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At a glance: The ONWARDS insulin icodec trials

A round-up of the ONWARDS phase 3 clinical trials evaluating the novel weekly insulin icodec in people with diabetes.
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Current Diabetes Reports
Published in: Current Diabetes Reports 11/2016

01-11-2016 | Lifestyle Management to Reduce Diabetes/Cardiovascular Risk (C Shay and B Conway, Section Editors)

Sleep Duration and Diabetes Risk: Population Trends and Potential Mechanisms

Authors: Michael A. Grandner, Azizi Seixas, Safal Shetty, Sundeep Shenoy

Published in: Current Diabetes Reports | Issue 11/2016

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Abstract

Sleep is important for regulating many physiologic functions that relate to metabolism. Because of this, there is substantial evidence to suggest that sleep habits and sleep disorders are related to diabetes risk. In specific, insufficient sleep duration and/or sleep restriction in the laboratory, poor sleep quality, and sleep disorders such as insomnia and sleep apnea have all been associated with diabetes risk. This research spans epidemiologic and laboratory studies. Both physiologic mechanisms such as insulin resistance, decreased leptin, and increased ghrelin and inflammation and behavioral mechanisms such as increased food intake, impaired decision-making, and increased likelihood of other behavioral risk factors such as smoking, sedentary behavior, and alcohol use predispose to both diabetes and obesity, which itself is an important diabetes risk factor. This review describes the evidence linking sleep and diabetes risk at the population and laboratory levels.
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Metadata
Title
Sleep Duration and Diabetes Risk: Population Trends and Potential Mechanisms
Authors
Michael A. Grandner
Azizi Seixas
Safal Shetty
Sundeep Shenoy
Publication date
01-11-2016
Publisher
Springer US
Published in
Current Diabetes Reports / Issue 11/2016
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-016-0805-8

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Microvascular Complications—Neuropathy (R Pop-Busui, Section Editor)

Integrated Cardio-Respiratory Control: Insight in Diabetes

Lifestyle Management to Reduce Diabetes/Cardiovascular Risk (C Shay and B Conway, Section Editors)

Self-Care Disparities Among Adults with Type 2 Diabetes in the USA

Microvascular Complications—Nephropathy (AP Maxwell, Section Editor)

Urinary Proteomics for Diagnosis and Monitoring of Diabetic Nephropathy

Health Care Delivery Systems and Implementation in Diabetes (EB Morton-Eggleston and ME McDonnell, Section Editors)

Caring for People with Diabetes at the End of Life

Obesity (J McCaffery, Section Editor)

Racial/Ethnic Residential Segregation, Obesity, and Diabetes Mellitus

Pathogenesis of Type 1 Diabetes (A Pugliese, Section Editor)

The Expanding Role of Natural Killer Cells in Type 1 Diabetes and Immunotherapy

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