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Current Diabetes Reports

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01-01-2019 | Type 2 Diabetes | Pediatric Type 2 and Monogenic Diabetes (O Pinhas-Hamiel, Section Editor)

Youth-Onset Type 2 Diabetes and the Developing Brain

Authors: Jacob M. Redel, Lawrence M. Dolan, Mark DiFrancesco, Jennifer Vannest, Amy S. Shah

Published in: Current Diabetes Reports | Issue 1/2019

Abstract

Purpose of Review

This review describes the literature evaluating the potential adverse effects of youth-onset type 2 diabetes on the developing brain. A summary of recently published articles and the current state of knowledge are covered succinctly in this manuscript.

Recent Findings

Current literature suggests both cognitive and brain structural differences are found in youth with type 2 diabetes. Studies have shown poorer scores in a number of neurocognitive domains, particularly in areas of executive functioning and memory. Additionally, imaging studies have found differences in brain gray matter volume, white matter volume, and microstructural integrity. These findings are largely consistent with the adult literature.

Summary

Youth with type 2 diabetes demonstrate lower cognitive scores and structural brain differences. Although causality has not yet been established, these findings are important because these individuals are still undergoing neurodevelopmental maturation.

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Title: Youth-Onset Type 2 Diabetes and the Developing Brain
Authors: Jacob M. Redel
Lawrence M. Dolan
Mark DiFrancesco
Jennifer Vannest
Amy S. Shah
Publication date: 01-01-2019
Publisher: Springer US
Keyword: Type 2 Diabetes
Published in: Current Diabetes Reports / Issue 1/2019
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI: https://doi.org/10.1007/s11892-019-1120-y

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Youth-Onset Type 2 Diabetes and the Developing Brain

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Please log in to get access to this content

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Year in Review: Heart failure and cardiomyopathies

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

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New intervention for STEMI-related cardiogenic shock

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