training during myeloablative chemotherapy: a prospective randomized pilot trial. Support Care Cancer. 2014;22(1):63–9.CrossRefPubMed Oechsle K, Aslan Z, Suesse Y, Jensen W, Bokemeyer C, de Wit M. Multimodal exercise training during myeloablative chemotherapy: a prospective randomized pilot trial. Support Care Cancer. 2014;22(1):63–9.CrossRefPubMed
11.
go back to reference • Cave J, Paschalis A, Huang CY, West M, Copson E, Jack S, et al. A systematic review of the safety and efficacy of aerobic exercise during cytotoxic chemotherapy treatment. Support Care Cancer. 2018. A systematic review that showed that aerobic exercise either maintained or improved patient fitness during chemotherapy, and should be encouraged.;26:3337–51.CrossRefPubMed • Cave J, Paschalis A, Huang CY, West M, Copson E, Jack S, et al. A systematic review of the safety and efficacy of aerobic exercise during cytotoxic chemotherapy treatment. Support Care Cancer. 2018. A systematic review that showed that aerobic exercise either maintained or improved patient fitness during chemotherapy, and should be encouraged.;26:3337–51.CrossRefPubMed
12.
go back to reference • Furzer BJ, Ackland TR, Wallman KE, Petterson AS, Gordon SM, Wright KE, et al. A randomised controlled trial comparing the effects of a 12-week supervised exercise versus usual care on outcomes in haematological cancer patients. Support Care Cancer. 2016;24(4):1697–707 A paper investigating the efficacy of a 12-week exercised rehabilitation program on cancer-related fatigue in patients with hematologic malignancy after receiving chemotherapy showed statistically significant outcomes and clinical improvement. CrossRefPubMed • Furzer BJ, Ackland TR, Wallman KE, Petterson AS, Gordon SM, Wright KE, et al. A randomised controlled trial comparing the effects of a 12-week supervised exercise versus usual care on outcomes in haematological cancer patients. Support Care Cancer. 2016;24(4):1697–707 A paper investigating the efficacy of a 12-week exercised rehabilitation program on cancer-related fatigue in patients with hematologic malignancy after receiving chemotherapy showed statistically significant outcomes and clinical improvement. CrossRefPubMed
13.
go back to reference Streckmann F, Kneis S, Leifert JA, Baumann FT, Kleber M, Ihorst G, et al. Exercise program improves therapy-related side-effects and quality of life in lymphoma patients undergoing therapy. Ann Oncol. 2014;25(2):493–9. Streckmann F, Kneis S, Leifert JA, Baumann FT, Kleber M, Ihorst G, et al. Exercise program improves therapy-related side-effects and quality of life in lymphoma patients undergoing therapy. Ann Oncol. 2014;25(2):493–9.
15.
go back to reference Courneya KS, Friedenreich CM, Franco-Villalobos C, Crawford JJ, Chua N, Basi S, et al. Effects of supervised exercise on progression-free survival in lymphoma patients: an exploratory follow-up of the HELP Trial. Cancer Causes Control. 2015;26(2):269–76.CrossRefPubMed Courneya KS, Friedenreich CM, Franco-Villalobos C, Crawford JJ, Chua N, Basi S, et al. Effects of supervised exercise on progression-free survival in lymphoma patients: an exploratory follow-up of the HELP Trial. Cancer Causes Control. 2015;26(2):269–76.CrossRefPubMed
16.
go back to reference van Haren I, Staal JB, Potting CM, et al. Physical exercise prior to hematopoietic stem cell transplantation: a feasibility study. Physiother Theory Pract. 2018;34(10):747–56.CrossRefPubMed van Haren I, Staal JB, Potting CM, et al. Physical exercise prior to hematopoietic stem cell transplantation: a feasibility study. Physiother Theory Pract. 2018;34(10):747–56.CrossRefPubMed
17.
go back to reference Bartels FR, Smith NS, Gorlov JS, et al. Optimized patient-trajectory for patients undergoing treatment with high-dose chemotherapy and autologous stem cell transplantation. Acta Oncol. 2015;54(5):750–8.CrossRefPubMed Bartels FR, Smith NS, Gorlov JS, et al. Optimized patient-trajectory for patients undergoing treatment with high-dose chemotherapy and autologous stem cell transplantation. Acta Oncol. 2015;54(5):750–8.CrossRefPubMed
18.
go back to reference Jacobsen PB, Le-Rademacher J, Jim H, et al. Exercise and stress management training prior to hematopoietic cell transplantation: Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0902. Biol Blood Marrow Transplant. 2014;20(10):1530–6.CrossRefPubMedPubMedCentral Jacobsen PB, Le-Rademacher J, Jim H, et al. Exercise and stress management training prior to hematopoietic cell transplantation: Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0902. Biol Blood Marrow Transplant. 2014;20(10):1530–6.CrossRefPubMedPubMedCentral
19.
go back to reference Keen C, Skilbeck J, Ross H, Smith L, Collins K, Dixey J, et al. Is it feasible to conduct a randomised controlled trial of pretransplant exercise (prehabilitation) for patients with multiple myeloma awaiting autologous haematopoietic stem cell transplantation? Protocol for the PREeMPT study. BMJ Open. 2018;8(3):e021333. Keen C, Skilbeck J, Ross H, Smith L, Collins K, Dixey J, et al. Is it feasible to conduct a randomised controlled trial of pretransplant exercise (prehabilitation) for patients with multiple myeloma awaiting autologous haematopoietic stem cell transplantation? Protocol for the PREeMPT study. BMJ Open. 2018;8(3):e021333.
20.
go back to reference •• Yun H, Sun L, Mao JJ. Growth of integrative medicine at leading cancer centers between 2009 and 2016: a systematic analysis of NCI-designated comprehensive cancer center websites. J Natl Cancer Inst Monogr. 2017;2017(52):lgx004. https://doi.org/10.1093/jncimonographs/lgx004. An investigation via a systematic review of 45 NCI comprehensive cancer center websites, of the growth of integrative medicine in US academic cancer centers, which finds that more and more cancer centers are providing integrative medicine practices to their patients. •• Yun H, Sun L, Mao JJ. Growth of integrative medicine at leading cancer centers between 2009 and 2016: a systematic analysis of NCI-designated comprehensive cancer center websites. J Natl Cancer Inst Monogr. 2017;2017(52):lgx004. https://​doi.​org/​10.​1093/​jncimonographs/​lgx004. An investigation via a systematic review of 45 NCI comprehensive cancer center websites, of the growth of integrative medicine in US academic cancer centers, which finds that more and more cancer centers are providing integrative medicine practices to their patients.
21.
go back to reference Armstrong K, Lanni T, Anderson MM, Patricolo GE. Integrative medicine and the oncology patient: options and benefits. Support Care Cancer. 2018;26(7):2267–73.CrossRefPubMed Armstrong K, Lanni T, Anderson MM, Patricolo GE. Integrative medicine and the oncology patient: options and benefits. Support Care Cancer. 2018;26(7):2267–73.CrossRefPubMed
22.
go back to reference Derry HM, Jaremka LM, Bennett JM, Peng J, Andridge R, Shapiro C, et al. Yoga and self-reported cognitive problems in breast cancer survivors: a randomized controlled trial. Psychooncology. 2015;24(8):958–66.CrossRefPubMed Derry HM, Jaremka LM, Bennett JM, Peng J, Andridge R, Shapiro C, et al. Yoga and self-reported cognitive problems in breast cancer survivors: a randomized controlled trial. Psychooncology. 2015;24(8):958–66.CrossRefPubMed
23.
go back to reference Sprod LK, Fernandez ID, Janelsins MC, Peppone LJ, Atkins JN, Giguere J, et al. Effects of yoga on cancer-related fatigue and global side-effect burden in older cancer survivors. J Geriatr Oncol. 2015;6(1):8–14. Sprod LK, Fernandez ID, Janelsins MC, Peppone LJ, Atkins JN, Giguere J, et al. Effects of yoga on cancer-related fatigue and global side-effect burden in older cancer survivors. J Geriatr Oncol. 2015;6(1):8–14.
25.
go back to reference Salhofer I, Will A, Monsef I, Skoetz N. Meditation for adults with haematological malignancies. Cochrane Database Syst Rev. 2016;2:Cd011157.PubMed Salhofer I, Will A, Monsef I, Skoetz N. Meditation for adults with haematological malignancies. Cochrane Database Syst Rev. 2016;2:Cd011157.PubMed
26.
go back to reference Huberty J, Eckert R, Gowin K, Mitchell J, Dueck AC, Ginos BF, et al. Feasibility study of online yoga for symptom management in patients with myeloproliferative neoplasms. Haematologica. 2017;102(10):e384–8.CrossRefPubMedPubMedCentral Huberty J, Eckert R, Gowin K, Mitchell J, Dueck AC, Ginos BF, et al. Feasibility study of online yoga for symptom management in patients with myeloproliferative neoplasms. Haematologica. 2017;102(10):e384–8.CrossRefPubMedPubMedCentral
27.
go back to reference Sattin RW, Easley KA, Wolf SL, Chen Y, Kutner MH. Reduction in fear of falling through intense tai chi exercise training in older, transitionally frail adults. J Am Geriatr Soc. 2005;53(7):1168–78.CrossRefPubMed Sattin RW, Easley KA, Wolf SL, Chen Y, Kutner MH. Reduction in fear of falling through intense tai chi exercise training in older, transitionally frail adults. J Am Geriatr Soc. 2005;53(7):1168–78.CrossRefPubMed
28.
go back to reference Zeng Y, Luo T, Xie H, Huang M, Cheng AS. Health benefits of qigong or tai chi for cancer patients: a systematic review and meta-analyses. Complement Ther Med. 2014;22(1):173–86.CrossRef Zeng Y, Luo T, Xie H, Huang M, Cheng AS. Health benefits of qigong or tai chi for cancer patients: a systematic review and meta-analyses. Complement Ther Med. 2014;22(1):173–86.CrossRef
29.
go back to reference • Wayne PM, Lee MS, Novakowski J, Osypiuk K, Ligibel J, Carlson LE, et al. Tai Chi and qigong for cancer-related symptoms and quality of life: a systematic review and meta-analysis. J Cancer Surviv. 2018;12(2):256–67 A summary on the effects of tai chi and qigong (TCQ) on quality of life in cancer survivors showing that, although there are noted improvements in areas like fatigue and depression, more studies are needed. CrossRefPubMed • Wayne PM, Lee MS, Novakowski J, Osypiuk K, Ligibel J, Carlson LE, et al. Tai Chi and qigong for cancer-related symptoms and quality of life: a systematic review and meta-analysis. J Cancer Surviv. 2018;12(2):256–67 A summary on the effects of tai chi and qigong (TCQ) on quality of life in cancer survivors showing that, although there are noted improvements in areas like fatigue and depression, more studies are needed. CrossRefPubMed
30.
go back to reference Tang YY, Hölzel BK, Posner MI. The neuroscience of mindfulness meditation. Nat Rev Neurosci. 2015;16(4):213–25. Tang YY, Hölzel BK, Posner MI. The neuroscience of mindfulness meditation. Nat Rev Neurosci. 2015;16(4):213–25.
32.
go back to reference Kutner JS, Smith MC, Corbin L, Hemphill L, Benton K, Mellis BK, et al. Massage therapy versus simple touch to improve pain and mood in patients with advanced cancer: a randomized trial. Ann Intern Med. 2008;149(6):369–79.CrossRefPubMedPubMedCentral Kutner JS, Smith MC, Corbin L, Hemphill L, Benton K, Mellis BK, et al. Massage therapy versus simple touch to improve pain and mood in patients with advanced cancer: a randomized trial. Ann Intern Med. 2008;149(6):369–79.CrossRefPubMedPubMedCentral
33.
go back to reference Frenkel M, Sapire K. Complementary and integrative medicine in hematologic malignancies: questions and challenges. Curr Oncol Rep. 2017;19(12):79.CrossRefPubMed Frenkel M, Sapire K. Complementary and integrative medicine in hematologic malignancies: questions and challenges. Curr Oncol Rep. 2017;19(12):79.CrossRefPubMed
34.
go back to reference Mehling WE, Lown EA, Dvorak CC, et al. Hematopoietic cell transplant and use of massage for improved symptom management: results from a pilot randomized control trial. Evid Based Complement Alternat Med. 2012;2012:450150.CrossRefPubMedPubMedCentral Mehling WE, Lown EA, Dvorak CC, et al. Hematopoietic cell transplant and use of massage for improved symptom management: results from a pilot randomized control trial. Evid Based Complement Alternat Med. 2012;2012:450150.CrossRefPubMedPubMedCentral
35.
go back to reference Davies E, Campbell S, Fullwood A, Hulbert J, Marks DI. The introduction of a holistic massage service in a combined paediatric and adult BMT unit. Bone Marrow Transplant. 2008;41(4):407–8.CrossRefPubMed Davies E, Campbell S, Fullwood A, Hulbert J, Marks DI. The introduction of a holistic massage service in a combined paediatric and adult BMT unit. Bone Marrow Transplant. 2008;41(4):407–8.CrossRefPubMed
36.
go back to reference Smith MC, Reeder F, Daniel L, Baramee J, Hagman J. Outcomes of touch therapies during bone marrow transplant. Altern Ther Health Med. 2003;9(1):40–9.PubMed Smith MC, Reeder F, Daniel L, Baramee J, Hagman J. Outcomes of touch therapies during bone marrow transplant. Altern Ther Health Med. 2003;9(1):40–9.PubMed
37.
go back to reference Tarantino B, Earley M, Audia D, D’Adamo C, Berman B. Qualitative and quantitative evaluation of a pilot integrative coping and resiliency program for healthcare professionals. Explore (NY). 2013;9(1):44–7.CrossRef Tarantino B, Earley M, Audia D, D’Adamo C, Berman B. Qualitative and quantitative evaluation of a pilot integrative coping and resiliency program for healthcare professionals. Explore (NY). 2013;9(1):44–7.CrossRef
38.
go back to reference Marcus DA, Blazek-O’Neill B, Kopar JL. Symptomatic improvement reported after receiving Reiki at a cancer infusion center. Am J Hosp Palliat Care. 2013;30(2):216–7.CrossRefPubMed Marcus DA, Blazek-O’Neill B, Kopar JL. Symptomatic improvement reported after receiving Reiki at a cancer infusion center. Am J Hosp Palliat Care. 2013;30(2):216–7.CrossRefPubMed
39.
go back to reference Birocco N, Guillame C, Storto S, Ritorto G, Catino C, Gir N, et al. The effects of Reiki therapy on pain and anxiety in patients attending a day oncology and infusion services unit. Am J Hosp Palliat Care. 2012;29(4):290–4.CrossRefPubMed Birocco N, Guillame C, Storto S, Ritorto G, Catino C, Gir N, et al. The effects of Reiki therapy on pain and anxiety in patients attending a day oncology and infusion services unit. Am J Hosp Palliat Care. 2012;29(4):290–4.CrossRefPubMed
40.
go back to reference •• Alarcão Z, Fonseca JRS. The effect of Reiki therapy on quality of life of patients with blood cancer: results from a randomized controlled trial. Eur J Integr Med. 2016;8(3):239–49 A Portuguese study to assess the effectiveness of Reiki on quality of life in patients with hematologic cancers, which suggests that Reiki may be effective and safe, and incorporable into the national health service. CrossRef •• Alarcão Z, Fonseca JRS. The effect of Reiki therapy on quality of life of patients with blood cancer: results from a randomized controlled trial. Eur J Integr Med. 2016;8(3):239–49 A Portuguese study to assess the effectiveness of Reiki on quality of life in patients with hematologic cancers, which suggests that Reiki may be effective and safe, and incorporable into the national health service. CrossRef
41.
go back to reference •• Lyman GH, Bohlke K, Cohen L. Integrative therapies during and after breast cancer treatment: ASCO endorsement of the SIO clinical practice guideline summary. J Oncol Pract. 2018;14(8):495–9 ASCO endorsement of the Society of Integrative Oncology’s guidelines on the use of integrative therapies during and after breast cancer treatment. CrossRefPubMed •• Lyman GH, Bohlke K, Cohen L. Integrative therapies during and after breast cancer treatment: ASCO endorsement of the SIO clinical practice guideline summary. J Oncol Pract. 2018;14(8):495–9 ASCO endorsement of the Society of Integrative Oncology’s guidelines on the use of integrative therapies during and after breast cancer treatment. CrossRefPubMed
42.
go back to reference •• Deng GE, Giralt S, Chung DJ, Landau HJ, Siman J, Search B, et al. Acupuncture for symptom reduction in myeloma patients undergoing hematopoietic stem cell transplantation: a randomized, sham-controlled trial. J Clin Oncol. 2017;35(15). A randomized sham-controlled trial evaluating the efficacy and safety of acupuncture in patients undergoing hematopoietic stem cell transplants that concluded that acupuncture is well tolerated and may reduce pain):8021.CrossRef •• Deng GE, Giralt S, Chung DJ, Landau HJ, Siman J, Search B, et al. Acupuncture for symptom reduction in myeloma patients undergoing hematopoietic stem cell transplantation: a randomized, sham-controlled trial. J Clin Oncol. 2017;35(15). A randomized sham-controlled trial evaluating the efficacy and safety of acupuncture in patients undergoing hematopoietic stem cell transplants that concluded that acupuncture is well tolerated and may reduce pain):8021.CrossRef
43.
go back to reference Han X, Wang L, Shi H, Zheng G, He J, Wu W, et al. Acupuncture combined with methylcobalamin for the treatment of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma. BMC Cancer. 2017;17(1):40.CrossRefPubMedPubMedCentral Han X, Wang L, Shi H, Zheng G, He J, Wu W, et al. Acupuncture combined with methylcobalamin for the treatment of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma. BMC Cancer. 2017;17(1):40.CrossRefPubMedPubMedCentral
44.
go back to reference Bao T, Goloubeva O, Pelser C, Porter N, Primrose J, Hester L, et al. A pilot study of acupuncture in treating bortezomib-induced peripheral neuropathy in patients with multiple myeloma. Integr Cancer Ther. 2014;13(5):396–404.CrossRefPubMedPubMedCentral Bao T, Goloubeva O, Pelser C, Porter N, Primrose J, Hester L, et al. A pilot study of acupuncture in treating bortezomib-induced peripheral neuropathy in patients with multiple myeloma. Integr Cancer Ther. 2014;13(5):396–404.CrossRefPubMedPubMedCentral
45.
go back to reference Lu W, Rosenthal DS. Recent advances in oncology acupuncture and safety considerations in practice. Curr Treat Options in Oncol. 2010;11(3–4):141–6.CrossRef Lu W, Rosenthal DS. Recent advances in oncology acupuncture and safety considerations in practice. Curr Treat Options in Oncol. 2010;11(3–4):141–6.CrossRef
46.
go back to reference Fu H, Chen B, Hong S, Guo Y. Acupuncture therapy for the treatment of myelosuppression after chemotherapy: a literature review over the past 10 years. J Acupunct Meridian Stud. 2015;8(3):122–6.CrossRefPubMed Fu H, Chen B, Hong S, Guo Y. Acupuncture therapy for the treatment of myelosuppression after chemotherapy: a literature review over the past 10 years. J Acupunct Meridian Stud. 2015;8(3):122–6.CrossRefPubMed
47.
go back to reference Pais I, Correia N, Pimentel I, et al. Effects of acupuncture on leucopenia, neutropenia, NK, and B cells in cancer patients: a randomized pilot study. Evid Based Complement Alternat Med. 2014;2014:217397.CrossRefPubMedPubMedCentral Pais I, Correia N, Pimentel I, et al. Effects of acupuncture on leucopenia, neutropenia, NK, and B cells in cancer patients: a randomized pilot study. Evid Based Complement Alternat Med. 2014;2014:217397.CrossRefPubMedPubMedCentral
48.
go back to reference Fortner RT, Katzke V, Kühn T, Kaaks R. Obesity and Breast Cancer. Recent Results Cancer Res. 2016;208:43–65.CrossRefPubMed Fortner RT, Katzke V, Kühn T, Kaaks R. Obesity and Breast Cancer. Recent Results Cancer Res. 2016;208:43–65.CrossRefPubMed
49.
go back to reference Bertrand KA, Giovannucci E, Rosner BA, Zhang SM, Laden F, Birmann BM. Dietary fat intake and risk of non-Hodgkin lymphoma in 2 large prospective cohorts. Am J Clin Nutr. 2017;106(2):650–6.CrossRefPubMedPubMedCentral Bertrand KA, Giovannucci E, Rosner BA, Zhang SM, Laden F, Birmann BM. Dietary fat intake and risk of non-Hodgkin lymphoma in 2 large prospective cohorts. Am J Clin Nutr. 2017;106(2):650–6.CrossRefPubMedPubMedCentral
50.
go back to reference Shai A, Morr M, Uzan A, Koren O. Changes in the microbiome induced by adjuvant chemotherapy for breast and gynecological cancer and their association with weight gain. J Clin Oncol. 2018;36(15_suppl):e22113.CrossRef Shai A, Morr M, Uzan A, Koren O. Changes in the microbiome induced by adjuvant chemotherapy for breast and gynecological cancer and their association with weight gain. J Clin Oncol. 2018;36(15_suppl):e22113.CrossRef
51.
go back to reference • Peled JU, Devlin SM, Staffas A, Lumish M, Khanin R, Littmann ER, et al. Intestinal microbiota and relapse after hematopoietic-cell transplantation. J Clin Oncol. 2017;35(15):1650–9 A retrospective discovery-validation cohort study on patients following allo-HCT, showing that abundance of the gut bacteria, Eubacterium limosum , is associated with decreased risk of disease relapse and progression. CrossRefPubMedPubMedCentral • Peled JU, Devlin SM, Staffas A, Lumish M, Khanin R, Littmann ER, et al. Intestinal microbiota and relapse after hematopoietic-cell transplantation. J Clin Oncol. 2017;35(15):1650–9 A retrospective discovery-validation cohort study on patients following allo-HCT, showing that abundance of the gut bacteria, Eubacterium limosum , is associated with decreased risk of disease relapse and progression. CrossRefPubMedPubMedCentral
52.
go back to reference Biagi E, Nylund L, Candela M, Ostan R, Bucci L, Pini E, et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One. 2010;5(5):e10667.CrossRefPubMedPubMedCentral Biagi E, Nylund L, Candela M, Ostan R, Bucci L, Pini E, et al. Through ageing, and beyond: gut microbiota and inflammatory status in seniors and centenarians. PLoS One. 2010;5(5):e10667.CrossRefPubMedPubMedCentral
53.
go back to reference Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell. 2010;140(2):197–208.CrossRefPubMedPubMedCentral Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, et al. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell. 2010;140(2):197–208.CrossRefPubMedPubMedCentral
54.
go back to reference Butturini AM, Dorey FJ, Lange BJ, Henry DW, Gaynon PS, Fu C, et al. Obesity and outcome in pediatric acute lymphoblastic leukemia. J Clin Oncol. 2007;25(15):2063–9.CrossRefPubMed Butturini AM, Dorey FJ, Lange BJ, Henry DW, Gaynon PS, Fu C, et al. Obesity and outcome in pediatric acute lymphoblastic leukemia. J Clin Oncol. 2007;25(15):2063–9.CrossRefPubMed
55.
go back to reference Lange BJ, Gerbing RB, Feusner J, et al. Mortality in overweight and underweight children with acute myeloid leukemia. JAMA. 2005;293(2):203–11.CrossRefPubMed Lange BJ, Gerbing RB, Feusner J, et al. Mortality in overweight and underweight children with acute myeloid leukemia. JAMA. 2005;293(2):203–11.CrossRefPubMed
56.
go back to reference Ligibel JA, Alfano CM, Courneya KS, Demark-Wahnefried W, Burger RA, Chlebowski RT, et al. American Society of Clinical Oncology position statement on obesity and cancer. J Clin Oncol. 2014;32(31):3568–74.CrossRefPubMedPubMedCentral Ligibel JA, Alfano CM, Courneya KS, Demark-Wahnefried W, Burger RA, Chlebowski RT, et al. American Society of Clinical Oncology position statement on obesity and cancer. J Clin Oncol. 2014;32(31):3568–74.CrossRefPubMedPubMedCentral
57.
go back to reference Ammann EM, Drake MT, Haraldsson B, Wallace RB, Johnson KC, Desai P, et al. Incidence of hematologic malignancy and cause-specific mortality in the Women’s Health Initiative randomized controlled trial of calcium and vitamin D supplementation. Cancer. 2017;123(21):4168–77.CrossRefPubMedPubMedCentral Ammann EM, Drake MT, Haraldsson B, Wallace RB, Johnson KC, Desai P, et al. Incidence of hematologic malignancy and cause-specific mortality in the Women’s Health Initiative randomized controlled trial of calcium and vitamin D supplementation. Cancer. 2017;123(21):4168–77.CrossRefPubMedPubMedCentral
58.
go back to reference Chagas TR, Borges DS, de Oliveira PF, Mocellin MC, Barbosa AM, Camargo CQ, et al. Oral fish oil positively influences nutritional-inflammatory risk in patients with haematological malignancies during chemotherapy with an impact on long-term survival: a randomised clinical trial. J Hum Nutr Diet. 2017;30(6):681–92.CrossRefPubMed Chagas TR, Borges DS, de Oliveira PF, Mocellin MC, Barbosa AM, Camargo CQ, et al. Oral fish oil positively influences nutritional-inflammatory risk in patients with haematological malignancies during chemotherapy with an impact on long-term survival: a randomised clinical trial. J Hum Nutr Diet. 2017;30(6):681–92.CrossRefPubMed
59.
go back to reference Kooti W, Servatyari K, Behzadifar M, Asadi-Samani M, Sadeghi F, Nouri B, et al. Effective medicinal plant in cancer treatment, part 2: review study. J Evid Based Complementary Altern Med. 2017;22(4):982–95.CrossRefPubMedPubMedCentral Kooti W, Servatyari K, Behzadifar M, Asadi-Samani M, Sadeghi F, Nouri B, et al. Effective medicinal plant in cancer treatment, part 2: review study. J Evid Based Complementary Altern Med. 2017;22(4):982–95.CrossRefPubMedPubMedCentral
60.
go back to reference • Bahmani F, Esmaeili S, Bashash D, Dehghan-Nayeri N, Mashati P, Gharehbaghian A. Centaurea albonitens extract enhances the therapeutic effects of vincristine in leukemic cells by inducing apoptosis. Biomed Pharmacother. 2018;99:598–607 A study of the potential cytotoxic effects of Centaurea albonitens extract (CAE) alone and combined with vincristine in leukemic cells that shows that CAE is a potential anticancer agent, and an enhancer of vincristine chemotherapeutic effects. CrossRefPubMed • Bahmani F, Esmaeili S, Bashash D, Dehghan-Nayeri N, Mashati P, Gharehbaghian A. Centaurea albonitens extract enhances the therapeutic effects of vincristine in leukemic cells by inducing apoptosis. Biomed Pharmacother. 2018;99:598–607 A study of the potential cytotoxic effects of Centaurea albonitens extract (CAE) alone and combined with vincristine in leukemic cells that shows that CAE is a potential anticancer agent, and an enhancer of vincristine chemotherapeutic effects. CrossRefPubMed
61.
go back to reference Shanafelt TD, Drake MT, Maurer MJ, Allmer C, Rabe KG, Slager SL, et al. Vitamin D insufficiency and prognosis in chronic lymphocytic leukemia. Blood. 2011;117(5):1492–8.CrossRefPubMedPubMedCentral Shanafelt TD, Drake MT, Maurer MJ, Allmer C, Rabe KG, Slager SL, et al. Vitamin D insufficiency and prognosis in chronic lymphocytic leukemia. Blood. 2011;117(5):1492–8.CrossRefPubMedPubMedCentral
62.
go back to reference Kubeczko M, Nowara E, Spychalowicz W, et al. Efficacy and safety of vitamin D supplementation in patients with chronic lymphocytic leukemia. Postepy Hig Med Dosw (Online). 2016;70(0):534–41.CrossRef Kubeczko M, Nowara E, Spychalowicz W, et al. Efficacy and safety of vitamin D supplementation in patients with chronic lymphocytic leukemia. Postepy Hig Med Dosw (Online). 2016;70(0):534–41.CrossRef
63.
go back to reference Liu P, Holman CDJ, Jin J, Zhang M. Green tea consumption is associated with a reduced risk of adult leukemia. Asia Pac J Clin Oncol. 2014;10:10.CrossRef Liu P, Holman CDJ, Jin J, Zhang M. Green tea consumption is associated with a reduced risk of adult leukemia. Asia Pac J Clin Oncol. 2014;10:10.CrossRef
64.
go back to reference Borutinskaitė V, Virkšaitė A, Gudelytė G, Navakauskienė R. Green tea polyphenol EGCG causes anti-cancerous epigenetic modulations in acute promyelocytic leukemia cells. Leuk Lymphoma. 2018;59(2):469–78.CrossRefPubMed Borutinskaitė V, Virkšaitė A, Gudelytė G, Navakauskienė R. Green tea polyphenol EGCG causes anti-cancerous epigenetic modulations in acute promyelocytic leukemia cells. Leuk Lymphoma. 2018;59(2):469–78.CrossRefPubMed
65.
go back to reference • Pimentel-GutiéRrez HJ, Bobadilla-Morales L, Barba-Barba CC, et al. Curcumin potentiates the effect of chemotherapy against acute lymphoblastic leukemia cells via downregulation of NF-κ B. Oncol Lett. 2016;12(5):4117–24 Green Tea Catechin epigallocatechin-3-gallate (EGCG) may be able to halt cell proliferation, act as an epigenetic modifier, and even cause apoptosis in acute promyelocytic leukemia. CrossRefPubMedPubMedCentral • Pimentel-GutiéRrez HJ, Bobadilla-Morales L, Barba-Barba CC, et al. Curcumin potentiates the effect of chemotherapy against acute lymphoblastic leukemia cells via downregulation of NF-κ B. Oncol Lett. 2016;12(5):4117–24 Green Tea Catechin epigallocatechin-3-gallate (EGCG) may be able to halt cell proliferation, act as an epigenetic modifier, and even cause apoptosis in acute promyelocytic leukemia. CrossRefPubMedPubMedCentral
66.
go back to reference Herviou L, Kassambara A, Boireau S, Robert N, Requirand G, Müller-Tidow C, et al. PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs. Clin Epigenetics. 2018;10(1):121.CrossRefPubMedPubMedCentral Herviou L, Kassambara A, Boireau S, Robert N, Requirand G, Müller-Tidow C, et al. PRC2 targeting is a therapeutic strategy for EZ score defined high-risk multiple myeloma patients and overcome resistance to IMiDs. Clin Epigenetics. 2018;10(1):121.CrossRefPubMedPubMedCentral
67.
go back to reference Zhang Y, Kong Y, Liu S, Zeng L, Wan L, Zhang Z. Curcumin induces apoptosis in human leukemic cell lines through an IFIT2-dependent pathway. Cancer Biol Ther. 2017;18(1):43–50.CrossRefPubMedPubMedCentral Zhang Y, Kong Y, Liu S, Zeng L, Wan L, Zhang Z. Curcumin induces apoptosis in human leukemic cell lines through an IFIT2-dependent pathway. Cancer Biol Ther. 2017;18(1):43–50.CrossRefPubMedPubMedCentral
68.
go back to reference Wu C, Ruan T, Liu W, Zhu X, Pan J, Lu W, et al. Effect and mechanism of curcumin on EZH2 - MiR-101 regulatory feedback loop in multiple myeloma. Curr Pharm Des. 2018;24(5):564–75.CrossRefPubMed Wu C, Ruan T, Liu W, Zhu X, Pan J, Lu W, et al. Effect and mechanism of curcumin on EZH2 - MiR-101 regulatory feedback loop in multiple myeloma. Curr Pharm Des. 2018;24(5):564–75.CrossRefPubMed
69.
go back to reference Han TJ, Li JS, Luan XT, Wang L, Xu HZ. Dietary fat consumption and non-Hodgkin’s lymphoma risk: a meta-analysis. Nutr Cancer. 2017;69(2):221–8.CrossRefPubMed Han TJ, Li JS, Luan XT, Wang L, Xu HZ. Dietary fat consumption and non-Hodgkin’s lymphoma risk: a meta-analysis. Nutr Cancer. 2017;69(2):221–8.CrossRefPubMed
Metadata
Title
Emerging Role of Integrative Medicine in Hematologic Malignancies: a Literature Review and Update on Current Trends in Complementary Medical Practices in Hematologic Cancers
Authors
Onyemaechi N. Okolo
Krisstina Gowin
Publication date
01-08-2019
Publisher
Springer US
Published in
Current Hematologic Malignancy Reports / Issue 4/2019
Print ISSN: 1558-8211
Electronic ISSN: 1558-822X
DOI
https://doi.org/10.1007/s11899-019-00526-8

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