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01-11-2010

New Advances in Noninvasive Imaging of the Carotid Artery: CIMT, Contrast-Enhanced Ultrasound, and Vasa Vasorum

Authors: Blai Coll, Vijay Nambi, Steven B. Feinstein

Published in: Current Cardiology Reports | Issue 6/2010

Abstract

Carotid ultrasound measurement of carotid intima-media thickness (CIMT) and detection of plaques is a useful method to better assess cardiovascular disease risk status, especially in those at intermediate risk. We discuss the use CIMT and other emerging techniques such as contrast-enhanced carotid ultrasound imaging in the evaluation of the carotid artery and its value in cardiovascular disease.

Hossain P, Kawar B, El Nahas M: Obesity and diabetes in the developing world--a growing challenge. N Engl J Med 2007, 356:213–215.

Gami AS, Witt BJ, Howard DE, et al.: Metabolic syndrome and risk of incident cardiovascular events and death: a systematic review and meta-analysis of longitudinal studies. J Am Coll Cardiol 2007, 49:403–414.CrossRefPubMed

Cowie CC, Rust KF, Byrd-Holt DD, et al.: Prevalence of diabetes and impaired fasting glucose in adults in the U.S. population: National Health And Nutrition Examination Survey 1999-2002. Diabetes Care 2006, 29:1263–1268.CrossRefPubMed

Lorenz MW, Markus HS, Bots ML, et al.: Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis. Circulation 2007, 115:459–467.CrossRefPubMed

Casscells W, Naghavi M, Willerson JT: Vulnerable atherosclerotic plaque: a multifocal disease. Circulation 2003, 107:2072–2075.CrossRefPubMed

Naghavi M, Falk E, Hecht HS, et al.: From vulnerable plaque to vulnerable patient--Part III: Executive summary of the Screening for Heart Attack Prevention and Education (SHAPE) Task Force report. Am J Cardiol 2006, 98:2H–15H.CrossRefPubMed

Khot UN, Khot MB, Bajzer CT, et al.: Prevalence of conventional risk factors in patients with coronary heart disease. JAMA 2003, 290:898–904.CrossRefPubMed

Espeland MA, O’Leary DH, Terry JG, et al.: Carotid intimal-media thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitors. Curr Control Trials Cardiovasc Med 2005, 6:3.CrossRefPubMed

Hurst RT, Ng DW, Kendall C, Khandheria B: Clinical use of carotid intima-media thickness: review of the literature. J Am Soc Echocardiogr 2007, 20:907–914.CrossRefPubMed

10.

Pignoli P, Longo T: Ultrasound evaluation of atherosclerosis. Methodological problems and technological developments. Eur Surg Res 1986, 18:238–253.CrossRefPubMed

11.

Wong M, Edelstein J, Wollman J, Bond MG: Ultrasonic-pathological comparison of the human arterial wall. Verification of intima-media thickness. Arterioscler Thromb 1993, 13:482–486.PubMed

12.

Gamble G, Beaumont B, Smith H, et al.: B-mode ultrasound images of the carotid artery wall: correlation of ultrasound with histological measurements. Atherosclerosis 1993, 102:163–173.CrossRefPubMed

13.

O’Leary DH, Polak JF, Kronmal RA, et al.: Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med 1999, 340:14–22.CrossRefPubMed

14.

Stein JH, Korcarz CE, Hurst RT, et al.: Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am Soc Echocardiogr 2008, 21:93–111; quiz 189–190.

15.

Postley JE, Perez A, Wong ND, Gardin JM: Prevalence and distribution of sub-clinical atherosclerosis by screening vascular ultrasound in low and intermediate risk adults: the New York physicians study. J Am Soc Echocardiogr 2009, 22:1145–1151.CrossRefPubMed

16.

Rundek T, Arif H, Boden-Albala B, et al.: Carotid plaque, a subclinical precursor of vascular events: the Northern Manhattan Study. Neurology 2008, 70:1200–1207.CrossRefPubMed

17.

Davidsson L, Fagerberg B, Bergstrom G, Schmidt C: Ultrasound-assessed plaque occurrence in the carotid and femoral arteries are independent predictors of cardiovascular events in middle-aged men during 10 years of follow-up. Atherosclerosis 2009, 209:469–473.CrossRefPubMed

18.

Griffin M, Nicolaides A, Tyllis T, et al.: Carotid and femoral arterial wall changes and the prevalence of clinical cardiovascular disease. Vasc Med 2009, 14:227–232.CrossRefPubMed

19.

Folsom AR, Kronmal RA, Detrano RC, et al.: Coronary artery calcification compared with carotid intima-media thickness in the prediction of cardiovascular disease incidence: the Multi-Ethnic Study of Atherosclerosis (MESA). Arch Intern Med 2008, 168:1333–1339.CrossRefPubMed

20.

• Nambi V, Chambless L, Folsom AR, et al.: Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk In Communities) study. J Am Coll Cardiol 2010, 55:1600–1607. This recent manuscript detailed 15-year cardiovascular outcome data for the cohort. The results provided evidence that the combined use of CIMT and carotid plaque serve as powerful predictors for cardiovascular outcomes. In fact, when these were used in tandem, the ability to reclassify “at risk” was statistically and clinically significantly improved over traditional risk factor utilization.CrossRefPubMed

21.

Macioch JE, Katsamakis CD, Robin J, et al.: Effect of contrast enhancement on measurement of carotid artery intimal medial thickness. Vasc Med 2004, 9:7–12.CrossRefPubMed

22.

Montauban van Swijndregt AD, De Lange EE, De Groot E, Ackerstaff RG: An in vivo evaluation of the reproducibility of intima-media thickness measurements of the carotid artery segments using B-mode ultrasound. Ultrasound Med Biol 1999, 25:323–330.

23.

Montauban van Swijndregt AD, The SH, Gussenhoven EJ, et al.: An in vitro evaluation of the line pattern of the near and far walls of carotid arteries using B-mode ultrasound. Ultrasound Med Biol 1996, 22:1007–1015.

24.

Feinstein SB: The powerful microbubble: from bench to bedside, from intravascular indicator to therapeutic delivery system, and beyond. Am J Physiol Heart Circ Physiol 2004, 287:H450–H457.CrossRefPubMed

25.

• Shah F, Balan P, Weinberg M, et al.: Contrast-enhanced ultrasound imaging of atherosclerotic carotid plaque neovascularization: a new surrogate marker of atherosclerosis? Vasc Med 2007, 12:291–297. This manuscript correlated and quantified the association of contrast-enhanced visualization of intraplaque vasa vasorum and histologic-based neovascularization. This histologic validation supported the earlier reported clinical observations on the subject of carotid artery angiogenesis.CrossRefPubMed

26.

Vicenzini E, Giannoni MF, Puccinelli F, et al.: Detection of carotid adventitial vasa vasorum and plaque vascularization with ultrasound cadence contrast pulse sequencing technique and echo-contrast agent. Stroke 2007, 38:2841–2843.CrossRefPubMed

27.

Coli S, Magnoni M, Sangiorgi G, et al.: Contrast-enhanced ultrasound imaging of intraplaque neovascularization in carotid arteries: correlation with histology and plaque echogenicity. J Am Coll Cardiol 2008, 52:223–230.CrossRefPubMed

28.

Xiong L, Deng YB, Zhu Y, et al.: Correlation of carotid plaque neovascularization detected by using contrast-enhanced US with clinical symptoms. Radiology 2009, 251:583–589.CrossRefPubMed

29.

Fleiner M, Kummer M, Mirlacher M, et al.: Arterial neovascularization and inflammation in vulnerable patients: early and late signs of symptomatic atherosclerosis. Circulation 2004, 110:2843–2850.CrossRefPubMed

30.

Moreno PR, Fuster V: New aspects in the pathogenesis of diabetic atherothrombosis. J Am Coll Cardiol 2004, 44:2293–2300.CrossRefPubMed

31.

Dunmore BJ, McCarthy MJ, Naylor AR, Brindle NP: Carotid plaque instability and ischemic symptoms are linked to immaturity of microvessels within plaques. J Vasc Surg 2007, 45:155–159.CrossRefPubMed

32.

Jeziorska M, Woolley DE: Neovascularization in early atherosclerotic lesions of human carotid arteries: its potential contribution to plaque development. Hum Pathol 1999, 30:919–925.CrossRefPubMed

33.

Shalhoub J, Owen DR, Gauthier T, et al.: The use of contrast enhanced ultrasound in carotid arterial disease. Eur J Vasc Endovasc Surg 2010, 39:381–387.CrossRefPubMed

34.

Barger AC, Beeuwkes R 3 rd, Lainey LL, Silverman KJ: Hypothesis: vasa vasorum and neovascularization of human coronary arteries. A possible role in the pathophysiology of atherosclerosis. N Engl J Med 1984, 310:175–177.CrossRefPubMed

35.

Kumamoto M, Nakashima Y, Sueishi K: Intimal neovascularization in human coronary atherosclerosis: its origin and pathophysiological significance. Hum Pathol 1995, 26:450–456.CrossRefPubMed

36.

Heistad DD, Armstrong ML: Blood flow through vasa vasorum of coronary arteries in atherosclerotic monkeys. Arteriosclerosis 1986, 6:326–331.PubMed

37.

Moulton KS: Plaque angiogenesis and atherosclerosis. Curr Atheroscler Rep 2001, 3:225–233.CrossRefPubMed

38.

Wilson SH, Herrmann J, Lerman LO, et al.: Simvastatin preserves the structure of coronary adventitial vasa vasorum in experimental hypercholesterolemia independent of lipid lowering. Circulation 2002, 105:415–418.CrossRefPubMed

39.

• Schinkel AF, Krueger CG, Tellez A, et al.: Contrast-enhanced ultrasound for imaging vasa vasorum: comparison with histopathology in a swine model of atherosclerosis. Eur J Echocardiogr 2010 Apr 12 [Epub ahead of print]. doi:10.1039/ejechocard/jeq048. In this recent publication, the authors provided a new experimental model for the in vivo assessment of atherosclerosis using the Rapacz familial hypercholesterolemic swine model.

40.

Ainsworth CD, Blake CC, Tamayo A, et al.: 3D ultrasound measurement of change in carotid plaque volume: a tool for rapid evaluation of new therapies. Stroke 2005, 36:1904–1909.CrossRefPubMed

41.

Shai I, Spence JD, Schwarzfuchs D, et al.: Dietary intervention to reverse carotid atherosclerosis. Circulation 2010, 121:1200–1208.CrossRefPubMed

Title: New Advances in Noninvasive Imaging of the Carotid Artery: CIMT, Contrast-Enhanced Ultrasound, and Vasa Vasorum
Authors: Blai Coll
Vijay Nambi
Steven B. Feinstein
Publication date: 01-11-2010
Publisher: Current Science Inc.
Published in: Current Cardiology Reports / Issue 6/2010
Print ISSN: 1523-3782
Electronic ISSN: 1534-3170
DOI: https://doi.org/10.1007/s11886-010-0139-0

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