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Current Hematologic Malignancy Reports
Published in: Current Hematologic Malignancy Reports 4/2017

01-08-2017 | CART and Immunotherapy (M Ruella, Section Editor)

Targeting Immune System Alterations in Hodgkin Lymphoma

Authors: Natalie S. Grover, Barbara Savoldo

Published in: Current Hematologic Malignancy Reports | Issue 4/2017

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Abstract

Purpose of Review

This review discusses novel immunotherapeutic approaches to treat Hodgkin lymphoma (HL), specifically PD-1 inhibitors and cellular immunotherapy.

Recent Findings

PD-1 inhibitors have shown promising results in the treatment of relapsed or refractory HL, leading to FDA approval of nivolumab and pembrolizumab, although complete remissions are rare. Chimeric antigen receptor T cells directed against CD30 have been investigated with preliminary clinical trials showing minimal toxicities and some responses in heavily pre-treated patients with HL.

Summary

HL is unique as it consists of a small percentage of malignant cells (Hodgkin Reed Sternberg cells) surrounded by an inflammatory microenvironment which promotes tumor growth and suppresses immune responses, making it an ideal target for immunotherapeutic approaches, such as PD-1 inhibitors and cellular immunotherapy. Current research is focused on overcoming barriers to efficacy via rational combinations that overcome resistance to therapy.
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Metadata
Title
Targeting Immune System Alterations in Hodgkin Lymphoma
Authors
Natalie S. Grover
Barbara Savoldo
Publication date
01-08-2017
Publisher
Springer US
Published in
Current Hematologic Malignancy Reports / Issue 4/2017
Print ISSN: 1558-8211
Electronic ISSN: 1558-822X
DOI
https://doi.org/10.1007/s11899-017-0398-6

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