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Current Hematologic Malignancy Reports
Published in: Current Hematologic Malignancy Reports 6/2018

01-12-2018 | B-cell NHL, T-cell NHL, and Hodgkin Lymphoma (J Amengual, Section Editor)

Anti-CD19 Chimeric Antigen Receptor T Cell Therapies: Harnessing the Power of the Immune System to Fight Diffuse Large B Cell Lymphoma

Authors: Robert Havard, Deborah M. Stephens

Published in: Current Hematologic Malignancy Reports | Issue 6/2018

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Abstract

Purpose of Review

This article will review the use of anti-CD19 CAR-T therapy used in relapsed/refractory diffuse large B cell lymphoma.

Recent Findings

The clinical outcomes, safety analysis, and other relevant considerations will be discussed with an emphasis on the most recently published data regarding the ZUMA-1, JULIET, and TRANSCEND NHL-001 trials.

Summary

Anti-CD19 CAR-T therapy is an exciting new therapy now approved and available to patients with relapsed/refractory diffuse large B cell lymphoma. Secondary to the increasing success and availability of these products, caregivers should expect to become familiar with the indications, toxicity, and limitations of these treatment options and when patients should be considered for referral.
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Metadata
Title
Anti-CD19 Chimeric Antigen Receptor T Cell Therapies: Harnessing the Power of the Immune System to Fight Diffuse Large B Cell Lymphoma
Authors
Robert Havard
Deborah M. Stephens
Publication date
01-12-2018
Publisher
Springer US
Published in
Current Hematologic Malignancy Reports / Issue 6/2018
Print ISSN: 1558-8211
Electronic ISSN: 1558-822X
DOI
https://doi.org/10.1007/s11899-018-0482-6

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