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01-04-2017 | Multiple Myeloma (P Kapoor, Section Editor)

CARs in the Lead Against Multiple Myeloma

Authors: Maria Ormhøj, Felipe Bedoya, Matthew J. Frigault, Marcela V. Maus

Published in: Current Hematologic Malignancy Reports | Issue 2/2017

Abstract

The recent clinical success of CD19-directed chimeric antigen receptor (CAR) T cell therapy in chronic and acute leukemia has led to increased interest in broadening this technology to other hematological malignancies and solid tumors. Now, advances are being made using CAR T cell technology to target myeloma antigens such as B cell maturation antigen (BCMA), CD138, and kappa-light chain as well as CD19 on putative myeloma stem cells. To date, only a limited number of multiple myeloma patients have received CAR T cell therapy but preliminary results have been encouraging. In this review, we summarize the recently reported results of clinical trials conducted utilizing CAR T cell therapy in multiple myeloma (MM).

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Title: CARs in the Lead Against Multiple Myeloma
Authors: Maria Ormhøj
Felipe Bedoya
Matthew J. Frigault
Marcela V. Maus
Publication date: 01-04-2017
Publisher: Springer US
Published in: Current Hematologic Malignancy Reports / Issue 2/2017
Print ISSN: 1558-8211
Electronic ISSN: 1558-822X
DOI: https://doi.org/10.1007/s11899-017-0373-2

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