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Current Colorectal Cancer Reports
Published in: Current Colorectal Cancer Reports 6/2021

01-12-2021 | Regorafenib | Systemic Therapies in Colorectal Cancer (SM Kazmi, Section Editor)

Current Treatment Landscape for Third- or Later-Line Therapy in Metastatic Colorectal Cancer

Authors: Sadaf Qureshi, Lyudmyla Berim, Patrick M. Boland

Published in: Current Colorectal Cancer Reports | Issue 6/2021

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Abstract

Purpose of Review

The aim of this paper is to summarize the current treatment landscape in metastatic colorectal cancer, as well as those on the horizon in the third-line and beyond settings.

Recent Findings

Herein, recent data regarding TAS-102, regorafenib, and novel anti-angiogenic agents are described. Data on chemotherapy re-challenge and EGFR re-challenge is reviewed. A summary of data on the use of BRAF-targeted therapies, HER-2-targeted therapies, rare fusions (NTRK, RET), MET amplification, and KRAS G12C is included, as well as a brief review on the current role of immune checkpoint inhibitors in metastatic colorectal cancer.

Summary

Multiple new agents are on the horizon. There is increasing relevance of next generation sequencing to look for rare targets, and potentially to assess tumor mutational burden. ctDNA appears to be a valuable asset which may guide the use of therapies in the re-challenge setting.
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Metadata
Title
Current Treatment Landscape for Third- or Later-Line Therapy in Metastatic Colorectal Cancer
Authors
Sadaf Qureshi
Lyudmyla Berim
Patrick M. Boland
Publication date
01-12-2021
Publisher
Springer US
Published in
Current Colorectal Cancer Reports / Issue 6/2021
Print ISSN: 1556-3790
Electronic ISSN: 1556-3804
DOI
https://doi.org/10.1007/s11888-021-00469-4

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