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Current Diabetes Reports
Published in: Current Diabetes Reports 10/2018

01-10-2018 | Diabetes and Pregnancy (M-F Hivert and CE Powe, Section Editors)

Prediction and Prevention of Type 2 Diabetes in Women with a History of GDM

Author: Deirdre K. Tobias

Published in: Current Diabetes Reports | Issue 10/2018

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Abstract

Purpose of the Review

Women with a history of gestational diabetes mellitus (GDM) have an alarmingly high risk of developing type 2 diabetes (T2D); yet, mechanisms underlying this progression are largely unknown.

Recent Findings

Clinical characteristics of a GDM pregnancy and postpartum metabolomics may contribute to risk prediction of T2D to identify those women at highest risk of progression and need for intervention. Evidence for effective postpartum lifestyle interventions from observational studies include adherence to a healthy dietary pattern, increasing physical activity, and maintaining a healthy body weight. Larger clinical trials with greater participant engagement are warranted to confirm the effectiveness of lifestyle interventions in women with recent GDM.

Summary

Research is needed to refine prediction models of T2D after GDM, and to determine the most effective strategies to delay or prevent T2D onset. Incorporating novel biomarkers in the postpartum period, such as metabolomics, could offer a powerful approach.
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Metadata
Title
Prediction and Prevention of Type 2 Diabetes in Women with a History of GDM
Author
Deirdre K. Tobias
Publication date
01-10-2018
Publisher
Springer US
Published in
Current Diabetes Reports / Issue 10/2018
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-018-1063-8

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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