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Current Cardiology Reports
Published in: Current Cardiology Reports 4/2022

01-04-2022 | Regenerative Medicine (SM Wu, Section Editor)

Mesenchymal Stromal Cell Exosomes in Cardiac Repair

Authors: Darukeshwara Joladarashi, Raj Kishore

Published in: Current Cardiology Reports | Issue 4/2022

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Abstract

Purpose of the Review

Mesenchymal stromal cells (MSCs) are considered an attractive option for cell-based therapy because of their immune-privileged phenotype and paracrine activity. Substantial preclinical evidence indicates that MSC exosomes recapitulate MSC cellular function in cardiac regeneration and repair. Therefore, in this review, we briefly discuss the latest research progress of MSC exosomes in cardiac repair and regeneration.

Recent Findings

The recent revolutionary advance in controlling the contents of the exosomes by manipulating parental cells through bioengineering methods to alter specific signaling pathways in ischemic myocardium has proven to be beneficial in the treatment of heart failure.

Summary

MSC Exosomes appear to be leading candidates to treat myocardial infarction and subsequent heart failure by carrying rich cargo from their parental cells. However, more clinical and pre-clinical studies on MSC exosomes will be required to confirm the beneficial effect to treat cardiovascular diseases
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Metadata
Title
Mesenchymal Stromal Cell Exosomes in Cardiac Repair
Authors
Darukeshwara Joladarashi
Raj Kishore
Publication date
01-04-2022
Publisher
Springer US
Published in
Current Cardiology Reports / Issue 4/2022
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI
https://doi.org/10.1007/s11886-022-01660-1

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