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At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
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Current Diabetes Reports
Published in: Current Diabetes Reports 5/2014

01-05-2014 | Pharmacologic Treatment of Type 2 Diabetes (A Vella, Section Editor)

Cardiovascular Actions of GLP-1 and Incretin-Based Pharmacotherapy

Authors: Angelo Avogaro, Saula Vigili de Kreutzenberg, Gian Paolo Fadini

Published in: Current Diabetes Reports | Issue 5/2014

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Abstract

Incretin-based therapy became recently available as antihyperglycemic treatment for patients with type 2 diabetes (T2DM). Incretin therapy comprises glucagon-like peptide receptor agonists (GLP-1RA) and dipeptidyl-peptidase 4 inhibitors (DPP4-I): these classes of drugs not only have the ability to reduce blood glucose, but also can exert several cardioprotective effects. They have been shown to positively influence some risk factors for cardiovascular disease (CVD), to improve endothelial function, and to directly affect cardiac function. For these reasons incretins are considered not only antidiabetic drugs, but also cardiovascular effective. The first clinical trials aimed to demonstrate the safety of DPP4 inhibitors have been recently published: their clinical significance will be discussed in light of the prior experimental findings.
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Metadata
Title
Cardiovascular Actions of GLP-1 and Incretin-Based Pharmacotherapy
Authors
Angelo Avogaro
Saula Vigili de Kreutzenberg
Gian Paolo Fadini
Publication date
01-05-2014
Publisher
Springer US
Published in
Current Diabetes Reports / Issue 5/2014
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-014-0483-3

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