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Current Heart Failure Reports
Published in: Current Heart Failure Reports 5/2020

01-10-2020 | Heart Failure | Biomarkers of Heart Failure (WH Tang & J Grodin, Section Editors)

Evidence of Clonal Hematopoiesis and Risk of Heart Failure

Authors: Peter Bazeley, Rommel Morales, W. H. Wilson Tang

Published in: Current Heart Failure Reports | Issue 5/2020

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Abstract

Purpose of Review

Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by persistent clonal expansion of adult hematopoietic stem cells, which has been increasingly found to be associated with cardiovascular disease and adverse outcomes in heart failure. Here we outline emerging studies on the prevalence of CHIP, and its association with cardiovascular and heart disease.

Recent Findings

Previous genomic studies have found CHIP mutations to be associated with increased risks of arterial disease, stroke, and mortality. Murine studies exploring TET2, DNMT3A, and JAK2 mutations have shown changes in cellularity that decrease cardiac function after insult, as well as increase inflammasome activation.

Summary

Mutations in driver genes are associated with worse clinical outcomes in heart failure patients, as a potential result of the proinflammatory selection in clonal hematopoiesis. Advances in the field have yielded therapeutic targets tested in recent clinical studies and may provide a valuable diagnostic of risk in heart failure.
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Metadata
Title
Evidence of Clonal Hematopoiesis and Risk of Heart Failure
Authors
Peter Bazeley
Rommel Morales
W. H. Wilson Tang
Publication date
01-10-2020
Publisher
Springer US
Keyword
Heart Failure
Published in
Current Heart Failure Reports / Issue 5/2020
Print ISSN: 1546-9530
Electronic ISSN: 1546-9549
DOI
https://doi.org/10.1007/s11897-020-00476-w

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