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01-05-2015 | Lipid Abnormalities and Cardiovascular Prevention (G De Backer, Section Editor)

Genetic Risk Factors and Mendelian Randomization in Cardiovascular Disease

Authors: Daniel I. Swerdlow, Aroon D. Hingorani, Steve E. Humphries

Published in: Current Cardiology Reports | Issue 5/2015

Abstract

Cardiovascular disease encompasses several diverse pathological states that place a heavy burden on individual and population health. The aetiological basis of many cardiovascular disorders is not fully understood. Growing knowledge of the genetic architecture underlying coronary heart disease, stroke, cardiac arrhythmias and peripheral vascular disease has confirmed some suspected causal pathways in these conditions but also uncovered many previously unknown mechanisms. Here, we consider the contribution of genetics to the understanding of cardiovascular disease risk. We evaluate the utility and relevance of findings from genome-wide association studies and explore the role that Mendelian randomisation has to play in exploiting these. Mendelian randomisation permits robust causal inference in an area of research where this has been hampered by bias and confounding in observational studies. In doing so, it provides evidence for causal processes in cardiovascular disease that could represent novel targets for much-needed new drugs for disease prevention and treatment.

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Title: Genetic Risk Factors and Mendelian Randomization in Cardiovascular Disease
Authors: Daniel I. Swerdlow
Aroon D. Hingorani
Steve E. Humphries
Publication date: 01-05-2015
Publisher: Springer US
Published in: Current Cardiology Reports / Issue 5/2015
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI: https://doi.org/10.1007/s11886-015-0584-x

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