Skip to main content
Top
Published in: Current Diabetes Reports 1/2013

01-02-2013 | Hospital Management of Diabetes (G Umpierrez, Section Editor)

Management of Hyperglycemia During Enteral and Parenteral Nutrition Therapy

Authors: Aidar R. Gosmanov, Guillermo E. Umpierrez

Published in: Current Diabetes Reports | Issue 1/2013

Login to get access

Abstract

Hyperglycemia is a frequent complication of enteral and parenteral nutrition in hospitalized patients. Extensive evidence from observational studies indicates that the development of hyperglycemia during parenteral and enteral nutrition is associated with an increased risk of death and infectious complications. There are no specific guidelines recommending glycemic targets and effective strategies for the management of hyperglycemia during specialized nutritional support. Managing hyperglycemia in these patients should include optimization of carbohydrate content and administration of intravenous or subcutaneous insulin therapy. The administration of continuous insulin infusion and insulin addition to nutrition bag are efficient approaches to control hyperglycemia during parenteral nutrition. Subcutaneous administration of long-acting insulin with scheduled or corrective doses of short-acting insulin is superior to the sliding scale insulin strategy in patients receiving enteral feedings. Randomized controlled studies are needed to evaluate safe and effective therapeutic strategies for the management of hyperglycemia in patients receiving nutritional support.
Literature
1.
go back to reference •• Umpierrez GE, Hellman R, Korytkowski MT, et al. Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2012;97:16–38. These guidelnies represent the most up to date recommendations on management of hyperglycemia in hospitalized non-critically ill patients.PubMedCrossRef •• Umpierrez GE, Hellman R, Korytkowski MT, et al. Management of hyperglycemia in hospitalized patients in non-critical care setting: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2012;97:16–38. These guidelnies represent the most up to date recommendations on management of hyperglycemia in hospitalized non-critically ill patients.PubMedCrossRef
2.
go back to reference Cook CB, Kongable GL, Potter DJ, et al. Inpatient glucose control: a glycemic survey of 126 U.S. hospitals. J Hospital Med. 2009;4:E7–E14.CrossRef Cook CB, Kongable GL, Potter DJ, et al. Inpatient glucose control: a glycemic survey of 126 U.S. hospitals. J Hospital Med. 2009;4:E7–E14.CrossRef
3.
go back to reference Umpierrez GE, Isaacs SD, Bazargan N, et al. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab. 2002;87:978–82.PubMedCrossRef Umpierrez GE, Isaacs SD, Bazargan N, et al. Hyperglycemia: an independent marker of in-hospital mortality in patients with undiagnosed diabetes. J Clin Endocrinol Metab. 2002;87:978–82.PubMedCrossRef
4.
go back to reference Jiang HJ, Stryer D, Friedman B, Andrews R. Multiple hospitalizations for patients with diabetes. Diabetes Care. 2003;26:1421–6.PubMedCrossRef Jiang HJ, Stryer D, Friedman B, Andrews R. Multiple hospitalizations for patients with diabetes. Diabetes Care. 2003;26:1421–6.PubMedCrossRef
5.
go back to reference Pleva M, Mirtallo JM, Steinberg SM. Hyperglycemic events in non-intensive care unit patients receiving parenteral nutrition. Nutr Clin Pract. 2009;24:626–34.PubMedCrossRef Pleva M, Mirtallo JM, Steinberg SM. Hyperglycemic events in non-intensive care unit patients receiving parenteral nutrition. Nutr Clin Pract. 2009;24:626–34.PubMedCrossRef
6.
go back to reference Rosmarin DK, Wardlaw GM, Mirtallo J. Hyperglycemia associated with high, continuous infusion rates of total parenteral nutrition dextrose. Nutr Clin Pract. 1996;11:151–6.PubMedCrossRef Rosmarin DK, Wardlaw GM, Mirtallo J. Hyperglycemia associated with high, continuous infusion rates of total parenteral nutrition dextrose. Nutr Clin Pract. 1996;11:151–6.PubMedCrossRef
7.
go back to reference Arinzon Z, Shabat S, Shuval I, et al. Prevalence of diabetes mellitus in elderly patients received enteral nutrition long-term care service. Arch Gerontol Geriatr. 2008;47:383–93.PubMedCrossRef Arinzon Z, Shabat S, Shuval I, et al. Prevalence of diabetes mellitus in elderly patients received enteral nutrition long-term care service. Arch Gerontol Geriatr. 2008;47:383–93.PubMedCrossRef
8.
go back to reference Pancorbo-Hidalgo PL, Garcia-Fernandez FP, Ramirez-Perez C. Complications associated with enteral nutrition by nasogastric tube in an internal medicine unit. J Clin Nurs. 2001;10:482–90.PubMedCrossRef Pancorbo-Hidalgo PL, Garcia-Fernandez FP, Ramirez-Perez C. Complications associated with enteral nutrition by nasogastric tube in an internal medicine unit. J Clin Nurs. 2001;10:482–90.PubMedCrossRef
9.
go back to reference Baum D, Porte Jr D. Stress hyperglycemia and the adrenergic regulation of pancreatic hormones in hypoxia. Metabolism. 1980;29:1176–85.PubMedCrossRef Baum D, Porte Jr D. Stress hyperglycemia and the adrenergic regulation of pancreatic hormones in hypoxia. Metabolism. 1980;29:1176–85.PubMedCrossRef
10.
go back to reference Ortiz-Alonso FJ, Herman WH, Zobel DL, et al. Effect of epinephrine on pancreatic beta-cell and alpha-cell function in patients with NIDDM. Diabetes. 1991;40:1194–202.PubMedCrossRef Ortiz-Alonso FJ, Herman WH, Zobel DL, et al. Effect of epinephrine on pancreatic beta-cell and alpha-cell function in patients with NIDDM. Diabetes. 1991;40:1194–202.PubMedCrossRef
11.
12.
go back to reference Gosmanov AR, Umpierrez GE. Medical nutrition therapy in hospitalized patients with diabetes. Curr Diab Rep. 2012;12:93–100.PubMedCrossRef Gosmanov AR, Umpierrez GE. Medical nutrition therapy in hospitalized patients with diabetes. Curr Diab Rep. 2012;12:93–100.PubMedCrossRef
13.
go back to reference McCowen KC, Bistrian BR. Hyperglycemia and nutrition support: theory and practice. Nutr Clin Pract. 2004;19:235–44.PubMedCrossRef McCowen KC, Bistrian BR. Hyperglycemia and nutrition support: theory and practice. Nutr Clin Pract. 2004;19:235–44.PubMedCrossRef
14.
go back to reference McCowen KC, Malhotra A, Bistrian BR. Stress-induced hyperglycemia. Crit Care Clin. 2001;17:107–24.PubMedCrossRef McCowen KC, Malhotra A, Bistrian BR. Stress-induced hyperglycemia. Crit Care Clin. 2001;17:107–24.PubMedCrossRef
15.
go back to reference Alibegovic AC, Hojbjerre L, Sonne MP, et al. Impact of 9 days of bed rest on hepatic and peripheral insulin action, insulin secretion, and whole-body lipolysis in healthy young male offspring of patients with type 2 diabetes. Diabetes. 2009;58:2749–56.PubMedCrossRef Alibegovic AC, Hojbjerre L, Sonne MP, et al. Impact of 9 days of bed rest on hepatic and peripheral insulin action, insulin secretion, and whole-body lipolysis in healthy young male offspring of patients with type 2 diabetes. Diabetes. 2009;58:2749–56.PubMedCrossRef
16.
go back to reference Bienso RS, Ringholm S, Kiilerich K, et al. GLUT4 and Glycogen Synthase are key players in bed rest-induced insulin resistance. Diabetes. 2012;61:1090–9.PubMedCrossRef Bienso RS, Ringholm S, Kiilerich K, et al. GLUT4 and Glycogen Synthase are key players in bed rest-induced insulin resistance. Diabetes. 2012;61:1090–9.PubMedCrossRef
17.
go back to reference Ljungqvist O. Jonathan E. Rhoads Lecture 2011: insulin resistance and enhanced recovery after surgery. JPEN. J Parenter Enteral Nutr. 2012;36:389–98. Ljungqvist O. Jonathan E. Rhoads Lecture 2011: insulin resistance and enhanced recovery after surgery. JPEN. J Parenter Enteral Nutr. 2012;36:389–98.
18.
go back to reference Preiser JC. Glycemic control and nutrition. JPEN. Journal of Parenteral and Enteral. Nutrition. 2011;35:671–2. Preiser JC. Glycemic control and nutrition. JPEN. Journal of Parenteral and Enteral. Nutrition. 2011;35:671–2.
19.
go back to reference Valero MA, Leon-Sanz M, Escobar I, et al. Evaluation of nonglucose carbohydrates in parenteral nutrition for diabetic patients. Eur J Clin Nutr. 2001;55:1111–6.PubMedCrossRef Valero MA, Leon-Sanz M, Escobar I, et al. Evaluation of nonglucose carbohydrates in parenteral nutrition for diabetic patients. Eur J Clin Nutr. 2001;55:1111–6.PubMedCrossRef
20.
go back to reference Furnary AP, Zerr KJ, Grunkemeier GL, Starr A. Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures. Ann Thorac Surg. 1999;67:352–60. discussion 360–352.PubMedCrossRef Furnary AP, Zerr KJ, Grunkemeier GL, Starr A. Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures. Ann Thorac Surg. 1999;67:352–60. discussion 360–352.PubMedCrossRef
21.
go back to reference van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001;345:1359–67.PubMedCrossRef van den Berghe G, Wouters P, Weekers F, et al. Intensive insulin therapy in critically ill patients. N Engl J Med. 2001;345:1359–67.PubMedCrossRef
22.
go back to reference Umpierrez GE, Smiley D, Jacobs S, et al. Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes undergoing general surgery (RABBIT 2 surgery). Diabetes Care. 2011;34:256–61.PubMedCrossRef Umpierrez GE, Smiley D, Jacobs S, et al. Randomized study of basal-bolus insulin therapy in the inpatient management of patients with type 2 diabetes undergoing general surgery (RABBIT 2 surgery). Diabetes Care. 2011;34:256–61.PubMedCrossRef
23.
go back to reference Cheung NW, Napier B, Zaccaria C, Fletcher JP. Hyperglycemia is associated with adverse outcomes in patients receiving total parenteral nutrition. Diabetes Care. 2005;28:2367–71.PubMedCrossRef Cheung NW, Napier B, Zaccaria C, Fletcher JP. Hyperglycemia is associated with adverse outcomes in patients receiving total parenteral nutrition. Diabetes Care. 2005;28:2367–71.PubMedCrossRef
24.
go back to reference Clement S, Braithwaite SS, Magee MF, et al. Management of diabetes and hyperglycemia in hospitals. Diabetes Care. 2004;27:553–91.PubMedCrossRef Clement S, Braithwaite SS, Magee MF, et al. Management of diabetes and hyperglycemia in hospitals. Diabetes Care. 2004;27:553–91.PubMedCrossRef
25.
go back to reference •• Korytkowski MT, Salata RJ, Koerbel GL, et al. Insulin therapy and glycemic control in hospitalized patients with diabetes during enteral nutrition therapy: a randomized controlled clinical trial. Diabetes Care. 2009;32:594–6. The only randomized controlled trial comparing different insulin regimens in managing hyperglycemia in patients receiving enteral nutrition therapy.PubMedCrossRef •• Korytkowski MT, Salata RJ, Koerbel GL, et al. Insulin therapy and glycemic control in hospitalized patients with diabetes during enteral nutrition therapy: a randomized controlled clinical trial. Diabetes Care. 2009;32:594–6. The only randomized controlled trial comparing different insulin regimens in managing hyperglycemia in patients receiving enteral nutrition therapy.PubMedCrossRef
26.
go back to reference • Ziegler TR. Parenteral nutrition in the critically ill patient. N Engl J Med. 2009;361:1088–97. State-of-the-art review article describing current evidence for the use of TPN in the hospitalized patients.PubMedCrossRef • Ziegler TR. Parenteral nutrition in the critically ill patient. N Engl J Med. 2009;361:1088–97. State-of-the-art review article describing current evidence for the use of TPN in the hospitalized patients.PubMedCrossRef
27.
go back to reference Pasquel FJ, Spiegelman R, McCauley M, et al. Hyperglycemia during total parenteral nutrition: an important marker of poor outcome and mortality in hospitalized patients. Diabetes Care. 2010;33:739–41.PubMedCrossRef Pasquel FJ, Spiegelman R, McCauley M, et al. Hyperglycemia during total parenteral nutrition: an important marker of poor outcome and mortality in hospitalized patients. Diabetes Care. 2010;33:739–41.PubMedCrossRef
28.
go back to reference Moghissi ES, Korytkowski MT, DiNardo M, et al. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Endocr Pract. 2009;15:353–69.PubMedCrossRef Moghissi ES, Korytkowski MT, DiNardo M, et al. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Endocr Pract. 2009;15:353–69.PubMedCrossRef
29.
go back to reference Mesotten D, Van den Berghe G. Glycemic targets and approaches to management of the patient with critical illness. Curr Diab Rep. 2012;12:101–7.PubMedCrossRef Mesotten D, Van den Berghe G. Glycemic targets and approaches to management of the patient with critical illness. Curr Diab Rep. 2012;12:101–7.PubMedCrossRef
30.
go back to reference • Marik PE, Preiser JC. Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis. Chest. 2010;137:544–51. This meta-analysis suggests that glycemic targets for the patients in ICU receiving parenteral nutrition can be lower than in other crictically ill patients.PubMedCrossRef • Marik PE, Preiser JC. Toward understanding tight glycemic control in the ICU: a systematic review and metaanalysis. Chest. 2010;137:544–51. This meta-analysis suggests that glycemic targets for the patients in ICU receiving parenteral nutrition can be lower than in other crictically ill patients.PubMedCrossRef
31.
go back to reference Sarkisian S, Fenton TR, Shaheen AA. Raman M [Parenteral nutrition-associated hyperglycemia in noncritically ill inpatients is associated with higher mortality. Canadian journal of gastroenterology]. Journal Canadien de Gastroenterologie. 2010;24:453–7.PubMed Sarkisian S, Fenton TR, Shaheen AA. Raman M [Parenteral nutrition-associated hyperglycemia in noncritically ill inpatients is associated with higher mortality. Canadian journal of gastroenterology]. Journal Canadien de Gastroenterologie. 2010;24:453–7.PubMed
32.
go back to reference Lin LY, Lin HC, Lee PC, et al. Hyperglycemia correlates with outcomes in patients receiving total parenteral nutrition. Am J Med Sci. 2007;333:261–5.PubMedCrossRef Lin LY, Lin HC, Lee PC, et al. Hyperglycemia correlates with outcomes in patients receiving total parenteral nutrition. Am J Med Sci. 2007;333:261–5.PubMedCrossRef
33.
go back to reference Van den Berghe G, Wilmer A, Milants I, et al. Intensive insulin therapy in mixed medical/surgical intensive care units: benefit vs harm. Diabetes. 2006;55:3151–9.PubMedCrossRef Van den Berghe G, Wilmer A, Milants I, et al. Intensive insulin therapy in mixed medical/surgical intensive care units: benefit vs harm. Diabetes. 2006;55:3151–9.PubMedCrossRef
34.
go back to reference Cresci G. Targeting the use of specialized nutritional formulas in surgery and critical care. JPEN; J Parenter Enteral Nutr. 2005;29:S92–5.PubMedCrossRef Cresci G. Targeting the use of specialized nutritional formulas in surgery and critical care. JPEN; J Parenter Enteral Nutr. 2005;29:S92–5.PubMedCrossRef
35.
go back to reference McMahon MM, Rizza RA. Nutrition support in hospitalized patients with diabetes mellitus. Mayo Clin Proc. 1996;71:587–94.PubMedCrossRef McMahon MM, Rizza RA. Nutrition support in hospitalized patients with diabetes mellitus. Mayo Clin Proc. 1996;71:587–94.PubMedCrossRef
36.
go back to reference Bantle JP, Wylie-Rosett J, Albright AL, et al. Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care. 2008;31 Suppl 1:S61–78.PubMed Bantle JP, Wylie-Rosett J, Albright AL, et al. Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care. 2008;31 Suppl 1:S61–78.PubMed
37.
go back to reference McClave SA, Martindale RG, Vanek VW, et al. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN; J Parenter Enteral Nutr. 2009;33:277–316.PubMedCrossRef McClave SA, Martindale RG, Vanek VW, et al. Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient: Society of Critical Care Medicine (SCCM) and American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.). JPEN; J Parenter Enteral Nutr. 2009;33:277–316.PubMedCrossRef
38.
39.
go back to reference Heyland DK, Montalvo M, MacDonald S, et al. Total parenteral nutrition in the surgical patient: a meta-analysis. Can J Surg. 2001;44:102–11.PubMed Heyland DK, Montalvo M, MacDonald S, et al. Total parenteral nutrition in the surgical patient: a meta-analysis. Can J Surg. 2001;44:102–11.PubMed
40.
go back to reference Bellantone R, Doglietto GB, Bossola M, et al. Preoperative parenteral nutrition in the high risk surgical patient. JPEN; J Parenter Enteral Nutr. 1988;12:195–7.PubMedCrossRef Bellantone R, Doglietto GB, Bossola M, et al. Preoperative parenteral nutrition in the high risk surgical patient. JPEN; J Parenter Enteral Nutr. 1988;12:195–7.PubMedCrossRef
41.
go back to reference Kreymann KG, Berger MM, Deutz NE, et al. ESPEN Guidelines on enteral nutrition: intensive care. Clin Nutr. 2006;25:210–23.PubMedCrossRef Kreymann KG, Berger MM, Deutz NE, et al. ESPEN Guidelines on enteral nutrition: intensive care. Clin Nutr. 2006;25:210–23.PubMedCrossRef
42.
go back to reference Florian JP, Pawelczyk JA. Non-esterified fatty acids increase arterial pressure via central sympathetic activation in humans. Clin Sci. 2010;118:61–9.CrossRef Florian JP, Pawelczyk JA. Non-esterified fatty acids increase arterial pressure via central sympathetic activation in humans. Clin Sci. 2010;118:61–9.CrossRef
43.
go back to reference Craig LD, Nicholson S, Silverstone FA, Kennedy RD. Use of a reduced-carbohydrate, modified-fat enteral formula for improving metabolic control and clinical outcomes in long-term care residents with type 2 diabetes: results of a pilot trial. Nutrition. 1998;14:529–34.PubMedCrossRef Craig LD, Nicholson S, Silverstone FA, Kennedy RD. Use of a reduced-carbohydrate, modified-fat enteral formula for improving metabolic control and clinical outcomes in long-term care residents with type 2 diabetes: results of a pilot trial. Nutrition. 1998;14:529–34.PubMedCrossRef
44.
go back to reference Leon-Sanz M, Garcia-Luna PP, Sanz-Paris A, et al. Glycemic and lipid control in hospitalized type 2 diabetic patients: evaluation of 2 enteral nutrition formulas (low carbohydrate-high monounsaturated fat vs high carbohydrate). JPEN; J Parenter Enteral Nutr. 2005;29:21–9.PubMedCrossRef Leon-Sanz M, Garcia-Luna PP, Sanz-Paris A, et al. Glycemic and lipid control in hospitalized type 2 diabetic patients: evaluation of 2 enteral nutrition formulas (low carbohydrate-high monounsaturated fat vs high carbohydrate). JPEN; J Parenter Enteral Nutr. 2005;29:21–9.PubMedCrossRef
45.
go back to reference Elia M, Ceriello A, Laube H, et al. Enteral nutritional support and use of diabetes-specific formulas for patients with diabetes: a systematic review and meta-analysis. Diabetes Care. 2005;28:2267–79.PubMedCrossRef Elia M, Ceriello A, Laube H, et al. Enteral nutritional support and use of diabetes-specific formulas for patients with diabetes: a systematic review and meta-analysis. Diabetes Care. 2005;28:2267–79.PubMedCrossRef
46.
go back to reference Alish CJ, Garvey WT, Maki KC, et al. A diabetes-specific enteral formula improves glycemic variability in patients with type 2 diabetes. Diabetes Technol Ther. 2010;12:419–25.PubMedCrossRef Alish CJ, Garvey WT, Maki KC, et al. A diabetes-specific enteral formula improves glycemic variability in patients with type 2 diabetes. Diabetes Technol Ther. 2010;12:419–25.PubMedCrossRef
47.
go back to reference Vaisman N, Lansink M, Rouws CH, et al. Tube feeding with a diabetes-specific feed for 12 weeks improves glycaemic control in type 2 diabetes patients. Clin Nutr. 2009;28:549–55.PubMedCrossRef Vaisman N, Lansink M, Rouws CH, et al. Tube feeding with a diabetes-specific feed for 12 weeks improves glycaemic control in type 2 diabetes patients. Clin Nutr. 2009;28:549–55.PubMedCrossRef
48.
go back to reference Pohl M, Mayr P, Mertl-Roetzer M, et al. Glycemic control in patients with type 2 diabetes mellitus with a disease-specific enteral formula: stage II of a randomized, controlled multicenter trial. JPEN; J Parenter Enteral Nutr. 2009;33:37–49.PubMedCrossRef Pohl M, Mayr P, Mertl-Roetzer M, et al. Glycemic control in patients with type 2 diabetes mellitus with a disease-specific enteral formula: stage II of a randomized, controlled multicenter trial. JPEN; J Parenter Enteral Nutr. 2009;33:37–49.PubMedCrossRef
49.
go back to reference Pohl M, Mayr P, Mertl-Roetzer M, et al. Glycaemic control in type II diabetic tube-fed patients with a new enteral formula low in carbohydrates and high in monounsaturated fatty acids: a randomised controlled trial. Eur J Clin Nutr. 2005;59:1221–32.PubMedCrossRef Pohl M, Mayr P, Mertl-Roetzer M, et al. Glycaemic control in type II diabetic tube-fed patients with a new enteral formula low in carbohydrates and high in monounsaturated fatty acids: a randomised controlled trial. Eur J Clin Nutr. 2005;59:1221–32.PubMedCrossRef
50.
go back to reference Yokoyama J, Someya Y, Yoshihara R, Ishii H. Effects of high-monounsaturated fatty acid enteral formula vs high-carbohydrate enteral formula on plasma glucose concentration and insulin secretion in healthy individuals and diabetic patients. J Int Med Res. 2008;36:137–46.PubMed Yokoyama J, Someya Y, Yoshihara R, Ishii H. Effects of high-monounsaturated fatty acid enteral formula vs high-carbohydrate enteral formula on plasma glucose concentration and insulin secretion in healthy individuals and diabetic patients. J Int Med Res. 2008;36:137–46.PubMed
51.
go back to reference Charney P, Hertzler SR. Management of blood glucose and diabetes in the critically ill patient receiving enteral feeding. Nutr Clin Pract. 2004;19:129–36.PubMedCrossRef Charney P, Hertzler SR. Management of blood glucose and diabetes in the critically ill patient receiving enteral feeding. Nutr Clin Pract. 2004;19:129–36.PubMedCrossRef
52.
go back to reference Umpierrez GE. Basal vs sliding-scale regular insulin in hospitalized patients with hyperglycemia during enteral nutrition therapy. Diabetes Care. 2009;32:751–3.PubMedCrossRef Umpierrez GE. Basal vs sliding-scale regular insulin in hospitalized patients with hyperglycemia during enteral nutrition therapy. Diabetes Care. 2009;32:751–3.PubMedCrossRef
53.
go back to reference Fatati G, Mirri E, Del Tosto S, et al. Use of insulin glargine in patients with hyperglycaemia receiving artificial nutrition. Acta Diabetol. 2005;42:182–6.PubMedCrossRef Fatati G, Mirri E, Del Tosto S, et al. Use of insulin glargine in patients with hyperglycaemia receiving artificial nutrition. Acta Diabetol. 2005;42:182–6.PubMedCrossRef
54.
go back to reference Cook A, Burkitt D, McDonald L, Sublett L. Evaluation of glycemic control using NPH insulin sliding scale vs insulin aspart sliding scale in continuously tube-fed patients. Nutrition in Clinical Practice: official publication of the American Society for Parenteral and Enteral Nutrition. 2009;24:718–22.CrossRef Cook A, Burkitt D, McDonald L, Sublett L. Evaluation of glycemic control using NPH insulin sliding scale vs insulin aspart sliding scale in continuously tube-fed patients. Nutrition in Clinical Practice: official publication of the American Society for Parenteral and Enteral Nutrition. 2009;24:718–22.CrossRef
55.
go back to reference Hsia E, Seggelke SA, Gibbs J, et al. Comparison of 70/30 biphasic insulin with glargine/lispro regimen in non-critically ill diabetic patients on continuous enteral nutrition therapy. Nutrition in Clinical Practice: official publication of the American Society for Parenteral and Enteral Nutrition. 2011;26:714–7.CrossRef Hsia E, Seggelke SA, Gibbs J, et al. Comparison of 70/30 biphasic insulin with glargine/lispro regimen in non-critically ill diabetic patients on continuous enteral nutrition therapy. Nutrition in Clinical Practice: official publication of the American Society for Parenteral and Enteral Nutrition. 2011;26:714–7.CrossRef
56.
go back to reference Umpierrez GE, Jones S, Smiley D, et al. Insulin analogs vs human insulin in the treatment of patients with diabetic ketoacidosis: a randomized controlled trial. Diabetes Care. 2009;32:1164–9.PubMedCrossRef Umpierrez GE, Jones S, Smiley D, et al. Insulin analogs vs human insulin in the treatment of patients with diabetic ketoacidosis: a randomized controlled trial. Diabetes Care. 2009;32:1164–9.PubMedCrossRef
57.
go back to reference Detsky AS, Baker JP, O’Rourke K, Goel V. Perioperative parenteral nutrition: a meta-analysis. Ann Intern Med. 1987;107:195–203.PubMed Detsky AS, Baker JP, O’Rourke K, Goel V. Perioperative parenteral nutrition: a meta-analysis. Ann Intern Med. 1987;107:195–203.PubMed
58.
go back to reference Muller JM, Brenner U, Dienst C, Pichlmaier H. Preoperative parenteral feeding in patients with gastrointestinal carcinoma. Lancet. 1982;1:68–71.PubMedCrossRef Muller JM, Brenner U, Dienst C, Pichlmaier H. Preoperative parenteral feeding in patients with gastrointestinal carcinoma. Lancet. 1982;1:68–71.PubMedCrossRef
59.
go back to reference Quigley EM, Marsh MN, Shaffer JL, Markin RS. Hepatobiliary complications of total parenteral nutrition. Gastroenterology. 1993;104:286–301.PubMed Quigley EM, Marsh MN, Shaffer JL, Markin RS. Hepatobiliary complications of total parenteral nutrition. Gastroenterology. 1993;104:286–301.PubMed
60.
go back to reference Schutz Y, Thiebaud D, Acheson KJ, et al. Thermogenesis induced by five different intravenous glucose/insulin infusions in healthy young men. Clin Nutr. 1983;2:93–6.PubMedCrossRef Schutz Y, Thiebaud D, Acheson KJ, et al. Thermogenesis induced by five different intravenous glucose/insulin infusions in healthy young men. Clin Nutr. 1983;2:93–6.PubMedCrossRef
61.
go back to reference Askanazi J, Weissman C, Rosenbaum SH, et al. Nutrition and the respiratory system. Crit Care Med. 1982;10:163–72.PubMedCrossRef Askanazi J, Weissman C, Rosenbaum SH, et al. Nutrition and the respiratory system. Crit Care Med. 1982;10:163–72.PubMedCrossRef
62.
go back to reference Singer P, Berger MM, Van den Berghe G, et al. ESPEN Guidelines on Parenteral Nutrition: intensive care. Clin Nutr. 2009;28:387–400.PubMedCrossRef Singer P, Berger MM, Van den Berghe G, et al. ESPEN Guidelines on Parenteral Nutrition: intensive care. Clin Nutr. 2009;28:387–400.PubMedCrossRef
63.
go back to reference Via MA, Mechanick JI. Inpatient enteral and parental nutrition for patients with diabetes. Curr Diab Rep. 2011;11:99–105.PubMedCrossRef Via MA, Mechanick JI. Inpatient enteral and parental nutrition for patients with diabetes. Curr Diab Rep. 2011;11:99–105.PubMedCrossRef
64.
go back to reference Ahrens CL, Barletta JF, Kanji S, et al. Effect of low-calorie parenteral nutrition on the incidence and severity of hyperglycemia in surgical patients: a randomized, controlled trial. Crit Care Med. 2005;33:2507–12.PubMedCrossRef Ahrens CL, Barletta JF, Kanji S, et al. Effect of low-calorie parenteral nutrition on the incidence and severity of hyperglycemia in surgical patients: a randomized, controlled trial. Crit Care Med. 2005;33:2507–12.PubMedCrossRef
65.
go back to reference Lee H, Koh SO, Park MS. Higher dextrose delivery via TPN related to the development of hyperglycemia in nondiabetic critically ill patients. Nutr Res Pract. 2011;5:450–4.PubMedCrossRef Lee H, Koh SO, Park MS. Higher dextrose delivery via TPN related to the development of hyperglycemia in nondiabetic critically ill patients. Nutr Res Pract. 2011;5:450–4.PubMedCrossRef
66.
go back to reference •• Casaer MP, Mesotten D, Hermans G, et al. Early vs late parenteral nutrition in critically ill adults. N Engl J Med. 2011;365:506–17. The results of this prospective randomized trial demonstrate new standards of nutrition initiation in hospitalized patients requiring parenteral nutrition.PubMedCrossRef •• Casaer MP, Mesotten D, Hermans G, et al. Early vs late parenteral nutrition in critically ill adults. N Engl J Med. 2011;365:506–17. The results of this prospective randomized trial demonstrate new standards of nutrition initiation in hospitalized patients requiring parenteral nutrition.PubMedCrossRef
67.
go back to reference Lidder P, Flanagan D, Fleming S, et al. Combining enteral with parenteral nutrition to improve postoperative glucose control. Br J Nutr. 2010;103:1635–41.PubMedCrossRef Lidder P, Flanagan D, Fleming S, et al. Combining enteral with parenteral nutrition to improve postoperative glucose control. Br J Nutr. 2010;103:1635–41.PubMedCrossRef
68.
69.
go back to reference Yaqoob P. Monounsaturated fatty acids in parenteral nutrition; evaluation of risks and benefits. Br J Nutr. 2005;94:867–8.PubMedCrossRef Yaqoob P. Monounsaturated fatty acids in parenteral nutrition; evaluation of risks and benefits. Br J Nutr. 2005;94:867–8.PubMedCrossRef
70.
go back to reference Buenestado A, Cortijo J, Sanz MJ, et al. Olive oil-based lipid emulsion’s neutral effects on neutrophil functions and leukocyte-endothelial cell interactions. JPEN; J Parenter Enteral Nutr. 2006;30:286–96.PubMedCrossRef Buenestado A, Cortijo J, Sanz MJ, et al. Olive oil-based lipid emulsion’s neutral effects on neutrophil functions and leukocyte-endothelial cell interactions. JPEN; J Parenter Enteral Nutr. 2006;30:286–96.PubMedCrossRef
71.
go back to reference Garcia-de-Lorenzo A, Denia R, Atlan P, et al. Parenteral nutrition providing a restricted amount of linoleic acid in severely burned patients: a randomized double-blind study of an olive oil-based lipid emulsion vs medium/long-chain triacylglycerols. Br J Nutr. 2005;94:221–30.PubMedCrossRef Garcia-de-Lorenzo A, Denia R, Atlan P, et al. Parenteral nutrition providing a restricted amount of linoleic acid in severely burned patients: a randomized double-blind study of an olive oil-based lipid emulsion vs medium/long-chain triacylglycerols. Br J Nutr. 2005;94:221–30.PubMedCrossRef
73.
go back to reference Siqueira J, Smiley D, Newton C, et al. Substitution of standard soybean oil with olive oil-based lipid emulsion in parenteral nutrition: comparison of vascular, metabolic, and inflammatory effects. J Clin Endocrinol Metab. 2011;96:3207–16.PubMedCrossRef Siqueira J, Smiley D, Newton C, et al. Substitution of standard soybean oil with olive oil-based lipid emulsion in parenteral nutrition: comparison of vascular, metabolic, and inflammatory effects. J Clin Endocrinol Metab. 2011;96:3207–16.PubMedCrossRef
74.
go back to reference •• Umpierrez GE, Spiegelman R, Zhao V, et al. A double-blind, randomized clinical trial comparing soybean oil-based vs olive oil-based lipid emulsions in adult medical-surgical intensive care unit patients requiring parenteral nutrition. Crit Care Med. 2012;40:1792–8. This is the only trial that compared clinical outcomes betwenn ICU patients receiving soybean oil-based and olive oil-based parenteral nutrition.PubMedCrossRef •• Umpierrez GE, Spiegelman R, Zhao V, et al. A double-blind, randomized clinical trial comparing soybean oil-based vs olive oil-based lipid emulsions in adult medical-surgical intensive care unit patients requiring parenteral nutrition. Crit Care Med. 2012;40:1792–8. This is the only trial that compared clinical outcomes betwenn ICU patients receiving soybean oil-based and olive oil-based parenteral nutrition.PubMedCrossRef
75.
go back to reference Opara EC, Petro A, Tevrizian A, et al. L-glutamine supplementation of a high fat diet reduces body weight and attenuates hyperglycemia and hyperinsulinemia in C57BL/6J mice. J Nutr. 1996;126:273–9.PubMed Opara EC, Petro A, Tevrizian A, et al. L-glutamine supplementation of a high fat diet reduces body weight and attenuates hyperglycemia and hyperinsulinemia in C57BL/6J mice. J Nutr. 1996;126:273–9.PubMed
76.
go back to reference Grau T, Bonet A, Minambres E, et al. The effect of L-alanyl-L-glutamine dipeptide supplemented total parenteral nutrition on infectious morbidity and insulin sensitivity in critically ill patients. Crit Care Med. 2011;39:1263–8.PubMedCrossRef Grau T, Bonet A, Minambres E, et al. The effect of L-alanyl-L-glutamine dipeptide supplemented total parenteral nutrition on infectious morbidity and insulin sensitivity in critically ill patients. Crit Care Med. 2011;39:1263–8.PubMedCrossRef
77.
go back to reference McMahon MM. Management of parenteral nutrition in acutely ill patients with hyperglycemia. Nutr Clin Pract. 2004;19:120–8.PubMedCrossRef McMahon MM. Management of parenteral nutrition in acutely ill patients with hyperglycemia. Nutr Clin Pract. 2004;19:120–8.PubMedCrossRef
78.
go back to reference Sajbel TA, Dutro MP, Radway PR. Use of separate insulin infusions with total parenteral nutrition. JPEN; J Parenter Enteral Nutr. 1987;11:97–9.PubMedCrossRef Sajbel TA, Dutro MP, Radway PR. Use of separate insulin infusions with total parenteral nutrition. JPEN; J Parenter Enteral Nutr. 1987;11:97–9.PubMedCrossRef
79.
go back to reference Hongsermeier T, Bistrian BR. Evaluation of a practical technique for determining insulin requirements in diabetic patients receiving total parenteral nutrition. JPEN; J Parenter Enteral Nutr. 1993;17:16–9.PubMedCrossRef Hongsermeier T, Bistrian BR. Evaluation of a practical technique for determining insulin requirements in diabetic patients receiving total parenteral nutrition. JPEN; J Parenter Enteral Nutr. 1993;17:16–9.PubMedCrossRef
80.
go back to reference Jakoby MG, Nannapaneni N. An insulin protocol for management of hyperglycemia in patients receiving parenteral nutrition is superior to ad hoc management. JPEN; J Parenter Enteral Nutr. 2012;36:183–8.PubMedCrossRef Jakoby MG, Nannapaneni N. An insulin protocol for management of hyperglycemia in patients receiving parenteral nutrition is superior to ad hoc management. JPEN; J Parenter Enteral Nutr. 2012;36:183–8.PubMedCrossRef
81.
go back to reference Bankhead R, Boullata J, Brantley S, et al. Enteral nutrition practice recommendations. JPEN; J Parenter Enteral Nutr. 2009;33:122–67.PubMedCrossRef Bankhead R, Boullata J, Brantley S, et al. Enteral nutrition practice recommendations. JPEN; J Parenter Enteral Nutr. 2009;33:122–67.PubMedCrossRef
Metadata
Title
Management of Hyperglycemia During Enteral and Parenteral Nutrition Therapy
Authors
Aidar R. Gosmanov
Guillermo E. Umpierrez
Publication date
01-02-2013
Publisher
Current Science Inc.
Published in
Current Diabetes Reports / Issue 1/2013
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-012-0335-y

Other articles of this Issue 1/2013

Current Diabetes Reports 1/2013 Go to the issue

Hospital Management of Diabetes (G Umpierrez, Section Editor)

Glycemic Management in Medical and Surgical Patients in the Non-ICU Setting

Hospital Management of Diabetes (G Umpierrez, Section Editor)

Adult Hyperglycemic Crisis: A Review and Perspective

Pediatric Type 2 Diabetes (PS Zeitler, Section Editor)

Progression of β-Cell Dysfunction in Obese Youth