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Current Diabetes Reports
Published in: Current Diabetes Reports 1/2012

01-02-2012 | Diabetes and Pregnancy (CJ Homko, Section Editor)

Gestational Diabetes: Implications for Cardiovascular Health

Authors: Shannon D. Sullivan, Jason G. Umans, Robert Ratner

Published in: Current Diabetes Reports | Issue 1/2012

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Abstract

Gestational diabetes mellitus (GDM) is a pregnancy complication that is becoming more prevalent with recent population trends in obesity and advancing maternal age. A diagnosis of GDM not only increases risk for maternal and fetal complications during pregnancy, but also significantly increases a woman’s risk of both type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) in the postpartum. Even women with milder forms of abnormal glucose homeostasis during pregnancy, specifically gestational impaired glucose tolerance, are at increased risk, justifying the recent recommendation to tighten the diagnostic criteria for GDM, thus implicating many more women. Risk factors that increase risk for future CVD among women with a history of GDM include postpartum progression to T2DM; metabolic syndrome; obesity; hypertension; and altered levels of circulating inflammatory markers, specifically, adiponectin, C-reactive protein, and tumor necrosis factor-α. Medical therapies such as metformin that prevent progression to T2DM may prove to be our primary defense against earlier CVD among women with GDM.
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Metadata
Title
Gestational Diabetes: Implications for Cardiovascular Health
Authors
Shannon D. Sullivan
Jason G. Umans
Robert Ratner
Publication date
01-02-2012
Publisher
Current Science Inc.
Published in
Current Diabetes Reports / Issue 1/2012
Print ISSN: 1534-4827
Electronic ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-011-0238-3

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