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Current Bladder Dysfunction Reports
Published in: Current Bladder Dysfunction Reports 2/2019

01-06-2019 | Voiding Disorder | Voiding Dysfunction Evaluation (B Brucker and B Peyronnet, Section Editors)

Mathematical Modeling and Uroflow-Based Nomograms in Voiding Dysfunction Evaluation: Ready for Prime Time?

Authors: Françoise A. Valentini, Pierre P. Nelson

Published in: Current Bladder Dysfunction Reports | Issue 2/2019

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Abstract

Purpose of Review

In this review, we will describe the interest and role of mathematical modeling and uroflow-based nomograms in voiding dysfunction evaluation.

Recent Findings

Due to the time-consuming character of implementation and use, mathematical models are now used to build “numerized nomograms.” These have the advantage over nomograms to allow the study of systems with more than two parameters. While at early stages, assessment of bladder outlet obstruction using nomograms has been initiated in men, and recently, an interesting nomogram has been developed in women.

Summary

Mathematical modeling and uroflow-based nomograms in voiding dysfunction evaluation are an interesting field of research. Models need time, accuracy, and perseverance. Nomograms and numerized nomograms are easier to use. The number of proposed nomograms is growing. Today, the lack of external validation limits their use.
Literature
1.
Descartes R. La géométrie, livre premier. In: Imprimerie Ian Maire. Le discours de la méthode. Leyde; 1637.
2.
Hosein RA, Griffiths DJ. Computer simulation of the neural control of bladder and urethra. Neurourol Urodyn. 1990;9:601–18.CrossRef
3.
Bastiaanssen EHC, van Leeuwen JL, Vanderschoot J, Redert PA. A myocybernetic model of the lower urinary tract. J Theor Biol. 1996;178:113–33.CrossRefPubMed
4.
Hübener U, van Mastrigt R. Computer simulation of micturition. Urodinamica. 1994;4:81–90.
5.
van Duin F, Rosier PFWM, Rijkhoff NJM, van Kerrebroeck PEV, Debruyne FMJ, Wijkstra H. A computer model of the neural control of the lower urinary tract. Neurourol Urodyn. 1998;17:175–96.CrossRefPubMed
6.
Valentini FA, Besson GR, Nelson PP, Zimmern PE. A mathematical micturition model to restore simple flow recordings in healthy and symptomatic individuals and enhance uroflow interpretation. Neurourol Urodyn. 2000;19(2):153–76.CrossRefPubMed
7.
Porena M, Biscotto S, Costantini E, Mearini E, Verdini L. Perugia urodynamic method of analysis (PUMA): a new advanced method of urodynamic analysis applied clinically and compared with other advanced methods. Neurourol Urodyn. 2003;22:206–22.CrossRefPubMed
8.
Biscotto S, Costantini E, Rociola W, Mearini L, Bini V, Porena M. Cut-off values to define bladder outlet obstruction (BOO) in women. Neurourol Urodyn. 2004;23:488–9.
9.
Valentini FA, Zimmern PP, Besson GR, Nelson PP. Modelized analysis of pressure-flow studies of patients with lower urinary tract symptoms due to benign prostatic enlargement. Neurourol Urodyn. 2003;22:45–53.CrossRefPubMed
10.
Valentini FA, Besson G, Malavaud B, Nelson PP, Saby M-O. α-Blockers: study of their effectiveness on the mechanical consequences of benign prostatic hypertrophy (BPH) on bladder neck and prostatic urethra by means of a mathematical model. European Urol. 1996;30(Suppl):2: 97.
11.
Valentini FA, Besson G, Nelson PP. Modelized analysis of the effect of Tadenan (Pygeum africanum extract, PA) on the bladder of patients with benign prostatic hyperplasia (BPH): blind vs. open study of uroflows. 20th Annual Meeting S.U.F.U., Dallas TX (USA) 1 Mai 1999.
12.
Valentini F, Pigné A, Nelson P. Comparison at short follow-up of the changes in the voiding phase induced by sub-urethral tapes (TVT and TVT-O). ICS Meeting, Montréal (Canada). 2005 Non discussed poster #382.
13.
Valentini FA, Gilchrist A, Nelson PP, Zimmern PE. Anew index of voiding dysfunction in men with benign prostatic hyperplasia undergoing transurethral resection of the prostate adds superior information to the traditional maximum flow rate (Qmax). Curr Urol. 2011;5:151–7. https://​doi.​org/​10.​1159/​000327469.CrossRef
14.
Abrams PH, Griffiths DJ. The assessment of prostatic obstruction from urodynamic measurements and from residual urine. Br J Urol. 1979;51:129–34.CrossRefPubMed
15.
16.
Griffiths D, Höfner K, van Mastrigt R, Rollema HJ, Spangberg A, Gleason D. Standardization of terminology of lower urinary tract function: pressure-flow studies of voiding, urethral resistance and urethrl obstruction. Neurorurol Urodyn. 1997;16:1–18.CrossRef
17.
Schafer W. Principles and clinical application of advanced urodynamic analysis of voiding dysfunction. Urol Clin North Am. 1990;17:553–6.PubMed
18.
Schäfer W. Analysis of bladder outlet function with the linearized passive urethral resistance relation, linPURR, and a disease-specific approach for grading obstruction: from complex to simple. World J Urol. 1995;13:47–58.CrossRefPubMed
19.
Abrams P. Bladder outlet obstruction index, bladder contractility index and bladder voiding efficiency: three simple indices to define bladder voiding function. BJU Int. 1999;84:14–5.CrossRefPubMed
20.
Chassagne S, Bernier PA, Haab F, Roehrborn CG, Reisch JS, Zimmern PE. Proposed cutoff values to define bladder outlet obstruction in women. Urology. 1998;51:408–11.CrossRefPubMed
21.
Defreitas GA, Zimmern PE, Lemack GE, Shariat SF. Refining diagnosis of anatomic female bladder outlet obstruction: comparison of pressure-flow study parameters in clinically obstructed women with those of normal controls. Urology. 2004;64:675–9.CrossRefPubMed
22.
Blaivas JG, Groutz A. Bladder outlet obstruction nomogram for women with lower urinary tract symptonatology. Neurourol Urodyn. 2000;19:553–64.CrossRefPubMed
23.
Virseda Chamorro M, Salinas Casado J, AdotZurbano JM, Martin Garcia C. May the Blaivas and Groutz nomogram substitute videourodynamic studies in the diagnosis of female lower urinary tract obstruction? Arch Esp Urol. 2006;59:601–6.PubMed
24.
25.
Massolt ET, Groen J, Vierhout ME. Application of the Blaivas-Groutz bladder outlet obstruction nomogram in women with urinary incontinence. Neurourol Urodyn. 2005;24:237–42.CrossRefPubMed
26.
• Solomon E, Yasmin H, Duffy M, Rashid T, Akinluyl E, Greenwell TJ. Developping and validating a new nomogram for diagnosing bladder outlet obstruction in women. NeurourolUrodyn. 2018;37:368–78. https://​doi.​org/​10.​1002/​nau.​23307 A useful nomogram and index to assess the degree of BOO in women.CrossRef
27.
28.
Comiter CV, Sullivan MP, Schacterle RS, Yalla SV. Prediction of prostatic obstruction with a combination of isometric detrusor contraction pressure and maximum urinary flow rate. Urology. 1996;48:723–30.CrossRefPubMed
29.
Mc Rae LP, Bottacini MR, Gleason DM. Non invasive quantitative method for measuring isovolumetric bladder pressure and urethral resistance in the male: I. Experimental validation of the theory. Neurourol Urodyn. 1995;14:101–14.CrossRef
30.
Salinas J, Virseda M, Arredondo F. Validity of cuff-uroflow as a diagnostic technique for bladder outlet obstruction in males. Scand J Urol Nephrol 2003; 37 :316–321. DOI: 1080/00365590310001610.
31.
Schafer W, Kirschner-Hermans R, Jakse G. Non invasive pressure/flow measurement for precise grading of bladder outflow obstruction [abstract]. J Urol 1994; 151 (suppl.): 323A–condom.
32.
33.
34.
• van Mastrigt R, Boeve E, de Zeeuw S, Groen J. A new nomogram to noninvasively diagnose bladder outlet obstruction using condom catheter measurements. ICS meeting 2015 Montreal (Canada) e-poster #129. The more recent study on condom catheter.
35.
Huang Foen Chung JWNC, Bohnen AM, Pel JJM, Bosch JLHR, Niesing R, van Mastrigt R. Applicability and reproducibility of the condom catheter method for measuring the isovolumetric bladder pressure. Urology. 2004;63:56–60.CrossRefPubMed
36.
•• Malde S, Nambiar AK, Umbach R, Lam TB, Bach T, Bachmann A, et al. Systematic review of the performance of noninvasive tests in diagnosing bladder outlet obstruction in men with lower urinary tract symptoms. Eur Urol. 2017;71:391–402. 10.1016:j.eururo.2016.09.026 A review of the performance of noninvasive tests in diagnosing bladder outlet obstruction in men.
37.
Griffiths CJ, Harding C, Blake S, McIntosh S, Drinnan MJ, Robson WA, et al. A nomogram to classify men with lower urinary tract symptoms using urine flow and noninvasive measurement of bladder pressure. J Urol. 2005;174:1323–6.CrossRefPubMed
38.
39.
Finazzi Agrò E, Lamorte F, Patruno G, Bove P, Petta F, Topazio L, Di Santo A. Non invasive urodynamics: the penile cuff test in patients candidate to TURP (ICS #15 42nd Annual Meeting of the International-Continence-Society (ICS); 2012 Oct 15-19; Beijing, China. Bristol (UK): Hoboken: International-Continence-Society; Wiley-Blackwell; 2012. pp. 744–746.
40.
41.
42.
• Matulewicz RS, Hairston JC. The UroCuff test: a non-invasive alternative to pressure flow studies in adult males with lower urinary tract symptoms secondary to bladder outlet obstruction. Can J Urol. 2015;22:7896–901 A recent use of the Newcastle nomogram with a similar device.PubMed
43.
44.
•• Valentini FA, Nelson PP. Nomograms allowing evaluation of bladder outlet obstruction (BOO) in men from free uroflows (FF).J Urol 2015; 193 (4) suppl: 1105. Evaluation of BOO in men from free uroflows using the D index.
45.
• Valentini FA, Nelson PP, Zimmern PE. VBN-based nomograms provide critical voiding parameters which can be used for invasive or non-invasive flow interpretation of women at risk of obstruction over time. Neurourol Urodyn. 2017;36:37–42. https://​doi.​org/​10.​1002/​nau.​22893 Application of “numerized nomogram”. CrossRefPubMed
Metadata
Title
Mathematical Modeling and Uroflow-Based Nomograms in Voiding Dysfunction Evaluation: Ready for Prime Time?
Authors
Françoise A. Valentini
Pierre P. Nelson
Publication date
01-06-2019
Publisher
Springer US
Published in
Current Bladder Dysfunction Reports / Issue 2/2019
Print ISSN: 1931-7212
Electronic ISSN: 1931-7220
DOI
https://doi.org/10.1007/s11884-019-00505-y

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