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Current Gastroenterology Reports
Published in: Current Gastroenterology Reports 11/2017

01-11-2017 | Neurogastroenterology and Motility Disorders of the Gastrointestinal Tract (S Rao, Section Editor)

Post-Infectious Irritable Bowel Syndrome

Authors: Yeong Yeh Lee, Chandramouli Annamalai, Satish S. C. Rao

Published in: Current Gastroenterology Reports | Issue 11/2017

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Abstract

Purpose of Review

Post-infectious irritable bowel syndrome (PI-IBS) is characterized by persistent abdominal pain and diarrhea, typically following an episode of infectious gastroenteritis. The mechanisms that underlie IBS-D remain elusive, but PI-IBS provides a mechanistic model of this disorder. This review provides an up-to-date appraisal of the pathophysiology, clinical features, and management approaches for PI-IBS.

Recent Findings

Disordered immune reactions and release of cytokines with resultant gut inflammation and dysfunction appear to be key features of PI-IBS. Disordered brain-gut-microbiota interactions, type of infecting agent, and host-genetic susceptibility are risk factors but also are reasons for the varying spectrum of clinical severity. Although prognosis is generally good, symptoms and inflammation may persist for a long time. Symptomatic relief with antidiarrheals, antispasmodics, 5HT3 antagonists, mesalamine, probiotics, and low-dose antidepressants remain the primary approaches, but in some difficult cases, a combination of drugs that target the pathophysiology may be helpful.

Summary

PI-IBS has many overlapping features with IBS-D and shares similar pathophysiology and management approaches.
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Metadata
Title
Post-Infectious Irritable Bowel Syndrome
Authors
Yeong Yeh Lee
Chandramouli Annamalai
Satish S. C. Rao
Publication date
01-11-2017
Publisher
Springer US
Published in
Current Gastroenterology Reports / Issue 11/2017
Print ISSN: 1522-8037
Electronic ISSN: 1534-312X
DOI
https://doi.org/10.1007/s11894-017-0595-4

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