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Published in:

01-10-2015 | Treatment of Type 1 Diabetes (M Pietropaolo, Section Editor)

Management of Severe Insulin Resistance in Patients with Type 1 Diabetes

Authors: Rebecca Schechter, Sirimon Reutrakul

Published in: Current Diabetes Reports | Issue 10/2015

Abstract

Managing severe insulin resistance (IR) in patients with type 1 diabetes (T1DM) can be challenging for both clinicians and patients. As average weight for patients with T1DM has increased in recent decades, IR in this population has become more widespread. Currently, almost 50 % of patients with T1DM are overweight or obese. While intensive insulin therapy is associated with reduction in complications, aggressive treatment can lead to weight gain. With increasing weight, insulin can become less effective to control glycemia, resulting in higher insulin doses and hence more weight gain. Novel strategies to break this vicious cycle are needed. This review will investigate current research on insulin formulations, lifestyle modification, adjunct therapies, and surgery that may help better manage patients with T1DM and IR.

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Title: Management of Severe Insulin Resistance in Patients with Type 1 Diabetes
Authors: Rebecca Schechter
Sirimon Reutrakul
Publication date: 01-10-2015
Publisher: Springer US
Published in: Current Diabetes Reports / Issue 10/2015
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI: https://doi.org/10.1007/s11892-015-0641-2

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