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Current Diabetes Reports
Published in: Current Diabetes Reports 1/2016

01-01-2016 | Pediatric Type 2 Diabetes (PS Zeitler, Section Editor)

Metabolic Syndrome in Children and Adolescents: a Critical Approach Considering the Interaction between Pubertal Stage and Insulin Resistance

Author: Thomas Reinehr

Published in: Current Diabetes Reports | Issue 1/2016

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Abstract

Pediatricians increasingly diagnose the metabolic syndrome (MetS) in recent years to describe cardiovascular risk and to guide management of the obese child. However, there is an ongoing discussion about how to define the MetS in childhood and adolescence. Since insulin resistance—the major driver of MetS—is influenced by pubertal stage, it is questionable to use definitions for MetS in children and adolescents that do not take into account pubertal status. A metabolic healthy status in prepubertal stage does not predict a metabolic healthy status during puberty. Furthermore, cardiovascular risk factors improve at the end of puberty without treatment. However, having a uniform internationally accepted definition of the MetS for children and adolescents would be very helpful for the description of populations in different studies. Therefore, the concept of MetS has to be revisited under the influence of puberty stage.
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Metadata
Title
Metabolic Syndrome in Children and Adolescents: a Critical Approach Considering the Interaction between Pubertal Stage and Insulin Resistance
Author
Thomas Reinehr
Publication date
01-01-2016
Publisher
Springer US
Published in
Current Diabetes Reports / Issue 1/2016
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-015-0695-1

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