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Current Bladder Dysfunction Reports
Published in: Current Bladder Dysfunction Reports 4/2016

01-12-2016 | Neurogenic Bladder (C Powell, Section Editor)

Using the Native Afferent Nervous System to Sense Bladder Fullness: State of the Art

Authors: Lauren E. Tennyson, Changfeng Tai, Christopher J. Chermansky

Published in: Current Bladder Dysfunction Reports | Issue 4/2016

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Abstract

The regulation of micturition involves complex neurophysiologic pathways, and its understanding has grown immensely over the past decade. Alternative approaches and applied technologies in the treatment of bladder dysfunction have minimized the complications that result from neurogenic bladder. The use of natural bladder mechanoreceptors and electroneneurographic (ENG) signal recordings from afferent nerves to chronically monitor bladder volume is a promising concept, but the technology to accomplish this has proven to be a great biomedical engineering challenge. The focus of this paper will be to describe the current state of ENG signal recording as a method to detect bladder fullness.
Literature
1.••
Mendez A, Sawan M, Minagawa T, et al. Estimation of bladder volume from afferent neural activity. IEEE Trans Neural Syst Rehabil Eng. 2013;21(5):704–15. The authors record nerve activity from the Dorsal Root Ganglion taking advantage of the segregated nerve fibers, prove this is feasible, and accurately decode the signal to estimate bladder volume.CrossRefPubMed
2.
Mendez A, Sawan M. Chronic monitoring of bladder volume: a critical review and assessment of measurement methods. Can J Urol. 2011;18(1):5504–16.PubMed
3.
4.
5.
Habler HJ, Janig W, Koltzenburg M. Activation of unmyelinated afferent fibers by mechanical stimuli and inflammation of the urinary bladder in the cat. J Physiol. 1990;425:545–62.CrossRefPubMedPubMedCentral
6.
Yu Y, de Groat WC. Sensitization of the pelvic afferent nerves in the in vitro rat urinary bladder—pelvic nerve preparation by purinergic agonists and cyclophosphamide pretreatment. Am J Physiol Renal Physiol. 2008;294(5):F1146–56.CrossRefPubMedPubMedCentral
7.
Kurstjens G, Borau A, Rodriguez A, et al. Intraoperative recording of electroneurographic signals from cuff electrodes on extradural sacral roots in spinal cord injured patients. J Urol. 2005;174:1482–87.CrossRefPubMed
8.
Jezernik S, Grill WM, Sinkjaer T. Detection and inhibition of hyperreflexia-like bladder contractions in the cat by sacral nerve root recording and electrical stimulation. Neurourol Urodynam. 2001;20(2):215–30.CrossRef
9.
Ness TJ, Castroman P. Evidence for two populations of rat spinal dorsal horn neurons excited by urinary bladder distension. Brain Res. 2001;923(1-2):147–56.CrossRefPubMed
10.
Bruns TM, Gaunt RA, Weber DJ. Multielectrode array recordings of bladder and perineal primary afferent activity from the sacral dorsal root ganglia. J Neural Eng. 2011;8(5):056010.CrossRefPubMedPubMedCentral
11.
Sinkjaer T, Haugland M, Struijk J, et al. Long-term cuff electrode recordings from peripheral nerves in animals and humans. In: Windhorst U, Johansson H, editors. Modern techniques in neuroscience. New York, New York: Springer-Verlag; 1999. p. 787–802.
12.
Wozniak W, Skowronska U. Comparative anatomy of pelvic plexus in cat, dog, rabbit, macaque and man. Anat Anz. 1967;120(5):457–73.PubMed
13.••
Bruns TM, Gaunt RA, Weber DJ. Estimating bladder pressure from sacral dorsal root ganglia recordings. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:4239–42. The authors use a cat model to prove feasibility in measuring pressure using a complex microelectrode array placed in the S1 and S2 dorsal root ganglion. The authors’ detailed methods section should facilitate other investigators interested in reproducing their results.PubMedPubMedCentral
14.••
Bruns TM, Weber DJ, Gaunt RA. Microstimulation of afferents in the sacral dorsal root ganglia can evoke reflex bladder activity. Neurourol Urodyn. 2015;34(1):65–71. The authors leverage their experience and skill with cats to stimulate, not just listen, to the S1 and S2 dorsal root ganglion. They achieve bladder contraction by modulating the electrode stimulated and the frequency of stimulation. Similarly, by altering these parameters they demonstrated relaxation of the bladder in some, but not all, experimental animals.CrossRefPubMed
15.
Spinelli M, Sievert KD. Latest technologic and surgical developments in using InterStim Therapy for sacral neuromodulation: impact on treatment success and safety. Eur Urol. 2008;54(6):1287–96.CrossRefPubMed
16.
Melgaard J, Rijkhoff NJM. Detecting urinary bladder contractions: methods and devices. J Sens Technol. 2014;4:165–76.CrossRef
17.
Chapple CR, Osman NI, Birder L, et al. The underactive bladder: a new clinical concept? Eur Urol. 2015;68(3):351–3.CrossRefPubMed
18.
Mendez A, Belghith A, Sawan M. A DSP for sensing the bladder volume through afferent neural pathways. IEEE Trans Neural Syst Rehabil Eng. 2014;8(4):552–64.
Metadata
Title
Using the Native Afferent Nervous System to Sense Bladder Fullness: State of the Art
Authors
Lauren E. Tennyson
Changfeng Tai
Christopher J. Chermansky
Publication date
01-12-2016
Publisher
Springer US
Published in
Current Bladder Dysfunction Reports / Issue 4/2016
Print ISSN: 1931-7212
Electronic ISSN: 1931-7220
DOI
https://doi.org/10.1007/s11884-016-0391-2

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